Article
Engineering, Electrical & Electronic
Md. Junayed, Wei Ru Wong
Summary: The phenomenon of asymmetric Fano resonance supported by plasmonic nanohole arrays has attracted significant interest in ultrasensitive label-free biosensing. This study proposes a unique plasmonic octamer nanohole array structure with multiple asymmetric spectral resonances, offering excellent transmission efficiency and nanometer-level linewidth. The proposed structure exhibits high sensitivity for the analyte layer refractive index and shows promise for detecting immobilized DNA monolayers.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Analytical
Kang Yang, Meiying Li
Summary: In this study, it is theoretically investigated that the sensitivity of a hexagonal Au nanohole array sensor can be improved by 80% and 150% for bulk sensitivity and surface sensitivity, respectively, by simply increasing the incident angle from 0° to 40°. This finding is of great significance for enhancing and applying the performance of surface plasmon resonance sensors.
Article
Engineering, Electrical & Electronic
Zhiyong Yin, Xili Jing, Ge Bai, Biao Wu, Zhigang Gao, Chaoyi Liu, Chun Wang, Yuxin Li
Summary: To meet the requirement for sensor miniaturization and integration, a compact dual-parameter surface plasmon resonance (SPR) fiber sensor has been proposed for simultaneous measurement of liquid refractive index (RI) and temperature. The sensor consists of input-output couplers and two sensing arms, using no core fibers (NCFs) and microstructured optical fiber (MOF) with deposited films. Numerical simulations show that the cladding mode is more advantageous for stimulating the SPR effect. Experimental results demonstrate high sensitivities for liquid RI (4139 nm/RIU in the range of 1.333-1.365) and liquid temperature (4.7 nm/degrees C in the range of 20 degrees C-70 degrees C). The compact structure of this sensor offers promising applications in RI and temperature monitoring.
IEEE SENSORS JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Beyza Nur Gunaydin, Mert Gulmez, Milad Torabfam, Zeki Semih Pehlivan, Atacan Tutuncuoglu, Cemre Irmak Kayalan, Erhan Saatcioglu, Mustafa Kemal Bayazit, Meral Yuce, Hasan Kurt
Summary: In this study, plasmonic TiN thin films were successfully deposited using reactive RF magnetron sputtering. By optimizing the operation procedures and material structure, the plasmonic performance of the films was improved. The performance of the TiN thin films was evaluated using periodic nanohole arrays, highlighting their potential for refractometric sensing.
ACS APPLIED NANO MATERIALS
(2023)
Article
Automation & Control Systems
Chun Liu, Jinglan Zhang, Yiping Zhao, Bin Ai
Summary: In this study, deep learning is utilized to predict the structural parameters of Ag nanohole arrays for spectrum-driving and color-driving plasmonic applications. A bidirectional neural network is trained on a dataset of transmission spectra and structural parameters of NAs, resulting in high accuracy for predicting the structural parameters using a desired spectrum. The proposed strategy enables efficient design of nanostructures for various plasmonic applications and allows for nanoscale printing at high resolution.
ADVANCED INTELLIGENT SYSTEMS
(2023)
Article
Chemistry, Analytical
Chengcheng Wang, Tao Wu, Xiangmin Miao, Po Wang, Qiumei Feng
Summary: In this study, a dual-stimuli responsive electrochemiluminescence (ECL) sensor was developed for the detection and sterilization of Staphylococcus aureus (S. aureus). The sensor utilized silver nanoclusters labeled hairpin DNA (H-Ag NCs) as the energy acceptor of ECL emission from CdS quantum dots (CdS QDs), generating resonance energy transfer (RET) and quenching ECL signal. The proposed method showed excellent performance in the detection of S. aureus in foods, with a linear range of 5-108 CFU/mL.
Article
Chemistry, Physical
Zhenshi Chen, Xincheng Huang, Hui Zhang
Summary: A high performance surface plasmon resonance (SPR) fiber sensor based on metallic elliptical nanohole and circular nanodisk binary array is designed and investigated in this work. The binary array structure integrated on the end facet of optical fiber can generate three optical resonance dips in the near-infrared region. The first dip shows narrow linewidth, high peak-to-dip signal ratio, and sensitivity. The sensor exhibits high refractive index (RI) sensitivity, narrow FWHM, and high FOM value simultaneously. The composite plasmonic structure of nanodisk and elliptical nanohole array can generate SPR modes with sharper spectral feature, which is crucial for high sensitivity and precision detection technology.
