Article
Polymer Science
Slawomir Blasiak, Pawel Andrzej Laski, Jakub Emanuel Takosoglu
Summary: The study aimed to design and produce a pneumatic directional control valve for controlling pneumatic drives, focusing on determining flow parameters and optimizing flow to achieve high performance and efficiency.
Article
Nanoscience & Nanotechnology
Futianchun Zhu, Yu He, Zefan Lu, Hongliang Fan, Tao Zhang
Summary: This paper introduces a novel concept of composite elastomers to provide flexible support for photocured thin films, allowing most photocurable resins to be used in microfluidic device fabrication. The rapid and simple fabrication process is expected to bridge the gap between academic research and industrial practice, greatly enriching material choices for diverse applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Juliane Diehm, Verena Hackert, Matthias Franzreb
Summary: This paper presents a method for manufacturing valves for microfluidic chips using 3D printing technology, and compares different printing techniques and sealing structures. After evaluation, it is found that the performance of these 3D printed valves is similar to traditional commercial valves or other 3D printed valves, with leakage below 0.5% in both static and dynamic conditions.
Article
Chemistry, Multidisciplinary
Shanshan Qin, Gaozhi Ou, Biao Wang, Zheyu Li, Rui Hu, Ying Li, Yunhuang Yang
Summary: This study reports a photolithography-free method for rapid fabrication of PDMS devices. By using a laser cutter to ablate a tape, a male photoresist mold can be obtained within 5 minutes by a simple heating-step. The method offers advantages of low input, simple operation procedure, and short fabrication time.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Analytical
Roberto Paoli, Davide Di Giuseppe, Maider Badiola-Mateos, Eugenio Martinelli, Maria Jose Lopez-Martinez, Josep Samitier
Summary: This paper discusses the application of digital manufacturing and rapid prototyping technologies in Organ-on-a-Chip applications, as well as the main thermoplastic material choices and manufacturing methods, and investigates the limitations of the PDMS soft lithography strategy.
Article
Materials Science, Multidisciplinary
Santiago Franco Corredor, Fadoua Mayoussi, Manuel Luitz, Andrea Kick, Andreas Goralczyk, David Boecherer, Grace Vera, Dorothea Helmer, Frederik Kotz-Helmer, Bastian E. Rapp
Summary: Polystyrene (PS) is a commonly used material in medical, biological, and biomedical applications due to its beneficial properties. However, rapid prototyping and high-resolution shaping of PS, particularly on a micron scale, are still limited. This study introduces a novel photocurable PS photoresin that enables the fabrication of microfluidic chips with high optical transparency and comparable properties to commercial PS. This method allows researchers in various fields to produce suitable PS structures using commercial equipment.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Biochemical Research Methods
Xianming Qin, Xueyong Wei, Lei Li, Hairong Wang, Zhuangde Jiang, Dong Sun
Summary: The novel concept of acoustic valves in microfluidic channels uses focused acoustic fields to control droplets, eliminating the need for high voltage or sample modification. This non-contact manipulation method is suitable for biochemical experiments with minimal requirements, especially those involving optical observation and chemical reactions.
Article
Nanoscience & Nanotechnology
Sebastian Bohm, Hai Binh Phi, Ayaka Moriyama, Erich Runge, Steffen Strehle, Jorg Konig, Christian Cierpka, Lars Dittrich
Summary: A multistage optimization method is developed to create efficient Tesla valves at low flow rates. The method uses topological optimization based on the finite element method, resulting in compact valve structures that can be directly used in microfluidic systems.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Biochemical Research Methods
Chao Li, Sue McCrone, Jay W. Warrick, David R. Andes, Zachary Hite, Cecilia F. Volk, Warren E. Rose, David J. Beebe
Summary: Antimicrobial susceptibility testing (AST) is crucial for effective antimicrobial selection and optimization in patients. Microfluidics-based phenotypic AST, such as the under-oil open microfluidic systems (UOMS) described in this pilot study, offers a rapid and accurate approach for testing antimicrobial activities. UOMS-AST provides open access and optical resolution, and can determine susceptibility/resistance breakpoint and minimum inhibitory concentration (MIC) quickly. By combining UOMS-AST with cloud lab data analytics, a fast sample-to-report turnaround time of less than 4 hours can be achieved, making it a versatile platform for phenotypic AST in hospital/clinic settings.
