期刊
JOURNAL OF MICROBIOLOGY
卷 51, 期 6, 页码 836-843出版社
MICROBIOLOGICAL SOCIETY KOREA
DOI: 10.1007/s12275-013-3521-y
关键词
Lactobacillus plantarum LBP-K10; culture filtrate; cis-cyclo(L-Leu-L-Pro); cis-cyclo(L-Phe-L-Pro); influenza A virus; antiviral activity
类别
资金
- NCIRF at Seoul National University
We isolated Lactobacillus plantarum LBP-K10 from the traditional Korean fermented food kimchi. When organic acids were removed, the culture filtrate of this isolate showed high antiviral activity (measured using a plaque-forming assay) against the influenza A (H3N2) virus. Two fractions that were active against influenza A virus were purified from the culture filtrate using a C18 column with high-performance liquid chromatography. These active fractions were crystallized and identified to be the cyclic dipeptides cis-cyclo (l-Leu-l-Pro) and cis-cyclo(l-Phe-l-Pro) using gas chromatography-mass spectrometry; this identification was confirmed by X-ray crystallography. These cyclic dipeptides were identified in the culture filtrate of other lactic acid bacteria, including Lactobacillus spp., Leuconostoc spp., Weissella spp., and Lactococcus lactis.
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