Article
Microbiology
Einat Seidel, Liat Dassa, Corinna Schuler, Esther Oiknine-Djian, Dana G. Wolf, Vu Thuy Khanh Le-Trilling, Ofer Mandelboim
Summary: The study reveals that the uncharacterized HCMV protein UL147A interferes with the immune response by downregulating the expression of the immune ligand MICA*008, hindering the elimination of HCMV-infected cells. This finding advances the understanding of complex HCMV immune evasion mechanisms and may facilitate the development of antiviral drugs and vaccines.
Article
Cell Biology
Milena Ivanova, Gergana Tsvetkova, Spaska Lessichkova, Nevena Gesheva, Evgueniy Hadjiev, Velizar Shivarov
Summary: JAK2 V617F-driven myeloproliferative neoplasms (MPNs) can evade immune surveillance by up-regulating PD-L1 and down-regulating HLA class I pathway. In addition, the role of major histocompatibility complex class I-related genes (MICA and MICB) in JAK2 V617F+ MPNs was assessed. Two protective alleles, MICA*008:01 and MICA*016, were identified through high resolution genotyping. MPN patients had increased levels of soluble sMICA molecules. Peripheral blood JAK2 V617F+ granulocytes showed higher surface expression of MICB, while the expression of MICA and MICB transcripts did not differ from normal granulocytes. MICA and MICB genes were down-regulated in JAK2 V617F+ CD34+ cells from primary myelofibrosis patients compared to normal CD34+ hematopoietic stem cells. These findings suggest that MICA and MICB genes play a minor but significant role in the development of MPNs, and targeted MICA approaches may be beneficial for certain patients.
Article
Cell Biology
Satu Koskela, Silja Tammi, Jonna Clancy, Jonathan A. M. Lucas, Thomas R. Turner, Kati Hyvarinen, Jarmo Ritari, Jukka Partanen
Summary: Genetic variation in MICA and MICB genes is associated with transplantation outcome, autoimmune diseases, and infections. This study analyzes the polymorphism and allele distribution of these genes in Finland, a population with historical bottleneck and founder effects. The results show population differences and a relatively high level of polymorphism in MICA and MICB genes, including the discovery of novel alleles with amino acid changes.
Article
Oncology
Shuo Wang, Guillaume C. Onyeaghala, Nathan Pankratz, Heather H. Nelson, Bharat Thyagarajan, Weihong Tang, Faye L. Norby, Chinenye Ugoji, Corinne E. Joshu, Christian R. Gomez, David J. Couper, Josef Coresh, Elizabeth A. Platz, Anna E. Prizment
Summary: The study found that MICA and MICB are associated with colorectal cancer development, and low sMICA levels are related to lower risk of colorectal cancer. These findings highlight the importance of immune surveillance in colorectal cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Medicine, General & Internal
Alena Machuldova, Lucie Houdova, Katerina Kratochvilova, Martin Leba, Pavel Jindra, Pavel Ostasov, Diana Maceckova, Robin Klieber, Hana Gmucova, Jiri Sramek, Monika Holubova
Summary: The study examined the impact of genetic variations in MICA-14 and MICB-58 on HSCT outcomes, finding a significant association between grafts from donors with MICA-14Gly allele and worsened patient overall survival, as well as a negative effect of MICB-58 polymorphism on relapse-free survival.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Imaniar Noor Faridah, Haafizah Dania, Rita Maliza, Wan-Hsuan Chou, Wen-Hung Wang, Yen-Hsu Chen, Dyah Aryani Perwitasari, Wei-Chiao Chang
Summary: Dengue is a global arboviral disease that has become a major public health concern. This study investigated the associations of variations in the MICB and PLCE1 genes with dengue severity and thrombocytopenia in Indonesian and Taiwanese populations. The results showed associations between MICB rs3132468 and dengue shock syndrome (DSS), as well as between PLCE1 rs3740360 and secondary dengue hemorrhagic fever (DHF) in Indonesian patients.
