期刊
JOURNAL OF MICROENCAPSULATION
卷 29, 期 7, 页码 695-705出版社
INFORMA HEALTHCARE
DOI: 10.3109/02652048.2012.686526
关键词
chemoembolisation; drug-eluting microspheres; tripolyphosphate complexation; release; doxorubicin
资金
- Mid-career Researcher Program through NRF grant
- MEST [2010-0027798]
The aims of this study were to design and characterise doxorubicin-loaded chitosan microspheres for anticancer chemoembolisation. Doxorubicin-loaded chitosan microspheres were prepared by emulsification and cross-linking methods. Doxorubicin-chitosan solution was initially complexed with tripolyphosphate (TPP) to improve drug loading capabilities. Doxorubicin-loaded chitosan microspheres were highly spherical and had approximately diameters of 130-160 mm in size. Drug loading amount and loading efficiency were in the range 3.7-4.0% and 68.5-85.8%, respectively, and affected by TPP concentration, drug levels and cross-linking time. Doxorubicin release was affected by TPP complexation, cross-linking time and release medium. Especially, lysozyme in release media considerably increased drug release. Synergistic anti-cancer activities of doxorubicin-releasing chitosan microspheres were confirmed to VX2 cells in the rabbit auricle model compared with blank microspheres. Doxorubicin-loaded chitosan microspheres can efficiently be prepared by TPP gelation and cross-linking method and developed as multifunctional anti-cancer embolic material.
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