Article
Pharmacology & Pharmacy
Nahid S. Awad, Mohamed Haider, Vinod Paul, Nour M. AlSawaftah, Jayalakshmi Jagal, Renu Pasricha, Ghaleb A. Husseini
Summary: The study successfully encapsulated hydrophilic graphene quantum dots in stealth liposomes and triggered their release using low-frequency ultrasound, providing an effective method to deliver QDs to tumor cells while reducing systemic toxicity.
Article
Chemistry, Multidisciplinary
Maximilian Regenold, Kan Kaneko, Xuehan Wang, H. Benson Peng, James C. Evans, Pauric Bannigan, Christine Allen
Summary: Triggered drug delivery strategies, such as thermosensitive liposomes, have shown improved targetability for chemotherapeutics. However, most studies have focused on doxorubicin encapsulation, while other drugs could also benefit from this targeted delivery approach.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Alexander Rysin, Michael Paal, Wouter J. M. Lokerse, Barbara Wedmann, Martin Hossann, Michael Vogeser, Gerhard Winter, Lars H. Lindner
Summary: HePC can be accelerated to enter cancer cells through TSL carrier under mild hyperthermia conditions, and there is a rapid but incomplete release process in serum. Short heating or BSA can speed up the release of HePC in DPPG(2)-TSL, while MLV has strong extraction ability, which may affect the release and circulation of HePC.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Review
Pharmacology & Pharmacy
Maryam Chaudhry, Paul Lyon, Constantin Coussios, Robert Carlisle
Summary: This article evaluates the progress of thermolabile drug carrier systems in pre-clinical and clinical settings, as well as the modalities used to trigger drug release. The combined application of mild hyperthermia and heat-responsive liposomal drug carriers shows great potential utility, and ongoing clinical trials aim to refine this approach for optimal patient benefit.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Chemistry, Multidisciplinary
Lukas Christian Sebeke, Juan Daniel Castillo Gomez, Edwin Heijman, Pia Rademann, Alexandra Claudia Simon, Sandra Ekdawi, Susan Vlachakis, Dennis Toker, Ben Lasse Mink, Claudia Schubert-Quecke, Sin Yuin Yeo, Patrick Schmidt, Christina Lucas, Susanne Brodesser, Martin Hossann, Lars H. Lindner, Holger Gruell
Summary: In this article, the localized release of doxorubicin (DOX) from thermosensitive liposomes was achieved using MR-HIFU mediated hyperthermia in a swine model. The study showed a significant increase in DOX concentration in the muscle tissue after hyperthermia treatment, and there was a correlation between the pharmacokinetics of DOX in the bloodstream and its accumulation in the target tissue.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Oncology
Krishna K. Ramajayam, Danforth A. Newton, Dieter Haemmerich
Summary: This study developed a computational model to predict the potential efficacy of drugs when used with triggered drug delivery systems. In vitro experiments were conducted to obtain drug uptake and cytotoxicity data, which were incorporated into the model. The results showed that drugs with rapid cell uptake had higher tumor drug uptake but reduced perivascular drug penetration. Combining in vitro experiments with the computer model could provide a powerful screening tool for evaluating the potential efficacy of candidate drugs.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Biotechnology & Applied Microbiology
Xiaohong Chen, Jianfeng Zhang, Yan Yu, Haoran Wang, Genshan Ma, Di Wang, Hanzhong Cao, Jianping Yang
Summary: Ultrasound-triggered Lido-PPIX@ER hydrogel offers controlled release of lidocaine for the management of postoperative pain, providing individualized and timed relief.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Puja Gangurde, Mohammad Mahmoudzadeh, Zahra Gounani, Artturi Koivuniemi, Patrick Lauren, Tatu Lajunen, Timo Laaksonen
Summary: This study investigated the impact of different lipids on cationic light-activated liposomes and found that selecting the appropriate lipids is crucial for achieving stable and responsive liposomes.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Conor Lanphere, Jonah Ciccone, Adam Dorey, Nora Hagleitner-Ertugrul, Denis Knyazev, Shozeb Haider, Stefan Howorka
Summary: Chemistry plays a crucial role in synthesizing biomolecular structures. This study focuses on designing a triggerable synthetic nanopore using defined DNA blocks, which integrates multiple functions of biological membrane proteins. Through analysis, the kinetics and structural dynamics of DNA assembly at the membrane interface are revealed.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Stephen D. P. Fielden, Matthew J. Derry, Alisha J. Miller, Paul D. Topham, Rachel K. O'Reilly