Article
Dentistry, Oral Surgery & Medicine
Milena Ivanova, Bushra Al Hadra, Stanislav Yordanov, Spaska Lesichkova, Hristo Stoyanov, Velizar Shivarov, Elitsa Deliverska
Summary: The study identified significant protective effects of MICB*002:01 and increased frequencies of MICB*018, *019, and *020 alleles in Oral Squamous Cell Carcinoma patients. A predisposing association for the MICA*008:01-MICB*019 haplotype was also observed. Correlations were found between functionally relevant MICA polymorphisms and soluble MICA levels.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Article
Hematology
Effie W. Petersdorf, Caroline McKallor, Mari Malkki, Meilun He, Stephen R. Spellman, Katharine C. Hsu, Roland K. Strong, Ted Gooley, Phil Stevenson
Summary: Gene variation of NKG2D receptor and its ligands MICA and MICB can affect relapse and survival after transplantation, providing insights for predicting transplantation failure.
Article
Biology
Wassan Jarrar, Sawsan Khdair, Feras A. Khudeir
Summary: The study suggests that MICA gene polymorphisms do not appear to be associated with increased susceptibility to T1D in the Jordanian population, except for a negative association with the MICA*011 allele.
Review
Cell Biology
Jagoda Siemaszko, Aleksandra Marzec-Przyszlak, Katarzyna Bogunia-Kubik
Summary: Natural Killer (NK) cells are natural cytotoxic cells of the innate immune system that can recognize and attack transformed or infected cells through their NKG2D receptor, which has significant immunological functions and clinical relevance.
Article
Biochemistry & Molecular Biology
Hironobu Yagishita, Hideaki Kagaya, Mitsuru Saito, Kazuyuki Numakura, Ryohei Yamamoto, Ryuichiro Sagehashi, Tomonori Habuchi, Shigeru Satoh, Masatomo Miura
Summary: The study evaluated the effects of NR1I2 and ABCB1 genetic polymorphisms on everolimus pharmacokinetics in Japanese renal transplant patients. The results showed significant correlations between different genotypes, gender, age, and liver function with the dose-adjusted AUC(0-12) of everolimus. Therefore, age and liver function should be considered when evaluating dose reductions for everolimus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Imene Handous, Naila Hannachi, Bechir Achour, Manel Marzouk, Olfa Hazgui, Abderrahim Khelif, Jalel Boukadida
Summary: The study revealed that mixed CMV genotypes were common, and multiple gB, gN, and gO genotypes were associated with clinical manifestations and higher viral load.
INFECTIOUS DISEASES AND THERAPY
(2021)
Article
Virology
Ki Mun Kwon, Young Eui Kim, Myoung Kyu Lee, Woo-Chang Chung, Seokhwan Hyeon, Minji Han, Dajeong Lee, Shuang Gong, Jin-Hyun Ahn
Summary: UL48 DUB mainly acts on the innermost tegument proteins pp150 and pUL48 itself during HCMV infection, and may play a role in protecting virions from the inclusion of ubiquitin conjugates.
