Review
Endocrinology & Metabolism
Ekua W. Brenu, Mark Harris, Emma E. Hamilton-Williams
Summary: This systematic review evaluates novel circulating biomarkers associated with future progression to type 1 diabetes (T1D). The study found that some circulating biomarkers are dysregulated before T1D diagnosis and may be useful in predicting the risk and rate of progression to T1D. However, further research is needed to validate these biomarkers and assess their predictive accuracy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Michelle J. Gould, Farid H. Mahmud, Antoine B. M. Clarke, Charlotte McDonald, Fred Saibil, Zubin Punthakee, Margaret A. Marcon
Summary: This study evaluated the diagnostic performance of celiac serologic tests in asymptomatic patients with type 1 diabetes, finding that thresholds extrapolated from the general population are not suitable for use in this specific population, emphasizing the need for population-specific screening cutoffs.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Health Care Sciences & Services
Claudia Eberle, Stefanie Stichling
Summary: Telemedical interventions may effectively improve diabetes control and significantly reduce HbA(1c) concentrations. The benefits of telemedicine could be greater for patients with T2DM compared to those with T1DM.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Review
Endocrinology & Metabolism
Rebecca Unsworth, Parizad Avari, Aaron M. Lett, Nick Oliver, Monika Reddy
Summary: This systematic review examined studies on adaptive insulin bolus calculators for people with type 1 diabetes. The limited clinical trials available suggest the potential for personalized and adaptive management of type 1 diabetes, but further research is needed to fully support its efficacy and implementation.
DIABETES OBESITY & METABOLISM
(2023)
Review
Pediatrics
Xue Zhang, Xiang-fei Xu, Jie Jin
Summary: This study found that there is no association between rotavirus vaccination and the risk of type 1 diabetes or celiac disease in children. The protective effect of rotavirus vaccination on type 1 diabetes may be dependent on the age of vaccination.
FRONTIERS IN PEDIATRICS
(2022)
Review
Public, Environmental & Occupational Health
Cuiping Lin, Xuan Li, Yu Qiu, Zheng Chen, Jianping Liu
Summary: PD-1 inhibitor-associated type 1 diabetes progresses rapidly, leading to islet failure and endangering patients' lives. Patients receiving PD-1 inhibitors should closely monitor their blood glucose levels.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Xiaofan Jia, Ling He, Dongmei Miao, Caiguo Zhang, Marian Rewers, Liping Yu
Summary: The ongoing clinical trial, Autoimmunity Screening for Kids (ASK), is the first study in the general population in the United States to screen for type 1 diabetes (T1D) and celiac disease. In response to the COVID-19 pandemic, there is an urgent need to understand the epidemiology of COVID-19 in the general population and its association with T1D development. A novel 6-Plex electrochemiluminescence (ECL) assay has been developed and validated as the primary screening tool for the ASK study, offering high efficiency, low cost, and low serum volume for the detection of T1D, celiac disease, and COVID-19.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Review
Biochemistry & Molecular Biology
Josephine Yu, Preeti Sharma, Christian M. Girgis, Jenny E. Gunton
Summary: The prevalence of type 1 diabetes is rising steadily and vitamin D may contribute to this increase. This systematic review examined studies on vitamin D and type 1 diabetes, finding strong associations between low vitamin D levels and type 1 diabetes. Animal studies and human trials also suggest that vitamin D treatment or supplementation can be beneficial in reducing the risk of type 1 diabetes. Maintaining optimal circulating 25-hydroxyvitamin D levels may help to prevent or delay the development of type 1 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Hanna Soederstrom, Julia Rehn, Matti Cervin, Cathrine Ahlstermark, Mara Cerqueiro Bybrant, Annelie Carlsson
Summary: Children with both type 1 diabetes (T1D) and celiac disease (CD) have lower compliance to a gluten-free diet compared to children with CD only. Results suggest that intensified dietary support may be necessary for children with both T1D and CD, particularly for older children and those with poor metabolic control.
Review
Endocrinology & Metabolism
Ioannis Avgerinos, Thomas Karagiannis, Panagiota Kakotrichi, Theodoros Michailidis, Aris Liakos, David R. Matthews, Apostolos Tsapas, Eleni Bekiari
Summary: Sotagliflozin demonstrates efficacy in reducing blood glucose, body weight, and systolic blood pressure in patients with type 2 diabetes, with beneficial effects on heart failure and myocardial infarction. Its overall safety profile is comparable with other sodium-glucose cotransporter-2 inhibitors.
DIABETES OBESITY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Jumana Abuqwider, Alessandra Corrado, Giuseppe Scida, Roberta Lupoli, Giuseppina Costabile, Gianluigi Mauriello, Lutgarda Bozzetto
Summary: There is a distinct difference in gut microbiome between patients with type 1 diabetes and healthy individuals, which may lead to changes in gut permeability, inflammation, and poor glucose management.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Emilia Majsiak, Magdalena Choina, Izabela Knyziak-Medrzycka, Joanna Beata Bierla, Kamil Janeczek, Julia Wykrota, Bozena Cukrowska
Summary: A systematic review of published studies suggests that individuals with celiac disease may also have IgE-mediated allergies. It is important to consider screening for allergies, especially in cases where symptoms persist after a gluten-free diet. Wheat sensitization is the most common allergy in celiac disease patients, and the clinical manifestations are similar to those without celiac disease.