Article
Multidisciplinary Sciences
Donato Conteduca, Isabel Barth, Giampaolo Pitruzzello, Christopher P. Reardon, Emiliano R. Martins, Thomas F. Krauss
Summary: Dielectric metasurfaces have different Q-factor and light localisation requirements for sensing and imaging. Here, the authors present a dielectric metasurface, supporting two optical modes with sharp Fano resonances for high Q-factors and strong spatial confinement, allowing both sensing and imaging.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Wei Sang, Songfeng Huang, Jiajie Chen, Xiaoqi Dai, Haoyu Liu, Youjun Zeng, Teliang Zhang, Xueliang Wang, Junle Qu, Ho-Pui Ho, Yonghong Shao
Summary: We designed a multi-channel P-SPR imaging (mcP-SPRi) sensing platform to overcome the limitations of small dynamic detection range and complex device configuration in P-SPR sensors. By developing a wavelength sequential selection (WSS) technique, the optimal sensing wavelengths can be selected based on the refractive indexes of the samples, eliminating the inconsistency in SPR signal response for different biomolecule types. Moreover, the individual SPR phase image acquisition time has been greatly reduced to 1s, enabling high-throughput mcP-SPRi sensing.
Article
Physics, Applied
Yuzhang Liang, Xinran Wei, Shuwen Chu, Xin Zhang, Yurui Fang, Wei Peng
Summary: Simultaneous observation of Tamm plasmon (TP) and surface plasmon (SP) resonances has attracted attention for improving sensing performance and broadening the application field of plasmonic biosensors. However, current methods require bulky and complicated setups, limiting miniaturization and integration. In this study, a nanograting-coupled plasmonic-photonic multilayer structure potentially integrated on the optical fiber tip is proposed, enabling the simultaneous excitation of TP and SP modes by utilizing diffraction light. The proposed structure offers self-reference sensing and rapid determination of refractive index.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2023)
Article
Geosciences, Multidisciplinary
Daniel C. Bowden, Andreas Fichtner, Thomas Nikas, Adonis Bogris, Christos Simos, Krystyna Smolinski, Maria Koroni, Konstantinos Lentas, Iraklis Simos, Nikolaos S. Melis
Summary: Distributed Acoustic Sensing (DAS) and integrated MFFI system are two popular methods for observing seismic wavefields, which acquire strain information from fiber-optic cables in different ways. This paper quantitatively compares these two methods through theoretical study and practical experiments, highlighting the importance of sensitivity depending on curvature points.
GEOPHYSICAL RESEARCH LETTERS
(2022)
Article
Nanoscience & Nanotechnology
Meryem Belkilani, Carole Farre, Yves Chevalier, Sylvain Minot, Francois Bessueille, Adnane Abdelghani, Nicole Jaffrezic-Renault, Carole Chaix
Summary: In this study, a phospholipid-based liposome layer was used as a biomimetic membrane model to investigate the binding between the pH-dependent fusogenic peptide from the influenza virus and the liposomes. The interaction was monitored using a multiparameter surface plasmon resonance approach, and it was found that the peptide could enter the lipid bilayer of liposomes at acidic pH, inducing vesicle swelling, while no insertion of the peptide was observed at alkaline pH, causing liposome contraction.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Optics
Soocheol Kim, Jin Hwa Ryu, Hoesung Yang, Kyuwon Han, Hyunseok Kim, Kwangsoo Cho, Soyoung Park, Sang Gi Hong, Kangbok Lee
Summary: This paper presents a spectrometer-based surface plasmon resonance imaging (SPRi) technique without mechanical scanning. A polarized broadband light source illuminates an object via a gold-coated prism, and the reflected light is spatially modulated by a digital mirror device (DMD) and measured with a spectrometer. Reflectance spectral images are reconstructed using the Hadamard transform (HT), and a refractive index (RI) map is visualized by analyzing the resonance peak shift at each image pixel. The method is demonstrated to have high resolution, sensitivity, and dynamic detection range, with experimental results validating the simulations.
Article
Optics
Siqing Dai, Jingyu Mi, Jiazhen Dou, Tongyao Yu, Mengmeng Zhang, Jianglei Di, Jiwei Zhang, Jianlin Zhao
Summary: In this study, a dual-wavelength surface plasmon resonance holographic microscopy (SPRHM) is proposed to measure the cell-substrate distance and cytoplasm refractive index simultaneously. The method utilizes phase-contrast surface plasmon resonance (SPR) images to demodulate the distributions of cell-substrate distance and cytoplasm refractive index. Experimental measurements on MDA-MB-231 cells and IDG-SW3 cells validate the feasibility of this approach, which provides a valuable tool in biological research.
