Article
Chemistry, Multidisciplinary
Ondrej Dyck, Andrew R. Lupini, Stephen Jesse
Summary: In this study, we demonstrate an electron beam direct-write process in an aberration-corrected scanning transmission electron microscope. This process differs from conventional electron-beam-induced deposition techniques as it uses a different mechanism and elemental tin (Sn) as a precursor to enable atom-by-atom direct writing. The atomic-sized electron beam is used to generate chemically reactive point defects in a graphene substrate, allowing the precursor atoms to migrate and bond to the defect sites for deposition.
Article
Engineering, Multidisciplinary
Ewelina Gacka, Piotr Kunicki, Andrzej Sikora, Robert Bogdanowicz, Mateusz Ficek, Teodor Gotszalk, Ivo W. Rangelow, Krzysztof Kwoka
Summary: This paper presents the fabrication process and electromechanical properties of novel atomic force microscopy probes using single-crystal boron-doped diamond. The developed probes show high durability and wear resistance, along with good linear current voltage response during testing.
Article
Chemistry, Multidisciplinary
Ondrej Dyck, Andrew R. Lupini, Stephen Jesse
Summary: The scanning transmission electron microscope is being developed into a platform for atomic-scale material manipulation and fabrication, offering new capabilities and applications. This approach may significantly impact research in microelectronics, quantum information science, and catalysis, by enabling precise control over atomic-scale structure and chemistry, and providing a better understanding of atomic-scale processes for larger-scale synthesis.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Ondrej Dyck, Andrew R. Lupini, Stephen Jesse
Summary: The engineering of quantum materials involves the development of tools for synthesis and characterization challenges. One key factor is atomic-scale modification for desired atomic structures. The use of scanning transmission electron microscopes (STEMs) allows for atomic-scale material manipulation but obstacles like in situ material delivery exist. This article presents progress on in situ thermal deposition platform for synthesis processes in a scanning transmission electron microscope.
Article
Anatomy & Morphology
Yu-Jing Zhang, Dong-Yu Chen, Xue-Ting Chao, Zi-Shu Dong, Zong-You Huang, Xia-Lin Zheng, Wen Lu
Summary: This study investigated the antennal sensilla of Copidosomopsis nacoleiae through scanning and transmission electron microscopy. Six types of sensilla were identified on the antennae, with different distribution patterns and potential functions discussed. Future research on host location mechanisms will build upon these observations.
MICROSCOPY RESEARCH AND TECHNIQUE
(2021)
Article
Microscopy
Marek Malac, Jesus Alejandro Marin Calzada, Mark Salomons, Darren Homeniuk, Patrick Price, Martin Cloutier, Misa Hayashida, Doug Vick, Sean Chen, Suliat Yakubu, Zhengxu (Darren) Wen, Marcus Leeson, Mohammad Kamal, Jason Pitters, John Kim, Xuanhao Wang, Olivier Adkin-Kaya, Ray Egerton
Summary: NanoMi is an open source electron microscopy platform that offers a modular and flexible design, suitable for various applications such as education and experimental development. It is capable of SEM, TEM, STEM, and ED imaging modes, with an expected resolution of around 10 nanometers.
Article
Nanoscience & Nanotechnology
Yongchen Liu, Wilder Acuna, Huairuo Zhang, Dai Q. Ho, Ruiqi Hu, Zhengtianye Wang, Anderson Janotti, Garnett Bryant, Albert V. Davydov, Joshua M. O. Zide, Stephanie Law
Summary: Terahertz technologies have broad applications and researchers are exploring the growth of Bi2Se3 on GaAs substrates as a step towards on-chip THz integrated systems. The study finds that achieving high-quality Bi2Se3 films requires an atomically smooth GaAs surface.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
William A. Hubbard, Jared J. Lodico, Ho Leung Chan, Matthew Mecklenburg, Brian C. Regan
Summary: The study reports the use of STEM EBIC imaging to directly visualize the electronic signatures of dielectric breakdown process in Pt/HfO2/Ti valence change memory devices. It is observed that DB proceeds through two distinct structures: a volatile, soft filament created by electron injection; and a non-volatile, hard filament created by oxygen-vacancy aggregation. This research makes a physical distinction between soft and hard DB, while also considering the progressive change in the relative lengths of the hard and soft filaments.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Environmental Sciences
Reshma Sinha, Rajinder Jindal
Summary: The study evaluated the effects of malachite green on the gills of Cyprinus carpio, revealing histopathological lesions and ultrastructural alterations at both cellular and tissue levels. The findings indicated damage to cellular nuclei and mitochondria, as well as impairment of antioxidative enzymes, ultimately leading to branchial toxicity in the fish.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kazuhiko Nakadate, Chiaki Sono, Homura Mita, Yuki Itakura, Kiyoharu Kawakami
Summary: Liver dysfunction is the main cause of hepatic encephalopathy, but the histopathological changes in the brain associated with hepatic encephalopathy remain unclear. In this study, a mouse model of acute hepatic encephalopathy was used to investigate the pathological changes in the liver and brain. The results indicated that hepatocyte swelling and cytoplasmic vacuolization progressed over time in the liver tissue, while histopathological changes such as perivascular astrocyte swelling and abnormalities in neuronal organelles were observed in the brain. Additionally, delayed neuronal atrophy and continued brain cytotoxicity were observed even after consciousness recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Yunzhe Zheng, Yuke Zhang, Tianjiao Xin, Yilin Xu, Shuangquan Qu, Junding Zheng, Zhaomeng Gao, Qilan Zhong, Yiwei Wang, Xiaoyu Feng, Yonghui Zheng, Yan Cheng, Ruiwen Shao, Fang Lin, Xiaoling Lin, He Tian, Rong Huang, Chungang Duan, Hangbing Lyu
Summary: This study used advanced electron microscopy techniques to investigate domain walls in Hf0.5Zr0.5O2 thin films. Different types of domain walls exhibited varying migration behaviors in response to the concentration of oxygen vacancies. Point defects and changes in the local strain field were found to drive domain wall switching in this material. These findings provide insights into the atomic-scale characteristics of domain walls and improve our understanding of the ferroelectric properties of Hf0.5Zr0.5O2 thin films.