Review
Immunology
Shuo Zhang, Feiying Deng, Jingxian Chen, Fengwu Chen, Zezhen Wu, Liping Li, Kaijian Hou
Summary: There is a strong relationship between fecal microbiota and the development of type 1 diabetes. Fecal microbiota transplantation has emerged as a safe and effective therapy for various intestinal and extraintestinal diseases. It has been found that fecal microbiota transplantation can correct immune disorders, leading to improved disease outcomes. Additionally, it has been shown to improve glycemic control and insulin resistance in diabetic patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Bruce A. Perkins, Ionut Bebu, Ian H. de Boer, Mark Molitch, Bernard Zinman, John Bantle, Gayle M. Lorenzi, David M. Nathan, John M. Lachin
Summary: This study aimed to determine a simple screening schedule based on risk factors that optimizes early detection and testing frequency. The results showed that personalized screening can significantly reduce the time with undetected kidney disease and the frequency of urine testing, improving treatment outcomes.
Article
Medicine, General & Internal
Chloe Girard, Aurelie De Percin, Carole Morin, Maeva Talvard, Francoise Fortenfant, Nicolas Congy-Jolivet, Claire Le Tallec, Jean-Pierre Olives, Emmanuel Mas
Summary: The purpose of this study was to determine the prevalence of celiac disease (CD) in children with type 1 diabetes (T1D) using the latest guidelines and avoiding intestinal biopsies. The study found a 4.8% prevalence of CD in 663 T1D children, with 95% of them expressing HLA-DQ2 and/or -DQ8 genes. Screening for CD is recommended for all patients, and regular TGA assessment is necessary for T1D patients who are genetically predisposed.
MEDICINA-LITHUANIA
(2023)
Article
Nutrition & Dietetics
Megan L. Gow, Yei W. Lam, Hiba Jebeile, Maria E. Craig, Daniella Susic, Amanda Henry
Summary: The study found a significant association between depression scores during pregnancy and postpartum depression, emphasizing the importance of screening for depression during pregnancy and postnatally. After adjusting for various factors, the correlation between diet quality during the third trimester of pregnancy and depression was only observed during the same trimester.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2023)
Article
Pediatrics
Joel Vanderniet, Kristen A. Neville, Louise S. Conwell, Eva A. Wegner, Maria E. Craig, Susan Adams, Andrew J. Gifford, Melissa Koutsiofi, Frances M. Calabria, Gemma Maguire, Paul Thomas, Louise Campbell, Helen J. Woodhead
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Article
Endocrinology & Metabolism
Diana M. M. Bond, Radhika Seimon, Francisco J. J. Schneuer, Louise A. A. Baur, Maria Craig, Shirley Alexander, Sarah P. P. Garnett, Joanne Henderson, Natasha Nassar
Summary: Recent evidence suggests that the immediate effects of COVID-19 lockdowns and restrictions have led to increased weight in children and adolescents. However, the longer-term effects have not been assessed. This study examines the impact and longer-term effects of the pandemic on BMI and weight status in children and adolescents using clinical data from two children's hospitals in Australia from 2018 to 2021. The study found an initial increase in BMI and overweight/obesity rates, but these returned to pre-pandemic levels over time, possibly due to state-wide policies targeting childhood obesity.
Article
Medicine, General & Internal
Helena C. Oakey, Lynne L. Giles, Rebecca Thomson, Kim-Anh Le Cao, Pat D. Ashwood, James J. Brown, Emma C. Knight, Simon E. Barry, Maria G. Craig, Peter A. Colman, Elizabeth E. Davis, Emma C. Hamilton-Williams, Leonard Harrison, Aveni Haynes, Ki Wook Kim, Kylie-Ann Mallitt, Kelly McGorm, Grant D. Morahan, William O. Rawlinson, Richard Sinnott, Georgia M. Soldatos, John J. Wentworth, Jennifer Couper, Megan A. S. Penno, ENDIA Study Grp
Summary: The ENDIA nested case-control study will utilize longitudinal omics data to explore the developmental origins of type 1 diabetes (T1D) in 190 children at risk, including 54 who have developed islet autoimmunity (IA), by collecting data during pregnancy, at birth, and in early childhood.
