Article
Chemistry, Multidisciplinary
Gwi Ju Jang, Ji Yeon Jeong, Junghoon Kang, Wonryeon Cho, Sang Yun Han
Summary: This study revealed a significant size dependence in the interactions between HDLs and PEG-AuNPs, with larger NPs showing higher affinity. However, the relative affinities of HDL and APOA1 exhibited opposite size dependences. It was concluded that the whole HDL complex interacts with spherical PEG-AuNPs in the initial stage of adsorption towards biomolecular coronas, with the varying curvatures of NPs playing a crucial role.
Article
Polymer Science
Ashesh Ghosh, Kenneth S. Schweizer
Summary: By combining concepts from polymer and glassy liquid physics, a new model has been constructed to describe the bond-breaking time scale of attractive sticker groups in associating copolymer liquids. The model suggests that the activated event is a two-step process involving the release of dynamic caging constraints and the attractive stickers surmounting a free-energy barrier. This model provides a consistent description for diverse polymer chemistries and architectures, while existing phenomenological models show qualitative failures.
Article
Chemistry, Multidisciplinary
Pamela C. Cai, Bo Su, Lei Zou, Matthew J. Webber, Sarah C. Heilshorn, Andrew J. Spakowitz
Summary: This study presents a molecular-level theory called the Brachiation model, which predicts the rheological behavior of dynamically associating polymers. By designing experimentally controllable parameters, we synthesized polymer networks with tunable physical properties and validated the reliability and effectiveness of the theoretical model through comparisons between experiments and theoretical predictions.
ACS CENTRAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Da Chen, Xiao Zhu, Jan Ilavsky, Tanya Whitmer, Emmanuel Hatzakis, Owen G. Jones, Osvaldo H. Campanella
Summary: The study revealed that green tea polyphenols decrease the elasticity and viscosity of pea protein gels, making the protein backbone less rigid. Additionally, gels weakened by polyphenols showed disrupted networks with large protein aggregates, and a reduction in hydrophobic interactions and hydrogen bonds among proteins.
Article
Physics, Multidisciplinary
Mohamad Menati, Stephen Williams, Behnam Rasoolian, Edward Thomas Jr, Uwe Konopka
Summary: Based on theoretical and computational investigations, the authors demonstrate that pattern formation and self-organization in low-pressure magnetized plasmas can be explained by Turing's activator-inhibitor model.
COMMUNICATIONS PHYSICS
(2023)
Article
Chemistry, Applied
Ozgenur Coskun, Lars Wiking, Saeed Rahimi Yazdi, Milena Corredig
Summary: The study obtained MPI and MCC using UF and MF, respectively, and assessed the effect of diafiltration on the colloidal dissociation of casein micelles. Comparison of serum phases with and without whey protein revealed significant differences in ionic strength and soluble proteins in the final concentrates, indicating potential indicators of ingredient quality and functionality.
FOOD HYDROCOLLOIDS
(2022)
Article
Plant Sciences
Ismail Dahmani, Kezhen Qin, Youjun Zhang, Alisdair R. Fernie
Summary: Metabolons are temporary structural-functional complexes of sequential enzymes in a metabolic pathway. In plants, only four substrate channels have been demonstrated. This study provides an overview of these four metabolons and discusses methodologies to enhance our knowledge of plant metabolons that assemble via different mechanisms, including liquid droplet phase separation and enzyme chemotaxis. Novel approaches based on subcellular-level mass spectral imaging, proteomics, and structural and computational biology are also proposed.
Article
Chemistry, Applied
Hui Xue, Tianfeng Han, Guowen Zhang, Xiaobo Hu, Ruiling Li, Huilan Liu, Rui Li, Yonggang Tu, Yan Zhao
Summary: Salted preserved eggs are made using a combination of NaOH, NaCl, and heat. This study investigated the effects of NaOH, NaCl, and heat on the properties of ovalbumin gel and found that they play a crucial role in the formation of a unique gel structure.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Physical
Zhihao Jin, Yajing Shen, Xianfu Chen, Minghui Qiu, Yiqun Fan
Summary: The introduction of Ce effectively inhibited the phase transformation of TiO2 and prevented cracks, resulting in excellent performance and anti-fouling properties for the Ce-doped TiO2 membrane in protein separation.
APPLIED SURFACE SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Nabila Yasmeen, Aneta Karpinska, Jakub Kalecki, Wlodzimierz Kutner, Karina Kwapiszewska, Piyush S. Sharma
Summary: Biocompatible polyacrylamide gel and core-shell nanoparticles were synthesized using a one-step electro-chemically initiated gelation. The core-shell nanoparticles exhibited superior support for complex 3D tissue structures.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Polymer Science
Ana M. Herrero, Claudia Ruiz-Capillas
Summary: The presence of chia oil significantly affects the technological and structural properties of SPI/EG, resulting in lower redness, higher lightness and yellowness, and increased texture and gel strength compared to SPI/G. Changes in the protein secondary structure, specifically higher alpha-helix and lower beta-sheet, turn, and unordered structures, were observed after chia oil incorporation, which correlated with the observed textural modifications.