Summary: Biological cells are surrounded by phospholipid membranes to retain their contents. The fusion of phospholipid membranes mediates the movement of material within and between cells, allowing mixing of contents or excretion of material. While biological membrane fusion is well-studied, the controlled fusion of polymer-based membranes is largely unexplored. In this study, triggered polymersome fusion was demonstrated using out-of-equilibrium polymersomes formed by ring-opening metathesis polymerization-induced self-assembly, which persist until a specific chemical signal triggers their fusion. This research is important for developing communication methods between polymersomes and emulating life-like behaviors in synthetic nanotechnology.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Acoustics
Harshani Iresha, Takaomi Kobayashi
Summary: A ultrasound-triggered nicotine release system was developed using a cellulose hydrogel drug carrier, showing that cellulose concentration had significant impact on nicotine release efficiency; hydrogels prepared with 0.9 wt% cellulose exhibited the best nicotine release performance under ultrasound irradiation.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Charles Izuchukwu Ezekiel, Alain Murhimalika Bapolisi, Roderick Bryan Walker, Rui Werner Macedo Krause
Summary: The study investigated the effects of ultrasound on echogenic 5-FU encapsulated crude soy liposomes for potential improvements in colorectal cancer treatment. The results showed spherical liposomes with high encapsulation efficiency and controlled release of 5-FU, providing encouraging prospects for managing drug-resistant colorectal cancer.
Article
Instruments & Instrumentation
Maximilian Regenold, Xuehan Wang, Kan Kaneko, Pauric Bannigan, Christine Allen
Summary: Chemotherapy plays a significant role in shrinking tumors, treating residual diseases, and addressing metastatic diseases. Advanced drug delivery strategies, such as thermosensitive liposome-mediated drug delivery, have emerged to offer more targeted approaches. However, the risk of overlooking metastatic spread remains. This study explores the combination of thermosensitive liposomes, localized mild hyperthermia, and immune checkpoint inhibition therapy to enhance systemic treatment capabilities.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Nicola Ingram, Laura E. McVeigh, Radwa H. Abou-Saleh, Damien V. B. Batchelor, Paul M. Loadman, James R. McLaughlan, Alexander F. Markham, Stephen D. Evans, P. Louise Coletta
Summary: Advanced drug delivery systems, such as ultrasound-mediated drug delivery, have the potential to increase the therapeutic index. This study investigates the effect of altering ultrasound parameters on drug delivery and finds that a short tone burst provides the best parameters for tumoral drug delivery.
Article
Biotechnology & Applied Microbiology
Chen Qin, Shimin Wen, Fan Fei, Yuemei Han, Haiting Wang, Hao Chen, Quankui Lin
Summary: By using a low-power NIR-triggered thermosensitive intraocular lens (IOL) that combines controlled drug release and phototherapy, the proposed IDG@P(NIPAM-co-AA)-IOL demonstrates excellent synergistic drug-phototherapy effect and prevents posterior capsule opacification (PCO). It serves as a promising platform for enhancing therapeutic potential and medication safety in future clinical applications of PCO treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Maryam T. Hussain, Neil Forbes, Yvonne Perrie, Kiran P. Malik, Chinwe Duru, Paul Matejtschuk
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Immunology
Carla B. Roces, Maryam T. Hussain, Signe T. Schmidt, Dennis Christensen, Yvonne Perrie
Article
Chemistry, Medicinal
Thomas J. Dennison, Julian C. Smith, Raj K. S. Badhan, Afzal R. Mohammed
JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Review
Infectious Diseases
Muhammad Idrees, Afzal R. Mohammad, Nazira Karodia, Ayesha Rahman
Article
Pharmacology & Pharmacy
Craig Russell, Majad Hussain, David Huen, Ayesha S. Rahman, Afzal R. Mohammed
Summary: This study explores the use of DNA microarrays as a high throughput screening tool to identify markers for predicting bioavailability and formulation-driven physiological responses. Significant changes in gene expression were found as a result of formulation exposure, including genes related to drug transport and metabolism.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Annsar Ahmad Warraich, Afzal Ur Rahman Mohammed, Hazel Gibson, Majad Hussain, Ayesha Sabah Rahman
Summary: Antimicrobial resistance is a global threat to public health. Amino acids may serve as antimicrobial adjuvants using alternate mechanisms to combat resistance, inhibiting bacterial growth and reducing the production of toxic pigments.
