期刊
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
卷 22, 期 10, 页码 1336-1342出版社
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
DOI: 10.4014/jmb.1203.03059
关键词
Burkholderia; melioidosis; capsular polysaccharide; biofilm
资金
- Genomics and Molecular Biology Initiatives Programme of the Malaysia Genome Institute (GENOMalaysia), Ministry of Science, Technology and Innovation of Malaysia
- Universiti Sains Malaysia
In Burkholderia pseudomallei, the pathogen that causes melioidosis, the gene cluster encoding the capsular polysaccharide, is located on chromosome 1. Among the 19 capsular genes in this cluster, wzm has not been thoroughly studied. To study the function of wzm, we generated a deletion mutant and compared it with the wild-type strain. The mutant produced less biofilm in minimal media and was more sensitive to desiccation and oxidative stress compared with the wild-type strain, indicating that wzm is involved in biofilm formation and membrane integrity. Scanning electron microscopy showed that the bacterial cells of the mutant strain have more defined surfaces with indentations, whereas cells of the wild-type strain do not.
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