Article
Optics
Yaru Li, Weihao Liu, Runcheng Liu, Jinjuan Gao, Jingwen Feng, Shicai Xu, Zhen Li, Shouzhen Jiang, Xuejian Du
Summary: The development of a portable biosensor for fast and convenient detection of human glucose levels is of critical significance to human health testing. This study developed a Cu-TCPP 2D MOF-sensitized ARC/Ag optical fiber SPR sensor, which overcame weak coupling and non-uniform plasmon resonance. The sensor exhibited enhanced sensitivity and figure of merit, and a linear response factor of 9.99 nm/(mg/mL) for glucose detection.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Chemistry, Physical
Esmaeil Rahimi, Reuven Gordon
Summary: The study applies Bethe's theory to analyze the transmission of a subwavelength aperture in a metal film, treating it as a combination of a magnetic dipole and electric dipole for linear and nonlinear optics. The research shows that at angled incidence, the Lorentz force dominates the second harmonic generation, and matches well with the angular dependence of the magnetic and electric dipoles.
Article
Instruments & Instrumentation
Xinchen Deng, Kirsty Milligan, Ramie Ali-Adeeb, Phillip Shreeves, Alexandre Brolo, Julian J. Lum, Jeffrey L. Andrews, Andrew Jirasek
Summary: Raman spectroscopy, when combined with GBR-NMF-RF framework, can be a powerful tool in monitoring radiation response profiles and biochemical dynamics in different molecular histotypes of irradiated breast cancer cells. The framework yields high accuracy, sensitivity, and specificity in classifying molecular histotypes and assessing the importance of Raman biochemical basis spectra for each classification test. High contributions from glycogen and lipids were found to be important in molecular histotype classifications.
APPLIED SPECTROSCOPY
(2022)
Article
Chemistry, Physical
Zohreh Sharifi, Reuven Gordon
Summary: The impact of loss on plasmonic resonances in metal-insulator-metal slits was analyzed, with a particular focus on its effect on the reflection phase. Reflection was calculated using single mode matching theory with the unconjugated form of the orthogonality relation. The reflection phase significantly influences the plasmonic resonance wavelengths, which were calculated using Fabry-Perot theory and compared with experimental results and simulations.
Article
Chemistry, Physical
Nathan C. Lindquist, Ariadne Tuckmantel Bido, Alexandre G. Brolo
Summary: This paper investigates the mechanism of fluctuations in Surface Enhanced Raman Spectroscopy (SERS) signals and finds that the underlying source of these fluctuations is a complex interplay of different effects. High-speed SIF activity is present in both dry and wet nanoparticle environments, and a simple model is proposed to explain the contributions to the fluctuations.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Analytical
Pearl Thompson, Ana Livia de Carvalho Bovolato, Gisela Ibanez-Redin, Alexandre G. Brolo
Summary: A rapid lateral flow screening tool using saliva samples and cell phone quantification has been developed, providing sensitive detection of IgG antibodies against SARS-CoV-2 within 10 minutes.
Article
Chemistry, Analytical
Ariadne Tuckmantel Bido, Alexandre G. Brolo, Arash Azarakhshi
Summary: Surface-enhanced Raman scattering (SERS) is a sensitive spectroscopic technique, but its reproducibility has been an issue in analytical chemistry applications. This study demonstrates that reliable quantification of SERS immunoassay at low concentrations is possible with careful experimental design and appropriate data analysis statistics.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Minh-Hai Tran, Ian Booth, Bruno G. daFonseca, Peter Berrang, Jeremy E. Wulff, Alexandre G. Brolo
Summary: An economical and facile method has been developed to synthesize a precursor for carbon films and materials. This precursor can be easily coated onto substrates and converted into a graphitic-like structure after mild thermal treatment. This method allows for the coating of glass surfaces of different shapes and forms.
Article
Chemistry, Multidisciplinary
Makayla M. Schmidt, Emily A. Farley, Marit A. Engevik, Trey N. Adelsman, Ariadne Tuckmantel Bido, Nathan D. Lemke, Alexandre G. Brolo, Nathan C. Lindquist
Summary: The concept of plasmonic hotspots is central to nanophotonics, specifically in surface-enhanced Raman scattering (SERS). SERS signals from single molecules often exhibit fluctuations, challenging the concept of static hotspots. Recent experiments have shown SERS intensity fluctuations (SIFs) to occur over a wide range of timescales due to various physical mechanisms causing SERS and the dynamic nature of light-matter interaction. This study presents a high-speed acquisition system that captures SERS spectra with microsecond time resolution, revealing that high-speed SIF events occur with relatively equal probability over a broad spectral range.
