Article
Pharmacology & Pharmacy
Conor O'Mahony, Ryan Sebastian, Fjodors Tjulkins, Derek Whelan, Andrea Bocchino, Yuan Hu, Joe O'Brien, Jim Scully, Margaret Hegarty, Alan Blake, Ines Slimi, A. James P. Clover, Alexander Lyness, Anne-Marie Kelleher
Summary: This paper describes a method for fabricating arrays of hollow silicon microneedles using only two bulk silicon etches. The microneedle arrays show biomechanical reliability and have the potential to be used for transdermal delivery and diagnostics.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemical Research Methods
Usanee Detamornrat, Marc Parrilla, Juan Dominguez-Robles, Qonita Kurnia Anjani, Eneko Larraneta, Karolien De Wael, Ryan F. Donnelly
Summary: A new drug delivery technology combining iontophoresis with hollow microneedles has been developed to improve transdermal drug delivery. Experiments have shown significant enhancement in drug permeation using this technology, and different delivery profiles can be achieved for different types of drugs. This technology has the potential to improve personalized dosing and enhance precision medicine.
Review
Pharmacology & Pharmacy
Alvaro Carcamo-Martinez, Bronach Mallon, Juan Dominguez-Robles, Lalitkumar K. Vora, Qonita K. Anjani, Ryan F. Donnelly
Summary: Microneedles have the potential to be a highly progressive device for drug delivery and monitoring purposes by penetrating the skin and piercing the stratum corneum barrier. Hollow microneedles have entered the pharmaceutical market as medical devices, with continuous development in materials and methods for fabrication, and expanding applications in drug delivery, vaccine delivery, and monitoring.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Alvaro Carcamo-Martinez, Bronach Mallon, Qonita Kurnia Anjani, Juan Dominguez-Robles, Emilia Utomo, Lalit K. Vora, Ismael A. Tekko, Eneko Larraneta, Ryan F. Donnelly
Summary: Autoimmune-mediated inflammatory skin diseases such as psoriasis, alopecia areata, and vitiligo can significantly impact patients' quality of life. Treatment with systemic steroids is common but may not always be successful. Recent studies have shown promising results with oral Janus Kinase (JAK) inhibitors, although they come with frequent side effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Yingjie Ren, Junshi Li, Yiwen Chen, Jing Wang, Yuxuan Chen, Zhongyan Wang, Zhitong Zhang, Yufeng Chen, Xiaoyi Shi, Lu Cao, Jiayan Zhang, Huang Dong, Cong Yan, Zhihong Li
Summary: Microneedles, especially hollow microneedles (HMNs), are crucial for drug delivery. However, current HMNs are mainly manufactured using silicon microfabrication, which lacks a low-cost and batch-scale customized approach, especially for flexible substrate HMNs. This study proposes using a high-precision 3D printed master mold and a dual-molding process to prepare HMNs with different shapes and sizes. The reuse of the molds significantly reduces costs. The drug delivery efficiency of the fabricated HMNs was verified through in situ treatment of psoriasis in mice, which resulted in reduced side effects and drug toxicity. This dual-molding process can revitalize HMNs development.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Suman Pahal, Kedar Badnikar, Vivek Ghate, Utkarsh Bhutani, Mangalore Manjunatha Nayak, Dinesh Narasimhaiah Subramanyam, Praveen Kumar Vemula
Summary: This review discusses the recent advances in microneedle-based devices for sustained release of vaccines, hormones, and antiretrovirals, emphasizing the importance of designing slow-degrading polymeric matrices or providing physiochemical triggers for on-demand drug release. These long-acting transdermal devices help prevent burst release of drugs, ensuring efficient drug delivery.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Biochemical Research Methods
Yi Xuan, Subhadip Ghatak, Andrew Clark, Zhigang Li, Savita Khanna, Dongmin Pak, Mangilal Agarwal, Sashwati Roy, Peter Duda, Chandan K. Sen
Summary: Tissue nanotransfection (TNT) is an electromotive gene transfer technology developed for tissue reprogramming in vivo, utilizing silicon hollow-needle arrays for precise plasmid delivery to murine skin without the need for viral vectors.
