Article
Gastroenterology & Hepatology
Maximilian Baumgartner, Rebecca Zirnbauer, Sabine Schlager, Daniel Mertens, Nikolaus Gasche, Barbara Sladek, Craig Herbold, Olga Bochkareva, Vera Emelianenko, Harald Vogelsang, Michaela Lang, Anton Klotz, Birgit Moik, Athanasios Makristathis, David Berry, Stefanie Dabsch, Vineeta Khare, Christoph Gasche
Summary: With increasing urbanization and industrialization, the prevalence of inflammatory bowel diseases (IBDs) has been rising over the past two decades. This study found that the emerging pathogen atypical enteropathogenic E. coli (aEPEC) is associated with disease activity in ulcerative colitis (UC) patients, and it may disrupt immune-microbiota homeostasis.
Article
Cell Biology
Emily Boucher, Luke Brown, Priyoshi Lahiri, Eduardo R. Cobo
Summary: This study showed that mice deficient in Cathelicidin had fewer recruited macrophages with impaired phagocytosis during acute Escherichia coli-induced peritonitis, which was attributed to endogenous functions of murine Cathelicidin CRAMP. Synthetic human Cathelicidin LL-37 did not improve phagocytosis in a murine phagocytic cell line, highlighting the differential roles between endogenous and exogenous Cathelicidins.
CELL AND TISSUE RESEARCH
(2021)
Article
Microbiology
Raisa Shtuhin-Rahav, Aaron Olender, Efrat Zlotkin-Rivkin, Etan Amse Bouman, Tsafi Danieli, Yael Nir-Keren, Aryeh M. Weiss, Ipsita Nandi, Benjamin Aroeti
Summary: This study found that specific EPEC type III secreted effectors, EspF and Map, can induce lytic host cell death and lysosomal exocytosis (LE), resulting in the secretion of lysosomal enzymes into the extracellular environment and the appearance of the lysosomal membrane protein, Lamp-1, on the infected cell surface. Meanwhile, an EPEC effector, EspZ, inhibits LE and protects against lytic cell death.
Article
Microbiology
Rie Ikeda, Keiji Nakamura, Marc Saulmont, Audrey Habets, Jean-Noel Duprez, Nicolas Korsak, Tetsuya Hayashi, Damien Thiry, Jacques G. Mainil
Summary: The aim of this study was to identify E. coli O80 in healthy cattle and determine its potential role in human and calf infections. 16 E. coli O80 strains were isolated from bulls and cows, but they were not identified as the melibiose non-fermenting E. coli O80:H2 strain. These isolates belonged to serotypes and sequence types O80:H6/ST8619 and O80:H45/ST4175, which were phylogenetically related to E. coli O80:H6 and O80:H45 from different animal species. Therefore, healthy adult cattle were not found to be a source of contamination by STEC or EPEC O80:H2 in humans and calves.
Article
Public, Environmental & Occupational Health
Jose A. Orden, Isidro Garcia-Menino, Saskia C. Flament-Simon, Jorge Blanco, Ricardo de la Fuente, Abel Martinez-Rodrigo, Alicia Mas, Javier Carrion, Francisco Sobrino, Gustavo Dominguez-Bernal
Summary: The study found a high prevalence of antimicrobial-resistant E. coli, including pathogenic strains, in raccoons from Madrid, Spain. These raccoons may pose a risk to public health due to their potential to contaminate food and the environment with their feces.
ZOONOSES AND PUBLIC HEALTH
(2021)
Review
Immunology
Christa Decker, Sudeshna Sadhu, Gabrielle Fredman
Summary: The resolution of inflammation is a tissue protective program governed by factors such as specialized pro-resolving mediators. Phagocytes like neutrophils and macrophages play key roles in this process by removing debris, microbes, and dead cells. Enhancing factors and mechanisms associated with phagocytosis and efferocytosis are critical for understanding and treating prevalent human diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Biomedical
Wenhao Cheng, Sundol Kim, Sandra Zivkovic, Hoyong Chung, Yi Ren, Jingjiao Guan
Summary: This study develops a technique for specifically labeling phagosome-derived vesicles in macrophages using microfabricated microparticles. The technique has the potential to advance our understanding of phagocytosis and generate widespread interest in the field of biomaterials science and engineering.