Article
Materials Science, Ceramics
Svenja Pohl, Guido Kickelbick
Summary: Polysilsesquioxanes containing phenyl groups can form transparent and hard materials at room temperature, while softening when heated and irreversibly curing at higher temperatures. This property classifies them as melting gels. However, polysilsesquioxanes with alkyl groups have not been studied. In this study, a series of polyalkylsilsesquioxanes with varying alkyl chain lengths were synthesized and their structures and thermal reactions were investigated. The alkyl chain length was found to have an impact on the formation of highly crosslinked systems, low molecular weight oligosilsesquioxanes, and semicrystalline lamellar layers.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Jian Ding, Tong Xu, Zhihai Li, Xinyang Sun, Xiaoyi Jiang, Fengjiao Fan, Qu Yan, Fan Yang, Peng Li, Yong Fang
Summary: This study investigated the effects of different ratios of pea protein (PP) on the gel characteristics of rice protein (RP) and the formation mechanism of RP-PP binary mixed protein. The addition of PP improved the gel strength and hardness of the mixed protein gel, and scanning electron microscopy showed a homogeneous and denser gel network structure. The hydrophobic interactions between RP and PP played a key role in enhancing the interactions and gel strength of the mixed protein.
JOURNAL OF CEREAL SCIENCE
(2023)
Article
Chemistry, Applied
Ying Wu, Jingjing Wu, Xiaolin Meng, Lei Zhou, Wei Liu, Chengmei Liu, Sangeeta Prakash, Junzhen Zhong
Summary: In this study, fibrous and granular whey protein self-assembly (FWS and GWS) were induced from whey protein (WP) with a 6% protein concentration using a pH-temperature gradient. The gel formation mechanism and the potential of FWS and GWS as a delivery system for EGCG were investigated. FWS and GWS gels had denser microstructure and higher mechanical strength compared to native WP gel. They also exhibited higher water holding capacity and hardness. FWS and GWS had higher encapsulation efficiency of EGCG and a slow release effect during digestion. Therefore, FWS and GWS gels have potential applications in protein gel technology and as carriers for bioactive substances.
FOOD HYDROCOLLOIDS
(2023)
Article
Food Science & Technology
Cuicui Ma, Siqi Li, Yan Yin, Wenhan Xu, Tiantian Xue, Yutang Wang, Xuebo Liu, Fuguo Liu
Summary: An emulsion gel loaded with allicin was constructed using ultrasound treatment and transglutaminase induction, which effectively protected allicin. Ultrasonic pretreatment improved the physical properties of the emulsion gel, forming a denser homogeneous network structure.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Xiang Cao, Shannon C. Flagg, Xue Li, Naresh Chennamsetty, Gurusamy Balakrishnan, Tapan K. Das
ANALYTICAL CHEMISTRY
(2019)
Article
Medicine, Research & Experimental
Magfur E. Alam, Gregory V. Barnett, Thomas R. Slaney, Charles G. Starr, Tapan K. Das, Peter M. Tessier
MOLECULAR PHARMACEUTICS
(2019)
Article
Chemistry, Medicinal
Kaimeng Zhou, Xiang Cao, James Bautista, Zhi Chen, Neil Hershey, Richard Ludwig, Li Tao, Ming Zeng, Tapan K. Das
JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Review
Chemistry, Medicinal
Tapan K. Das, Linda O. Narhi, Alavattam Sreedhara, Tim Menzen, Christoph Grapentin, Danny K. Chou, Valentyn Antochshuk, Vasco Filipe
JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Chemistry, Medicinal
Mario Hubert, Dennis T. Yang, Stanley C. Kwok, Anacelia Rios, Tapan K. Das, Ankit Patel, Klaus Wuchner, Valentyn Antochshuk, Friederike Junge, George M. Bou-Assaf, Shawn Cao, Miguel Saggu, Luis Montrond, Nataliya Afonina, Parag Kolhe, Vakhtang Loladze, Linda Narhi
JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Chemistry, Medicinal
Magfur E. Alam, Thomas R. Slaney, Lina Wu, Tapan K. Das, Sambit Kar, Gregory V. Barnett, Anthony Leone, Peter M. Tessier
JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Chemistry, Analytical
Zhi Chen, Ming Zeng, Sung-Joo Park, Gurusamy Balakrishnan, Kaimeng Zhou, Duohai Pan, Tapan K. Das
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2020)
Article
Chemistry, Medicinal
Sudhakar Voruganti, Jiahui Xu, Xue Li, Gurusamy Balakrishnan, Surinder M. Singh, Sambit R. Kar, Tapan K. Das
Summary: N-linked glycosylation is an important post-translational modification on mAbs, playing crucial roles in antibody structure, stability, and function. Fc glycans consist of various sugars such as galactose, mannose, and sialic acid, with the role of galactose in antibody effector functions being poorly understood. There is a widespread interest in understanding the role of galactose, as a major constituent of antibody glycans, in the antibody research community.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Medicinal
Tapan K. Das, Alavattam Sreedhara, James D. Colandene, Danny K. Chou, Vasco Filipe, Christoph Grapentin, Jim Searles, Twinkle R. Christian, Linda O. Narhi, Wim Jiskoot