MATERIALS TODAY NANO
(2023)
Article
Nanoscience & Nanotechnology
Thilini U. Dissanayake, Mei Wang, Taylor J. Woehl
Summary: This study utilized LP-TEM and FM techniques to investigate the crosslinking and chain scission reactions of polymeric nanoparticle ligands under electron beam irradiation, revealing their impact on ligand coverage and emphasizing the importance of controlling electron beam radiation chemistry to avoid disturbances.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
O. Dyck, M. Ziatdinov, S. Jesse, F. Bao, A. Yousefzadi Nobakht, A. Maksov, B. G. Sumpter, R. Archibald, K. J. H. Law, S. Kalinin
Summary: The structure, bonding, and chemical dynamics of reactions at surfaces and interfaces are closely tied to the energetic landscape where each atom resides. Moving atoms under electron beam excitation can be utilized to probe energy landscapes along confined step edges, offering insights into atomic-scale potentials and the possibility for predictive atom-by-atom fabrication.
Article
Chemistry, Multidisciplinary
Ondrej Dyck, Sinchul Yeom, Andrew R. Lupini, Jacob L. Swett, Dale Hensley, Mina Yoon, Stephen Jesse
Summary: Atomic-scale engineering combines bottom-up and top-down approaches to achieve atomic-scale precision patterning in twisted bilayer graphene, using an aberration-corrected scanning transmission electron microscope (STEM) and controlled ejection of carbon atoms. The application of global and local parameters allows for spontaneous arrangement of atoms and migration of adatoms on the material surface. Image-based feedback control facilitates the attachment of arbitrary patterns of atoms and atom clusters with limited human intervention. The role of substrate temperature in adatom and vacancy diffusion is studied through simulations.
ADVANCED MATERIALS
(2023)
Article
Multidisciplinary Sciences
Koji Inoue, Kenta Yoshida, Yasuyoshi Nagai, Kyosuke Kishida, Haruyuki Inui
Summary: APT and TEM/STEM were used correlatively to explore the atomic-scale local structure and chemistry changes during the growth of the LPSO phase in Mg-Al-Gd alloy. It was discovered that enrichment of Gd atoms precedes that of Al atoms, and the formation of Al6Gd8 clusters requires sufficient diffusion of Al atoms into the relevant portions. Lateral growth of the LPSO phase is believed to occur through a 'ledge' mechanism controlled by diffusion of Al atoms.