Article
Pharmacology & Pharmacy
Abdul Latif Ershad, Ali Rajabi-Siahboomi, Shahrzad Missaghi, Daniel Kirby, Afzal Rahman Mohammed
Summary: This study developed a fast, cost-effective, and repeatable swallowability ranking method to screen the in vitro swallowability of solid oral medicines, aiming to assist formulators and the pharmaceutical industry in developing easy-to-swallow formulations.
Article
Cell Biology
Habtom Ftuwi, Rheinallt Parri, Afzal R. Mohammed
Summary: This study developed a comprehensive method to fully characterize long-term cultured bovine taste bud cells, showing that these cells express taste receptor genes and can respond to taste stimuli such as denatonium and quinine. Gene expression analysis and bioinformatics research revealed that some genes in bovine taste bud cells have higher similarity to human counterparts, offering a cell-based system to study human taste transduction and potentially replace animal experimentation.
Article
Pharmacology & Pharmacy
Dilawar Khan, Daniel Kirby, Simon Bryson, Maryam Shah, Afzal Rahman Mohammed
Summary: Due to anatomical and physiological differences between pediatric subsets, it is well established that children respond differently to drugs compared to adults. Orally disintegrating mini-tablets have been considered an age-appropriate formulation option for pediatric use due to their dose flexibility and superior stability.
Article
Pharmacology & Pharmacy
Dilawar Khan, Daniel Kirby, Simon Bryson, Maryam Shah, Afzal Rahman Mohammed
Summary: This article discusses the factors affecting the safety, toxicity, and efficacy of pediatric drug delivery systems, as well as the anatomical and physiological differences between children and adults. It evaluates the advantages, limitations, and acceptability of current pediatric dosage forms, and explores techniques to overcome barriers associated with non-adherence to pediatric medications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Olaitan Abiona, David Wyatt, Jasdip Koner, Afzal Mohammed
Summary: This review explores the effects of particle properties on drug-carrier interactions in the preparation of a dry powder inhaler formulation. It is challenging to establish a direct cause-and-effect relationship between carrier properties and DPI formulation performance due to their interactive effects. Alpha lactose monohydrate remains the most commonly used carrier. The role of surface energetics in the optimization of dry powder inhaler formulations is discussed, along with various lactose particle modification methods.
Article
Pharmacology & Pharmacy
Dilawar Khan, Raj Badhan, Daniel J. J. Kirby, Simon Bryson, Maryam Shah, Afzal Rahman Mohammed
Summary: The rapid onset of action of nifedipine can cause a sudden decrease in blood pressure, resulting in adverse effects related to sympathetic nervous system activation. However, there are currently no approved modified release formulations of nifedipine for pediatric use, leading to a lack of pharmacokinetic data in this population. The use of pharmacokinetic modeling, particularly physiological-based pharmacokinetics (PBPK), has revolutionized the ability to predict drug pharmacokinetics in children and support drug licensing and dosing.
Review
Immunology
Kyprianos Michaelides, Maruthi Prasanna, Raj Badhan, Afzal-Ur-Rahman Mohammed, Adam Walters, M. Keith Howard, Pawan Dulal, Ali Al-Khattawi
Summary: Introduction With a limited global supply of vaccines and increasing vaccine hesitancy, improving vaccination coverage is a priority. The review focuses on the development of single administration vaccines (SAVs) and the challenges in their formulation. Case studies on hepatitis B and polio vaccines’ SAV formulations are discussed, along with their development challenges and preclinical data. Expert opinion: Although there have been efforts in SAV development, few have advanced to Phase-I trials. Overcoming commercial and technical barriers may facilitate the progress of SAVs, especially with the renewed global focus on vaccines since the COVID-19 pandemic.
EXPERT REVIEW OF VACCINES
(2023)
Article
Materials Science, Biomaterials
Saphia A. L. Matthew, John D. Totten, Suttinee Phuagkhaopong, Gemma Egan, Kimia Witte, Yvonne Perrie, F. Philipp Seib
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Pharmacology & Pharmacy
Maryam Tabassum Hussain, Mattia Tiboni, Yvonne Perrie, Luca Casettari
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