Article
Pharmacology & Pharmacy
Vivek Yadav, Peeyush Kumar Sharma, Upadhyayula Suryanarayana Murty, Narayan H. Mohan, Rajendran Thomas, Santosha Kumar Dwivedy, Subham Banerjee
Summary: A 3D printed assembly of hollow microneedles, designed and manufactured using stereolithography technology, was used for transdermal delivery of high molecular weight antibiotics. The microneedles were designed with sub-apical holes for improved mechanical strength, and were characterized for quality and uniformity. Ex vivo and in vivo experiments confirmed the efficient penetration and desired bioavailability of the antibiotic.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Iakovos Xenikakis, Konstantinos Tsongas, Emmanouil K. Tzimtzimis, Orestis L. Katsamenis, Efterpi Demiri, Constantinos K. Zacharis, Despoina Georgiou, Eleni P. Kalogianni, Dimitrios Tzetzis, Dimitrios G. Fatouros
Summary: Hollow microneedles (HMNs) were fabricated using vat polymerization method for transdermal delivery of insulin. The mechanical characteristics and skin penetration of two different geometries of HMNs were analyzed experimentally and through simulation. The results suggest that the shape of the microneedles can potentially impact the transport of insulin.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Isabella Villota, Paulo C. Calvo, Oscar Campo, Faruk Fonthal
Summary: This article presents an analysis of microneedles, including the design parameters, mathematical modeling, mechanical simulations, and ANSYS software analysis. The results show that the microneedle designed in this study has promising features for transdermal drug delivery, and a 3D printed prototype was successfully made using a bio-compatible resin of class 1.
Article
Materials Science, Multidisciplinary
Pooyan Makvandi, Rezvan Jamaledin, Guojun Chen, Zahra Baghbantaraghdari, Ehsan Nazarzadeh Zare, Concetta Di Natale, Valentina Onesto, Raffaele Vecchione, Jesse Lee, Franklin R. Tay, Paolo Netti, Virgilio Mattoli, Ana Jaklenec, Zhen Gu, Robert Langer
Summary: Microneedle (MN) patches, made up of miniature needles, have emerged as a promising tool for minimally invasive translocation of biomolecules into the dermis. Stimuli-responsive MN patches are a new drug delivery system that can release cargos in response to internal or external triggers, with various mechanisms of action for different indications. Future opportunities and challenges in clinical translation are also discussed.
Article
Multidisciplinary Sciences
Junhong Pu, Yuan Meng, Zhixin Xie, Zihang Peng, Jianghan Wu, Ye Shi, Roshan Plamthottam, Wei Yang, Qibing Pei
Summary: This study introduces an electrophoretic process to concentrate boron nitride nanosheets onto a designated electrode surface, forming a seamless bilayer structure with significant modulus difference, called the unimorph nanocomposite dielectric elastomer (UNDE). This material shows improved performance in terms of breakdown field strength and durability compared to conventional nanocomposite dielectric elastomers. Multiple UNDE units can be formed using a simple electrophoretic concentration process, and they can be used to create high-stroke actuators. The experimental disc-shaped actuator demonstrated the capability of a high-speed lens motor to vary the focal length of a two-lens system by 40 times.
Article
Chemistry, Multidisciplinary
Georgiana Dolete, Cristina Chircov, Ludmila Motelica, Denisa Ficai, Ovidiu-Cristian Oprea, Marin Gheorghe, Anton Ficai, Ecaterina Andronescu
Summary: This article introduces a method for drug delivery and actuating mechanism using a magnetic film to meet the demanding use of controlled drug delivery systems. Magnetic alginate films were prepared in the laboratory, and the hypothesis that the magnetic field can trigger drug release from the films was validated by studying the release process.
Article
Materials Science, Biomaterials
Zhiyong Zeng, Guohua Jiang, Yanfang Sun, Uladzislau E. Aharodnikau, Khaydar E. Yunusov, Xiaofei Gao, Tianqi Liu, Sergey O. Solomevich
Summary: In this study, a synergistically flexible microneedle dressing loaded with metformin and CaO2@PDA nanoparticles was developed for promoting diabetic wound healing. The microneedles effectively penetrated the diabetic rat skin, triggering a response to regulate blood glucose levels. The microneedle dressings also exhibited anti-inflammatory, oxygen supply, and exudate absorption properties. The results demonstrated that this microneedle system could serve as a promising approach for efficient wound healing in diabetic patients.
