期刊
JOURNAL OF MICROBIOLOGY
卷 50, 期 4, 页码 665-672出版社
MICROBIOLOGICAL SOCIETY KOREA
DOI: 10.1007/s12275-012-2007-7
关键词
two-component signal transduction system; ArcA response regulator; target genes; Mannheimia succiniciproducens
类别
资金
- Genome-Based Integrated Bioprocess Project grant
- Intelligent Synthetic Biology Global Frontier Program of the National Research Foundation (NRF)
- Next-Generation BioGreen 21 Program grant from the Rural Development Administration, Republic of Korea
In this study, the putative target genes of the Arc two-component system of the rumen bacterium Mannheimia succiniciproducens were determined by analyzing the transcriptome of the ArcA overexpression strain and by the in silico scanning of the entire genome sequence with the position weight matrix of the ArcA binding sequence developed for Escherichia coli. The majority of 79 repressed genes were involved in energy metabolism and carbohydrate transport and metabolism, while the majority of 82 induced genes were involved in hypothetical or unknown functions. Our results suggest that the Arc system in M. succiniciproducens has a specific function that differs from that in E. coli.
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