ANNALS OF MEDICINE
(2023)
Review
Virology
Roy Wu, Mohsin Mumtaz, Anna J. J. Maxwell, Sonia R. R. Isaacs, Jutta E. E. Laiho, William D. D. Rawlinson, Heikki Hyoty, Maria E. E. Craig, Ki Wook Kim
Summary: Among environmental factors associated with T1D, enterovirus infections have been identified as the main trigger for T1D development. However, the association between respiratory tract infections and T1D is not well understood. There is a lack of molecular-level data characterizing infectious agents, preventing the identification of specific agents driving the association between respiratory infections and T1D. The impact of SARS-CoV-2 infections on IA/T1D development remains unclear.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Endocrinology & Metabolism
Leonard C. Harrison, Esther Bandala-Sanchez, Helena Oakey, Peter G. Colman, Kelly Watson, Ki Wook Kim, Roy Wu, Emma E. Hamilton-Williams, Natalie L. Stone, Aveni Haynes, Rebecca L. Thomson, Peter J. Vuillermin, Georgia Soldatos, William D. Rawlinson, Kelly J. McGorm, Grant Morahan, Simon C. Barry, Richard O. Sinnott, John M. Wentworth, Jennifer J. Couper, Megan A. S. Penno, ENDIA Study Grp
Summary: A study found that the production of pancreatic islet autoantibodies in children with genetic susceptibility may be related to enteric virus infection, indicating that enteric infection could be one of the environmental factors driving the development of autoimmune diseases.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Pediatrics
Kelly D. McGorm, James G. Brown, Alison Roberts, Susan Greenbank, Daniella Brasacchio, Alyssa C. P. Sawyer, Helena G. Oakey, Peter E. Colman, Maria A. Craig, Elizabeth Davis, Georgia L. Soldatos, Rebecca M. Thomson, John J. Wentworth, Jennifer Couper, Megan A. S. Penno
Summary: This study examined the research experiences of caregivers and their children in the ENDIA study. The results showed that 95% of caregivers rated the research experience as excellent or good, and 81% of children expressed satisfaction. Caregivers were motivated by contributing to research and monitoring their children for T1D. The children's preferences were different from their caregivers', with a dislike for blood tests being the main reason for potential withdrawal.
Article
Endocrinology & Metabolism
S. James, K. C. Donaghue, L. Perry, J. Lowe, P. G. Colman, M. E. Craig
Summary: The aim of this study was to determine the frequency and levels of low-density lipoprotein cholesterol (LDL-C) screening, as well as factors associated with elevated LDL-C, in Australasian youth with type 1 diabetes (T1D). The study found that 25.3% of the young T1D patients had elevated LDL-C and 46.0% had LDL-C levels exceeding the normal range. The findings suggest the need for measures to strengthen LDL-C screening and management in this population to reduce the risk of cardiovascular complications.
Article
Endocrinology & Metabolism
Dunya Tomic, Maria E. Craig, Dianna J. Magliano, Jonathan E. Shaw
Summary: Youth with type 1 diabetes in Australia have a higher risk of hospitalization compared to the general population, especially for infections and mental health disorders. Ketoacidosis is a major reason for hospital admissions, with about 15% occurring within 3 months of diabetes diagnosis. Residence in areas of high socio-economic disadvantage is an independent risk factor for ketoacidosis admissions and readmissions.
Article
Endocrinology & Metabolism
Angela Titmuss, Federica Barzi, Elizabeth L. M. Barr, Vanya Webster, Anna Wood, Joanna Kelaart, Marie Kirkwood, Christine Connors, Jacqueline A. Boyle, Elizabeth Moore, Jeremy Oats, H. David McIntyre, Paul Zimmet, Alex D. H. Brown, Jonathan E. Shaw, Maria E. Craig, Louise J. Maple-Brown
Summary: This study found that maternal gestational diabetes mellitus (GDM) and type 2 diabetes (T2D) can influence childhood anthropometry, and maternal body mass index (BMI) plays a role in these associations.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Pediatrics
Megan L. Gow, Priya Vakil, Lynne Roberts, Greg Davis, Joseph M. Khouri, Ana Dosen, Mark A. Brown, Maria E. Craig, Amanda Henry
Summary: This study compared growth outcomes of infants exposed to different types of hypertensive pregnancies from birth to 2 years. It found that infants exposed to preeclampsia had lower birth weight and length, but there were no differences in growth outcomes at 6 months or 2 years. Infants exposed to gestational hypertension and preeclampsia experienced greater weight gain and rapid weight gain from birth to 2 years.
PEDIATRIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
Steven James, Lin Perry, Julia Lowe, Kim Donaghue, Anna Pham-Short, Maria Craig
Summary: This study compares adolescents and young adults with type 1 diabetes (T1D), with or without celiac disease (CD), and examines the impact on HbA1c and clinical outcomes. The results show that individuals with both T1D and CD have lower HbA1c levels compared to those with only T1D, but HbA1c levels are above target in both groups.
ACTA DIABETOLOGICA
(2023)
Meeting Abstract
Nutrition & Dietetics
R. L. Thomson, J. D. Brown, H. Oakey, M. A. S. Penno, R. Battersby, P. Ashwood, G. Soldatos, P. G. Colman, M. E. Craig, E. A. Davis, M. Harris., L. C. Harrison, A. Haynes, C. Morbey, R. O. Sinnott, P. J. Vuillermin, J. M. Wentworth, J. J. Couper
PROCEEDINGS OF THE NUTRITION SOCIETY
(2023)