BIOMATERIALS SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Vivek Ghate, Anu Renjith, Kedar Badnikar, Suman Pahal, Shreyas N. Jayadevi, Manjunatha M. Nayak, Praveen K. Vemula, Dinesh N. Subramanyam
Summary: Polymeric hollow microneedle arrays (HMNs) were successfully fabricated using a novel single-step drop-casting process without the need for cleanroom facilities and sophisticated instrumentation. The optimized polymer solution allowed the reproducible formation of desired height HMNs on a detachable acrylic base, which was integrated into an experimental package for delivering multiple metered drug doses. The fabricated HMNs were tested for mechanical integrity and stability, and demonstrated successful delivery of vitamin B12 (ex vivo) and insulin (in vivo), showcasing the potential for large-scale manufacturing and wearable device development.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Mechanics
Tanja Roth, Lisa Sprenger, Stefan Odenbach, Urs O. Hafeli
Article
Materials Science, Multidisciplinary
Diana Zahn, Andreas Weidner, Zeynab Nosrati, Lucas Woeckel, Jan Dellith, Robert Mueller, Katayoun Saatchi, Urs O. Hafeli, Silvio Dutz
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2019)
Article
Materials Science, Multidisciplinary
Reka Geczy, Monica Agnoletti, Mikkel F. Hansen, Jorg P. Kutter, Katayoun Saatchi, Urs O. Hafeli
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francois Michaud, Ning Li, Rosalie Plantefeve, Zeynab Nosrati, Charles Tremblay, Katayoun Saatchi, Gerald Moran, Alexandre Bigot, Urs O. Hafeli, Samuel Kadoury, An Tang, Pierre Perreault, Sylvain Martel, Gilles Soulez
Article
Engineering, Biomedical
Ning Li, Yuting Jiang, Rosalie Plantefeve, Francois Michaud, Zeynab Nosrati, Charles Tremblay, Katayoun Saatchi, Urs O. Hafeli, Samuel Kadoury, Gerald Moran, Florian Joly, Sylvain Martel, Gilles Soulez
ANNALS OF BIOMEDICAL ENGINEERING
(2019)
Article
Engineering, Biomedical
Ning Li, Francois Michaud, Zeynab Nosrati, Dumitru Loghin, Charles Tremblay, Rosalie Plantefeve, Katayoun Saatchi, Urs O. Hafeli, Sylvain Martel, Gilles Soulez
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2019)
Article
Chemistry, Inorganic & Nuclear
Christian Buchwalder, Maria de Guadalupe Jaraquemada-Pelaez, Julie Rousseau, Helen Merkens, Cristina Rodriguez-Rodriguez, Chris Orvig, Francois Benard, Paul Schaffer, Katayoun Saatchi, Urs O. Hafeli
INORGANIC CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Thuy Tran, Peter Bonlokke, Cristina Rodriguez-Rodriguez, Zeynab Nosrati, Pedro Luis Esquinas, Nrupa Borkar, Jakob Plum, Sophie Strindberg, Stoyan Karagiozov, Thomas Rades, Anette Mullertz, Katayoun Saatchi, Urs O. Hafeli
JOURNAL OF CONTROLLED RELEASE
(2020)
Editorial Material
Materials Science, Multidisciplinary
Urs Hafeli, Silvio Dutz, Maciej Zborowski, Wolfgang Schutt
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2020)
Article
Immunology
Sahan A. Ranamukhaarachchi, Tullio Esposito, Mehrsa Raeiszadeh, Urs O. Hafeli, Boris Stoeber
Review
Pharmacology & Pharmacy
Tanya Saxena, Claire Sie, Kristine Lin, Daisy Ye, Katayoun Saatchi, Urs O. Hafeli
Summary: Peptides are small biomolecules that can stimulate or inhibit important functions in the human body. However, the clinical use of peptides through oral delivery is limited due to their sensitive structure and physiological barriers in the gastrointestinal tract. These barriers can be overcome by chemical and mechanical approaches, and nuclear imaging provides a better platform for observing the gastrointestinal transit and quantitative distribution of radiolabeled peptides. This review provides a brief background on the oral delivery of peptides and discusses how nuclear imaging can aid in the study of their gastrointestinal transit.
Article
Biochemical Research Methods
Reka Geczy, Drago Sticker, Nicolas Bovet, Urs O. Hafeli, Jorg P. Kutter
Article
Engineering, Biomedical
Pedro L. Esquinas, Cristina Rodriguez-Rodriguez, Tullio V. F. Esposito, Jeppe Harboe, Marta Bergamo, Anna Celler, Katayoun Saatchi, Vesna Sossi, Urs O. Hafeli
PHYSICS IN MEDICINE AND BIOLOGY
(2018)
Article
Engineering, Electrical & Electronic
Sahan A. Ranamukhaarachchi, Celestino Padeste, Urs O. Hafeli, Boris Stoeber, Victor J. Cadarso
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2018)
Article
Medicine, Research & Experimental
Jose Carlos De la Vega, Pedro Luis Esquinas, Cristina Rodriguez-Rodriguez, Mehrdad Bokharaei, Igor Moskalev, David Liu, Katayoun Saatchi, Urs O. Hafeli