ACTA BIOMATERIALIA
(2022)
Article
Cell Biology
Wei Cai, Mengyan Hu, Chunyi Li, Ruizhen Wu, Danli Lu, Chichu Xie, Wei Zhang, Tiemei Li, Shishi Shen, Huipeng Huang, Wei Qiu, Quentin Liu, Yan Lu, Zhengqi Lu
Summary: Proper termination of cell-death-induced neural inflammation is crucial for tissue repair in acute ischemic stroke. FOXP3+ macrophages, a distinct subset of macrophages, display superactive phagocytic capacity and enhance macrophage metabolism through the facilitation of cargo metabolism. FOXP3+ macrophages could be a potential target for immunomodulatory therapy against acute ischemic stroke.
Article
Pharmacology & Pharmacy
Xinlei Tian, Min Guo, Xiaoya Zhang, Lingfeng Guo, Nan Lan, Yaojun Cheng, Yannan Han, Mingxin Wang, Zhonglu Peng, Changlin Zhou, Hongye Fan
Summary: This study investigated whether Strongylocentrotus nudus eggs polysaccharide (SEP), a non-toxic extract from seafood, contributes to host defense against bacterial infection. The results showed that SEP enhanced bacterial clearance by promoting phagocytosis by macrophages and protected mice from bacterial infection.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Adilene Olvera, Hannah Carter, Anubama Rajan, Lily G. Carlin, Xiaomin Yu, Xi-Lei Zeng, Samuel Shelburne, Micah Bhatti, Sarah E. Blutt, Noah F. Shroyer, Robert Jenq, Mary K. Estes, Anthony Maresso, Pablo C. Okhuysen
Summary: Enteropathogenic Escherichia coli (EPEC) role in cancer and immunocompromised patient diarrhea remains controversial. Quantitation of fecal bacterial loads can differentiate colonized from infected patients. Patients with EPEC had higher bacterial burden in immunosuppressed and those with specific genes. Majority of EPEC patients responded to antimicrobial therapy. Antimicrobial resistance and novel adherence patterns were observed, impacting cancer care in some patients.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Chemistry, Multidisciplinary
Jing-Yang Zhang, Fang -Man Chen, Rong Liu, Jia-Qi Luo, Yong-Cong Huang, Na Shu, Sui-Juan Zheng, Dan Shao, Kam W. Leong, Jin-Zhi Du
Summary: This study identified that the use of the toll-like receptor 7/8 agonist resiquimod (R848) can promote macrophage phagocytosis and reprogram them into an anti-tumoral phenotype. The combination with the anti-SIRP alpha antibody (aSIRP alpha) further enhances the pro-phagocytic effect. A nanoparticle-based delivery system was developed to deliver R848 and aSIRP alpha simultaneously, leading to improved macrophage-mediated cancer immunotherapy.
Article
Clinical Neurology
Keun Woo Park, Hyunwoo Ju, Il-Doo Kim, John W. Cave, Yang Guo, Wei Wang, Zhuhao Wu, Sunghee Cho
Summary: The study found that monocyte-derived macrophages (MDMs) play a role in the progressive stroke-induced injury and repair processes. Manipulating monocyte entry at different stroke stages may be an effective immune-based strategy to limit injury propagation in chronic stroke.
Article
Immunology
Hong Chen, Man-Li Tong, Li-Li Liu, Li-Rong Lin, Tian-Ci Yang
Summary: The study demonstrates that opsonic phagocytosis, nonopsonic phagocytosis, and active invasion are all involved in the interactions between T. pallidum and macrophages during syphilis, revealing an important aspect of T. pallidum pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yue Han, Minqi Liu, Ying Han, Naiyang Shi, Qiang Wang, Tingting Cui, Liuqing Yang, Xuefeng Zhang, Liguo Zhu, Huimin Qian, Hui Jin, Chen Dong
Summary: This study aimed to assess the public health significance of STEC and EPEC strains isolated from livestock in Jiangsu, China by determining their serotypes, virulence profiles, and genetic relationship with international STEC strains. The results showed diverse serotypes and virulence gene profiles in the STEC and EPEC strains, and some strains displayed genomic correlation with clinical isolates, indicating a potential threat to public health.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xiaodi Liu, Wenyue Zhang, Yanni Xu, Xiaolin Xu, Qiongchao Jiang, Jingliang Ruan, Ye Wu, Yingshi Zhou, Phei Er Saw, Baoming Luo
Summary: Residual tumors after insufficient radiofrequency ablation (IRFA) exhibit accelerated progression and anti-PD-1 resistance, with reports indicating that macrophages infiltrating into these tumors may be a contributing factor. The involvement of autophagic elements, particularly LC3, in residual tumors is being investigated to understand the mechanisms between LC3 and macrophages, aiming to enhance immunotherapy for these tumors.
