Article
Biochemistry & Molecular Biology
Leah C. Ott, Christopher Y. Han, Jessica L. Mueller, Ahmed A. Rahman, Ryo Hotta, Allan M. Goldstein, Rhian Stavely
Summary: Neurons and glia of the peripheral nervous system are derived from progenitor cell populations originating from embryonic neural crest, and these cells have previously been shown to possess neural stem cell qualities. In this study, a population of neural crest-derived Schwann cells residing in the bone marrow, in association with nerve fibers, were found to exhibit plasticity and generate neural stem cells with neurogenic potential. These cells can form neural networks within the enteric nervous system following transplantation, making them a novel source of autologous neural stem cells for the treatment of neurointestinal disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Anna L. Hoeving, Beatrice A. Windmoeller, Cornelius Knabbe, Barbara Kaltschmidt, Christian Kaltschmidt, Johannes F. W. Greiner
Summary: The review highlights the cellular heterogeneity within neural crest-derived stem cell populations and emphasizes this heterogeneity as a crucial parameter for understanding their role in tissue homeostasis and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Giulia Bertani, Rosanna Di Tinco, Laura Bertoni, Giulia Orlandi, Alessandra Pisciotta, Roberto Rosa, Luca Rigamonti, Michele Signore, Jessika Bertacchini, Paola Sena, Sara De Biasi, Erica Villa, Gianluca Carnevale
Summary: The effects of pulsatile unidirectional flow and an inflammatory microenvironment on the biological properties of human dental pulp stem cells were evaluated in this study. The results showed that both pulsatile unidirectional flow and an inflammatory microenvironment led to a decrease in the immunomodulatory and inflammatory properties of dental pulp stem cells.
STEM CELL RESEARCH & THERAPY
(2023)
Retraction
Biochemistry & Molecular Biology
Sabine Wislet-Gendebien, Emerence Laudet, Virginie Neirinckx, Philippe Alix, Pierre Leprince, Aneta Glejzer, Christophe Poulet, Benoit Hennuy, Lukas Sommer, Olga Shakhova, Bernard Rogister
Summary: A correction to this paper has been published.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Hiba Asrar, Abigail S. Tucker
Summary: Major organs and tissues require close association with the vasculature during development and for later function. Recent research has revealed novel roles for endothelial cells in tissue morphogenesis and differentiation, highlighting the importance of providing a vasculature when constructing tissues and organs for tissue engineering. Important signaling pathways regulating the cross talk between endothelial cells and their environment have been identified in various organ systems.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cell & Tissue Engineering
Surangi N. Perera, Laura Kerosuo
Summary: The neural crest (NC) is a unique embryonic stem cell population in vertebrates, contributing to a wide range of derivatives. Recent discoveries have revealed the coexpression of pluripotency factors in NC cells, leading to the proposal of a new term pleistopotent. Studies on the maintenance of NC stemness are crucial for understanding its contribution to tissue formation.
Review
Cell Biology
Shun Yan, Jin Lu, Kai Jiao
Summary: Cardiac neural crest cells are a crucial cell population in heart development, and abnormalities in their development can lead to congenital heart defects. In addition to signaling molecules and transcription factors, epigenetic regulation also plays a significant role in the development of cardiac neural crest cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Polymer Science
Rosanna Di Tinco, Ugo Consolo, Alessandra Pisciotta, Giulia Orlandi, Giulia Bertani, Milena Nasi, Jessika Bertacchini, Gianluca Carnevale
Summary: This study evaluated the effects of three different bone substitute biomaterials (BSBs) on human dental pulp stem cells (hDPSCs). The results showed that the BSBs did not alter cell proliferation, stemness markers expression, or induce any inflammatory responses. Furthermore, the formulation of the BSBs also influenced the biological properties of the stem cells.
Review
Biochemistry & Molecular Biology
Lucio Diaz-Flores, Ricardo Gutierrez, Maria Pino Garcia, Miriam Gonzalez-Gomez, Lucio Diaz-Flores, Jose Luis Carrasco, Juan Francisco Madrid, Aixa Rodriguez Bello
Summary: Perivascular cells, including pericytes and CD34+ stromal cells/telocytes, play an important role in angiogenesis. The behavior and changes of these cells differ depending on the type of angiogenesis, involving various cell-to-cell interactions and signaling pathways. Perivascular cells and CD34+ stromal cells/telocytes have important functions in vessel development and tissue repair, while their involvement in intussusceptive angiogenesis is limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Oscar O. Solis-Castro, Marcelo N. Rivolta, Fiona M. Boissonade
Summary: Evidence suggests that dental-related stem cells (DRSCs) have the potential for ectodermal lineage differentiation and can be used in the treatment of neurodegenerative diseases and nerve injuries. However, there are limitations in current research, such as the reliance on detecting neural crest markers to classify DRSCs as NCSCs and the lack of studies proving their improved neuro-glial differentiation or applicability in relevant models. Furthermore, existing protocols need to meet manufacturing standards for clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bernhard Schick, Lukas Pillong, Gentiana Wenzel, Silke Wemmert
Summary: The etiology of juvenile angiofibroma has been controversial for a long time. In this study, immunohistochemical analyses and gene expression analysis were used to propose a new understanding of the disease, suggesting that it is a malformation derived from neural crest cells, which can explain its typical site of origin and blood supply characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Qunzhou Zhang, Phuong Nguyen, Justin C. Burrell, Jincheng Zeng, Shihong Shi, Rabie M. Shanti, Grace Kulischak, D. Kacy Cullen, Anh D. Le
Summary: This study identified a rapid biofabrication approach for functionalized NGCs by directing GMSCs conversion into GiSCs in 3D collagen hydrogel. The implantation of functionalized NGCs laden with GiSCs significantly improved functional recovery and axonal regeneration in a segmental facial nerve defect model in rats.
NPJ REGENERATIVE MEDICINE
(2021)
Article
Anatomy & Morphology
Camilla U. Niklasson, Elina Fredlund, Emanuela Monni, Jessica M. Lindvall, Zaal Kokaia, Emma U. Hammarlund, Marianne E. Bronner, Sofie Mohlin
Summary: HIF-2α plays a crucial role in normal trunk neural crest development, with dysregulation affecting important features such as stemness, migration, and development. Its expression levels must be strictly controlled to ensure proper neural crest cell functions.
DEVELOPMENTAL DYNAMICS
(2021)
Article
Cell Biology
Zhaocheng Zhang, Min Oh, Jun-Ichi Sasaki, Jacques E. Nor
Summary: The study shows that p53/p21 functions through Bmi-1 to prevent the vasculogenic differentiation of dental pulp stem cells.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Fawzia Bardag Gorce, Mais Al Dahan, Kavita Narwani, Jesus Terrazas, Monica Ferrini, Colonya C. Calhoun, Jettie Uyanne, Jun Royce-Flores, Eric Crum, Yutaka Niihara
Summary: This study reports on the isolation and expansion of neural crest stem cells (NCSCs) from the epithelium of oral mucosa (OM) using reagents that are GMP-certified and FDA-approved for clinical use. The findings suggest that NCSCs can be obtained from OM epithelium using clinical-grade reagents, which is of great significance for clinical applications in regenerative medicine.
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