Article
Instruments & Instrumentation
Kirsty Milligan, Kendra Scarrott, Jeffrey L. Andrews, Alexandre G. Brolo, Julian J. Lum, Andrew Jirasek
Summary: Raman spectroscopy is a useful tool for obtaining biochemical information, but interpreting the data can be challenging. Our group has demonstrated a non-negative matrix factorization framework as an alternative to dimensionality reduction techniques for Raman spectroscopy data related to radiation response monitoring. We evaluated the accuracy of the model in reconstructing mixture solutions of known concentrations and considered factors such as spectral bases, noise thresholds, and different biochemical groups. Overall, the model performed well and solid bases spectra were comparable to solution bases spectra. The inclusion of an unconstrained component did not significantly affect the deconstruction, as long as all biochemicals were included in the model.
APPLIED SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Moyra F. Vieira, Ana Livia de Carvalho Bovolato, Bruno G. da Fonseca, Celly M. S. Izumi, Alexandre G. Brolo
Summary: A biosensor was developed for directly detecting human immunoglobulin G (IgG) and adenosine triphosphate (ATP) using gold nanoparticles/polystyrene-b-poly(2-vinylpyridine) (AuNP/PS-b-P2VP) nanocomposites. The substrates were functionalized with carboxylic acid groups to bind anti-IgG and anti-ATP and detect IgG and ATP. SEM images showed gold nanoparticles adsorbed onto a porous thin film. UV-VIS and SERS were used to characterize substrate functionalization and antibody-target interaction. PCA discriminated between samples before and after affinity tests. The biosensor was sensitive to IgG concentrations with a limit of detection of 1 μg/mL.
Article
Spectroscopy
Bruno G. daFonseca, Sapanbir S. Thind, Ian Booth, Alexandre G. Brolo
Summary: Principal component analysis (PCA) and linear discriminant analysis (LDA) were used to classify different types of carbon material based on their Raman spectra, providing an avenue for automated classification of carbon materials using Raman spectroscopy and machine learning.
JOURNAL OF RAMAN SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Minh-Hai Tran, Ian Booth, Arash Azarakhshi, Peter Berrang, Jeremy Wulff, Alexandre G. Brolo
Summary: This paper introduces a new method for large-scale synthesis of graphene that minimizes the creation of structural defects. The method involves hydrogen functionalization of graphite followed by thermal dehydrogenation, and it is demonstrated to be effective for the preparation of high-quality graphene films.
Article
Chemistry, Analytical
Ariadne Tuckmantel Bido, Katherine J. I. Ember, Dominique Trudel, Madeleine Durand, Frederic Leblond, Alexandre G. Brolo
Summary: The SARS-CoV-2 pandemic has posed a challenge in containing the spread of the virus, especially in low and middle-income countries due to limited access to screening tests. In this study, a low-cost biosensor device based on localized surface plasmon resonance (LSPR) was developed for the screening of SARS-CoV-2. The sensor showed high sensitivity and specificity in detecting the virus in saliva samples, providing a potential solution for screening challenges in underserved communities.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Multidisciplinary
Makayla M. Schmidt, Emily A. Farley, Marit A. Engevik, Trey N. Adelsman, Ariadne Tuckmantel Bido, Nathan D. Lemke, Alexandre G. Brolo, Nathan C. Lindquist
Summary: The concept of plasmonic hotspots plays a crucial role in the field of nanophotonics, particularly in surface-enhanced Raman scattering (SERS). Recent experiments have shown that these hotspots exhibit significant fluctuations at different timescales, which are likely caused by the complex interplay of multiple effects. This study presents a high-speed acquisition system that captures the dynamic processes of SERS fluctuations and finds that these fluctuations occur over a wide spectral range.
Article
Chemistry, Analytical
Xinchen Deng, Kirsty Milligan, Alexandre Brolo, Julian J. Lum, Jeffrey L. Andrews, Andrew Jirasek
Summary: The use of Raman spectroscopy combined with a data analytical framework allows for the monitoring of biochemical responses and spatial correlation with hypoxic regions in radiation therapy. This provides a deeper understanding of individual biochemical dynamics in radiation responses, which can be applied in cancer therapy.