JOURNAL OF VIROLOGY
(2021)
Review
Immunology
Alena Machuldova, Monika Holubova, Valentina S. Caputo, Miroslava Cedikova, Pavel Jindra, Lucie Houdova, Pavel Pitule
Summary: Natural killer cells (NK cells) play key roles in malignant diseases, particularly in acute myeloid leukemia. NK cell activity is influenced by signals received through binding of different ligands to activating or inhibitory receptors. NK cells eliminate transformed or infected cells by binding to NKG2D ligands, while target cells develop protective mechanisms to evade NK cell killing.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Abrar Ul Haq Khan, Melinda Blimkie, Doo Seok Yang, Mandy Serran, Tyler Pack, Jin Wu, Ji-Young Kang, Holly Laakso, Seung-Hwan Lee, Yevgeniya Le
Summary: LDR significantly influenced the proportion, proliferation, activation, and function of immune cells, particularly NK and T cells, but had no noticeable impact on mammary cancer development. The study also demonstrated the modulation of the cross-talk between NKG2D receptor and its ligands by LDR exposure at different time points.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Suwit Chaisri, James A. Traherne, Jyothi Jayaraman, Amornrat Romphruk, John Trowsdale, Chanvit Leelayuwat
Article
Hematology
P. Simtong, C. Puapairoj, C. Leelayuwat, S. Santoso, A. V. Romphruk
TRANSFUSION MEDICINE
(2018)
Article
Chemistry, Physical
Molin Wongwattanakul, Chariya Hahnvajanawong, Wunchana Seubwai, Chanvit Leelayuwat, Temduang Limpaiboon, Patcharee Jearanaikoon
JOURNAL OF MOLECULAR STRUCTURE
(2018)
Article
Oncology
Prinya Prasongdee, Patcharaporn Tippayawat, Temduang Limpaiboon, Chanvit Leelayuwat, Molin Wongwattanakul, Patcharee Jearanaikoon
Article
Biochemistry & Molecular Biology
Wisitsak Phoksawat, Amonrat Jumnainsong, Naruemon Leelayuwat, Chanvit Leelayuwat
MOLECULAR IMMUNOLOGY
(2019)
Article
Cell Biology
Pornsuda Maraming, Sompong Klaynongsruang, Patcharee Boonsiri, Shu-Fen Peng, Sakda Daduang, Chanvit Leelayuwat, Chamsai Pientong, Jing-Gung Chung, Jureerut Daduang
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Genetics & Heredity
Rungtiwa Nutalai, Silvana Gaudieri, Amonrat Jumnainsong, Chanvit Leelayuwat
Article
Multidisciplinary Sciences
Suwit Chaisri, Noel Pabalan, Sompong Tabunhan, Phuntila Tharabenjasin, Nipaporn Sankuntaw, Chanvit Leelayuwat
Article
Hematology
Roongaroon Phuangtham, Sentot Santoso, Chanvit Leelayuwat, Patcharee Komvilaisak, Haoqiang Ding, Amornrat V. Romphruk
Article
Biochemical Research Methods
Sukanya Srijampa, Surachat Buddhisa, Sawinee Ngernpimai, Chanvit Leelayuwat, Siriporn Proungvitaya, Apiwat Chompoosor, Patcharaporn Tippayawat
BIOCONJUGATE CHEMISTRY
(2020)
Article
Nutrition & Dietetics
Nisa Chuangchot, Chongchira Boonthongkaew, Wisitsak Phoksawat, Amonrat Jumnainsong, Chanvit Leelayuwat, Naruemon Leelayuwat
NUTRITION RESEARCH
(2020)
Article
Biotechnology & Applied Microbiology
T. Nitrosetein, M. Wongwattanakul, C. Chonanant, C. Leelayuwat, N. Charoensri, P. Jearanaikoon, A. Lulitanond, B. R. Wood, P. Tippayawat, P. Heraud
Summary: This study successfully differentiated 60 clinical isolates of Enterococcus faecium and Enterococcus faecalis using ATR-FT-IR spectroscopy and chemometric modelling. The support vector machine (SVM) was found to be the best classification model with the highest correlation to PCR results.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Immunology
Suwit Chaisri, Amonrat Jumnainsong, Amornrat Romphruk, Chanvit Leelayuwat
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Wisitsak Phoksawat, Amonrat Jumnainsong, Kanda Sornkayasit, Kanoungnit Srisak, Nantarat Komanasin, Chanvit Leelayuwat
MOLECULAR IMMUNOLOGY
(2020)
Article
Medicine, General & Internal
Wipaporn Wongfieng, Rungtiwa Nutalai, Amonrat Jumnainsong, Chanvit Leelayuwat