SCIENTIFIC REPORTS
(2021)
Review
Clinical Neurology
Rachel Kleinloog, Nikki de Mul, Bon H. Verweij, Jan Andries Post, Gabriel J. E. Rinkel, Ynte M. Ruigrok
Article
Chemistry, Multidisciplinary
Joel E. Schmidt, Linqing Peng, Alessandra Lucini Paioni, Helena Leona Ehren, Wei Guo, Baishakhi Mazumder, D. A. Matthijs de Winter, Ozgun Attila, Donglong Fu, Abhishek Dutta Chowdhury, Klaartje Houben, Marc Baldus, Jonathan D. Poplawsky, Bert M. Weckhuysen
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Chemistry, Physical
Fabian Hagemans, Ravi Kumar Pujala, Danisha S. Hotie, Dominique M. E. Thies-Weesie, D. A. Matthijs de Winter, Johannes D. Meeldijk, Alfons van Blaaderen, Arnout Imhof
CHEMISTRY OF MATERIALS
(2019)
Article
Neurosciences
Martin Harterink, Karin Vocking, Xingxiu Pan, Eva M. Soriano Jerez, Lotte Slenders, Amelie Freal, Roderick P. Tas, Willine J. van de Wetering, Karina Timmer, Jasmijn Motshagen, Sam F. B. van Beuningen, Lukas C. Kapitein, Willie J. C. Geerts, Jan A. Post, Casper C. Hoogenraad
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Amelie Freal, Dipti Rai, Roderick P. Tas, Xingxiu Pan, Eugene A. Katrukha, Dieudonnee van de Willige, Riccardo Stucchi, Amol Aher, Chao Yang, A. F. Maarten Altelaar, Karin Vocking, Jan Andries Post, Martin Harterink, Lukas C. Kapitein, Anna Akhmanova, Casper C. Hoogenraad
Article
Biochemical Research Methods
A. Schultze-Jena, M. A. Boon, D. A. M. de Winter, P. J. Th Bussmann, A. E. M. Janssen, A. van der Padt
JOURNAL OF CHROMATOGRAPHY A
(2020)
Article
Microscopy
M. F. Hayles, D. A. M. De Winter
Summary: The integration of cryo-techniques into FIB-SEM has allowed for the study of frozen, hydrated samples in Life Sciences. Cryo-TEM and cryo-SEM have provided valuable 2D information, while FIB-milling in cryo-FIB-SEM has added a third dimension for imaging purposes. This paper discusses the production of suitable cross-section results from Life Science samples using cryo-FIB-SEM.
JOURNAL OF MICROSCOPY
(2021)
Article
Microscopy
D. A. M. De Winter, C. Hsieh, M. Marko, M. F. Hayles
Summary: This paper discusses two methods for preparing cell samples for cryo-transmission electron microscope studies, emphasizing the importance of preserving the natural state of molecules and overcoming technical challenges posed by freezing conditions.
JOURNAL OF MICROSCOPY
(2021)
Article
Engineering, Chemical
K. Weishaupt, A. Terzis, I. Zarikos, G. Yang, B. Flemisch, D. A. M. de Winter, R. Helmig
TRANSPORT IN POROUS MEDIA
(2020)
Editorial Material
Microscopy
D. A. M. de Winter, C. D. J. Parmenter
JOURNAL OF MICROSCOPY
(2021)
Article
Engineering, Chemical
D. A. M. de Winter, K. Weishaupt, S. Scheller, S. Frey, A. Raoof, S. M. Hassanizadeh, R. Helmig
Summary: This study demonstrates the complexity of steady-state flow through porous media using CLSM, micro-PIV, and numerical modeling. The results highlight the non-trivial streamline trajectories and Brownian motion contributing to hydrodynamic mixing, as well as challenges in upscaling hydrodynamic dispersion from pore scale to REV scale. The quantitative validation of CLSM-based data provides a valuable benchmark for validating computer simulation results.
TRANSPORT IN POROUS MEDIA
(2021)
Article
Biophysics
Behdad Pouran, Amir Raoof, D. A. Matthijs de Winter, Vahid Arbabi, Ronald L. A. W. Bleys, Frederik J. Beekman, Amir. A. Zadpoor, Jos Malda, Harrie Weinans
Summary: Recent research has shown that the structure of nano-pores at the osteochondral interface significantly impacts the transport processes between cartilage and bone, with poor connectivity resulting in significantly reduced convection and diffusion. Studying the different-sized pores in calcified cartilage and subchondral bone plate revealed that the latter exhibits better connectivity and transport efficiency.
JOURNAL OF BIOMECHANICS
(2021)
Article
Biology
Ernest B. van der Wee, Jantina Fokkema, Chris L. Kennedy, Marc del Pozo, D. A. Matthijs de Winter, Peter N. A. Speets, Hans C. Gerritsen, Alfons van Blaaderen
Summary: This study introduces a single sample for calibrating STED and confocal microscopes, allowing calibration in three dimensions, alignment of laser beams, and measurement of PSF. The sample consists of refractive index matched colloidal crystal of specific structure, which can be used for improving the quality of microscopic images.
COMMUNICATIONS BIOLOGY
(2021)
Article
Engineering, Chemical
Alraune Zech, Matthijs de Winter
Summary: In this study, diffusive transport parameters were investigated using a stochastic framework, showing significant scatter at sub-REV scale due to complexity of pore space geometry. By mathematically characterizing scatter through a probability distribution function, it was found that while porosity observations decreased linearly with sample size, transport-ability did not converge to zero. The impact of pore structure differences on transport parameters at all scales was confirmed, advocating the use of PDFs for effective parameters in both continuum equations and data interpretation.
TRANSPORT IN POROUS MEDIA
(2023)
Article
Chemistry, Multidisciplinary
Jessi E. S. van der Hoeven, Ernest B. van der Wee, D. A. Matthijs de Winter, Michiel Hermes, Yang Liu, Jantina Fokkema, Maarten Bransen, Marijn A. van Huis, Hans C. Gerritsen, Petra E. de Jongh, Alfons van Blaaderen