Article
Chemistry, Analytical
Angela Ecija-Arenas, Antonio Zafra-Poyato, Juan Manuel Fernandez-Romero
Summary: A stopped-flow microfluidic fluorimetric biosensor has been developed to monitor alkaline phosphatase (ALP) activity and evaluate potential inhibitors. The biosensor integrates a magnetically retained enzyme microreactor (MRE mu R) in the reaction/detection zone of a microfluidic chip. The analytical signal is based on the fluorescence decrease observed in the dephosphorylation reaction of the substrate caused by sulfonamides. Evaluation of the method showed promising results with high recovery values.
Article
Chemistry, Multidisciplinary
Robin Dinter, Suzanne Willems, Thilo Nissalk, Oguz Hastuerk, Andreas Brunschweiger, Norbert Kockmann
Summary: The transfer from batch to flow chemistry often involves commercial microfluidic equipment, which is not easily customizable for technologies like DELT. Customized photoreactor concepts using rapid prototyping technology provide a modular, flexible, and affordable design. A photochemical pinacol coupling reaction was conducted to validate the prototype reactors, with optimized conversion rates by adapting the microfluidic flow photoreactor module's design parameters. By switching to LEDs with a wavelength of 454 nm, the photoreactor module was extended to an application with DNA-tagged substrates. The successful recovery of DNA confirmed the feasibility of the modular-designed flow photoreactor. This collaborative approach holds enormous potential for driving the development of DELT and flow equipment design.
FRONTIERS IN CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Adam L. Bachmann, Brendan Hanrahan, Michael D. Dickey, Nathan Lazarus
Summary: This paper presents a method of laser forming that can self-fold 2D printed circuit boards into 3D structures with electronic function. The laser settings are tuned to achieve cutting or folding, and two approaches are explored to enable folding of commercial PCBs. The technique can create complex, multifold structures with integrated electronics, and has the potential for rapid prototyping of complex 3D electronics.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Alper Baran Sozmen, Ahu Arslan Yildiz
Summary: A new polymer-assisted bonding method was proposed, combined with various phase-changing materials as channel-protective agents. Through experimentation, the optimal bonding solvent and polymer concentration were determined and successfully applied in the fabrication of a micro-droplet generator.
MICROFLUIDICS AND NANOFLUIDICS
(2021)
Article
Chemistry, Analytical
Arpith Vedhanayagam, Michael Golfetto, Jeffrey L. Ram, Amar S. Basu
Summary: This paper presents a method for fabricating sub-100 μm microfluidic channels using a low-cost 3D resin printer. The method allows for the production of microchannels with a lateral resolution of 44 μm, and has a fast turnaround time of one day. This low-cost method is attractive for many microfluidic labs due to its high resolution and affordability.
Article
Nanoscience & Nanotechnology
Christian Griesche, Kilian Hoecherl, Antje J. Baeumner
Summary: Laser-induced graphene (LIG) is a desirable electrode material for bio- and chemosensors due to its graphene-like characteristics. The study found that the direct pressure-driven transfer of LIG electrodes onto standard polymer substrates produces highly functional transfer-LIG (tLIG) electrodes which outperformed LIG electrodes in some aspects, especially in more advanced microfluidic channel systems. LIG and tLIG have the potential to change electroanalytical sensing in diagnostic systems with their scalable and easy-to-integrate fabrication process.
