期刊
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
卷 19, 期 11, 页码 1288-1294出版社
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
DOI: 10.4014/jmb.0903.0112
关键词
Myxobacteria; fruiting body development; Myxococcus xanthus
资金
- Korean government (MEST) [R01-2005-000-10710-0, R012007-000-20438-0]
- National Research Foundation of Korea [R01-2005-000-10710-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We have used mutational analysis to identify four genes, MXAN3553, MXAN3554, MXAN3555, and MXAN3556, constituting an operon that is essential for normal fruiting body development in Myxococcus xanthus. Deletion of MXAN3553, which encoded a hypothetical protein, resulted in delayed fruiting body development. MXAN3554 was predicted to encode a metallopeptidase, and its deletion caused fruiting body formation to fail. Inactivation of MXAN3555, which encoded a putative NtrC-type response regulator, resulted in delayed aggregation and a severe reduction in sporulation. Fruiting bodies also failed to develop with the deletion of MXAN3556, another gene encoding a hypothetical protein.
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