ACS APPLIED NANO MATERIALS
(2021)
Article
Engineering, Biomedical
Holly S. Lay, Gerard Cummins, Benjami F. Cox, Yongqiang Qiu, Mihnea Vlad Turcanu, Rachael McPhillips, Ciaran Connor, Rachael Gregson, Eddie Clutton, Marc P. Y. Desmulliez, Sandy Cochran
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2019)
Article
Engineering, Manufacturing
Raphael Adamietz, Marc P. Y. Desmulliez, Sumanth Kumar Pavuluri, Tim Tilford, Chris Bailey, Thomas Schreier-Alt, Jens Warmuth
IEEE TRANSACTIONS ON COMPONENTS PACKAGING AND MANUFACTURING TECHNOLOGY
(2019)
Article
Engineering, Electrical & Electronic
Assel Ryspayeva, Thomas D. A. Jones, Mohammadreza Nekouie Esfahani, Matthew P. Shuttleworth, Russell A. Harris, Robert W. Kay, Marc P. Y. Desmulliez, Jose Marques-Hueso
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2019)
Article
Engineering, Electrical & Electronic
Sadeque Reza Khan, Sumanth Kumar Pavuluri, Gerard Cummins, Marc P. Y. Desmulliez
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
(2019)
Article
Robotics
Joseph C. Norton, Piotr R. Slawinski, Holly S. Lay, James W. Martin, Benjamin F. Cox, Gerard Cummins, Marc P. Y. Desmulliez, Richard E. Clutton, Keith L. Obstein, Sandy Cochran, Pietro Valdastri
Article
Chemistry, Analytical
Sadeque Reza Khan, Marc P. Y. Desmulliez
Review
Chemistry, Analytical
Sadeque Reza Khan, Sumanth Kumar Pavuluri, Gerard Cummins, Marc P. Y. Desmulliez
Article
Engineering, Manufacturing
Reza N. Esfahani, Matthew P. Shuttleworth, Viktor Doychinov, Nathan J. Wilkinson, Jack Hinton, Tom D. A. Jones, Assel Ryspayeva, Ian D. Robertson, Jose Marques-Hueso, Marc. P. Y. Desmulliez, Russell A. Harris, Robert W. Kay
ADDITIVE MANUFACTURING
(2020)
Review
Chemistry, Analytical
Gergely Hantos, David Flynn, Marc P. Y. Desmulliez
Summary: A novel taxonomy of built-in self-test (BIST) methods for testing micro-electro-mechanical systems (MEMS) is presented in this study. With MEMS testing accounting for 50% of total costs, cost-effective and non-intrusive BIST solutions are actively sought after. A classification table benchmarks different testing methods based on ease of implementation, usefulness, test duration, and power consumption, providing insights into their domain of application.
Article
Engineering, Manufacturing
Gergely Hantos, Marc P. Y. Desmulliez
Summary: This article investigates the root causes of failures affecting the low-frequency response of MEMS microphones and proposes methods to induce these failures. The information obtained from the frequency response of the devices is insufficient to separate the root causes of failures, but additional information about the circumstances regarding the onset of defects is sufficient for root cause identification.
IEEE TRANSACTIONS ON SEMICONDUCTOR MANUFACTURING
(2021)
Article
Engineering, Manufacturing
Gergely Hantos, Gergely Simon, Marc P. Y. Desmulliez
Summary: This article presents a framework for detecting failures in mobile phone microphones, using frequency response analysis and acoustic measurements with new techniques. It demonstrates a high success rate for non-invasive fault detection.
IEEE TRANSACTIONS ON COMPONENTS PACKAGING AND MANUFACTURING TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Assel Ryspayeva, Adilet Zhakeyev, Marc P. Y. Desmulliez, Jose Marques-Hueso
Summary: The article presents a 3D printing technique that enables the manufacturing of selectively plated polymer objects using photopolymer printing and copper metallization. The method eliminates the sensitization step and involves the inclusion of silver seeds in the printing process to enable direct electroless copper metallization.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Engineering, Multidisciplinary
Falk Tauber, Marc Desmulliez, Olivier Piccin, Adam A. Stokes
Summary: Since the 1960s, soft robotics has been steadily growing, and recent innovations in rapid prototyping and flexible materials have enabled the development of fully flexible and untethered soft robotic systems. The integration of novel sensors and manufacturing processes shows promise for the future of soft robotics, with a focus on manufacturing techniques and tactile sensors for better interaction with the environment. The article highlights the potential of embodied intelligence in soft robots for autonomous computation from sensory inputs.
BIOINSPIRATION & BIOMIMETICS
(2023)
Article
Computer Science, Information Systems
Sadeque Reza Khan, Srinjoy Mitra, Marc P. Y. Desmulliez
Summary: Capsule endoscopy is considered a technological breakthrough in the diagnosis and treatment of gastrointestinal pathologies. Accurately determining the capsule's location is crucial for surgical intervention or drug delivery, necessitating further research to improve localization techniques. The dual use of wireless power transfer as a method for determining capsule location shows promising results with a maximum error of 12%.
Article
Biochemical Research Methods
Gergely Simon, Caroline Busch, Marco A. B. Andrade, Julien Reboud, Jonathan M. Cooper, Marc P. Y. Desmulliez, Mathis O. Riehle, Anne L. Bernassau
Summary: This paper introduces an acoustic bandpass method that overcomes traditional limitations, utilizing a single transducer pair for stable continuous flow sorting of blood cells. The method demonstrates high purity and efficiency coefficients when sorting particles of various sizes, and is further validated for separating red blood cells, white blood cells, and smaller particles.