Summary: Injectable protein-based medicinal products must be produced using sterile manufacturing processes to ensure product safety. The manufacturing process should identify critical quality attributes and assess potential risks to ensure product quality.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Joshua S. Katz, Danny K. Chou, Twinkle R. Christian, Tapan K. Das, Mayank Patel, Shubhadra N. Singh, Yi Wen
Summary: Biologics need to be properly formulated to withstand various destabilizing conditions they may encounter during manufacturing, transportation, storage, and use. Surfactants, such as Polysorbate 80 and Polysorbate 20, play a critical role in stabilizing protein-based biologics. However, challenges associated with traditional surfactants have prompted the development of novel surfactants. This review provides an in-depth discussion on surfactants, including their mechanisms of action, challenges, and emerging technologies for novel surfactant development.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Biographical-Item
Chemistry, Medicinal
Daan J. A. Crommelin, Linda O. Narhi, Tapan K. Das
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Kurt D. Benkstein, Gurusamy Balakrishnan, Ashwinkumar Bhirde, Pascal Chalus, Tapan K. Das, Ngoc Do, David L. Duewer, Nazar Filonov, Fook Chiong Cheong, Patrick Garidel, Nicole S. Gill, Adam D. Grabarek, David G. Grier, Judith Hadley, Andrew D. Hollingsworth, Wesley W. Howard, Maciej Jarzebski, Wim Jiskoot, Sambit R. Kar, Vikram Kestens, Harshit Khasa, Yoen Joo Kim, Atanas Koulov, Anja Matter, Laura A. Philips, Christine Probst, Yannic Ramaye, Theodore W. Randolph, Dean C. Ripple, Stefan Romeijn, Miguel Saggu, Franziska Schleinzer, Jared R. Snell, Jan Kuba Tatarkiewicz, Heather Anne Wright, Dennis T. Yang
Summary: This paper presents a study on the measurement variability of sub-micrometer polydisperse protein aggregates and particles in biotherapeutics. It includes an interlaboratory comparison involving 20 laboratories and different particle-counting instruments. The results show high variability between datasets from different laboratories and provide guidance for instrument performance assessment and the development of polydisperse reference materials.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Linda O. Narhi, Danny K. Chou, Twinkle R. Christian, Scott Gibson, Bharat Jagannathan, Wim Jiskoot, Susan Jordan, Alavattam Sreedhara, Lloyd Waxman, Tapan K. Das
Summary: Protein-based biologic drugs face various stress factors during manufacturing, transportation, and handling processes, which may have negative impacts on drug product quality. This article discusses the risks of primary packaging contamination, substance leachables, protein degradation, and the influence of different packaging containers on transportation and handling stresses. It proposes mitigations and control strategies to ensure drug product quality and calls for further research on postproduction transportation and handling practices.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Tapan K. Das, Danny K. Chou, Wim Jiskoot, Paolo Arosio
Summary: Protein aggregation is a challenging phenomenon in the field of biologics research and development. Nucleation is the core step that initiates protein aggregation. Understanding nucleation is crucial for avoiding undesired protein aggregation. This review article discusses the latest progress in protein aggregation research, including nucleation events, identification of protein aggregation sources, and development of analytical tools. It also highlights significant gaps in the analysis and understanding of nucleation in non-native protein aggregation.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Chemistry, Medicinal
Marie R. G. Kopp, Fulvio Grigolato, Dominik Zurcher, Tapan K. Das, Danny Chou, Klaus Wuchner, Paolo Arosio
Summary: Protein stability against aggregation is a major concern in biopharmaceutical production. Interactions between proteins and interfaces, such as air-water and silicone oil-water interfaces, as well as materials from processing units, storage containers, and delivery devices, play a significant role in protein aggregation. However, the key determinants and analytical methods for monitoring and predicting protein instability at these interfaces remain difficult to identify. This review discusses the mechanisms, potential harmful materials, mitigation strategies, and current methods for studying surface-induced protein instability, aiming to aid early-stage screening and formulation development of biologics.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Engineering, Chemical
Jiawei Hou, Shixuan Guo, Nigel Graham, Wenzheng Yu, Kening Sun, Ting Liu
Summary: A novel 2D composite membrane based on r-HGO and MXene materials was developed, demonstrating exceptional performance for water treatment in terms of permeability, pollutant rejection, and physical stability. The optimization of preparation conditions and material proportions can result in high water flux and efficient removal of pollutants.
JOURNAL OF MEMBRANE SCIENCE
(2024)
Retraction
Engineering, Chemical
Chang Liu, Jinghong Liu, Liang Zhu, Shanfu Tang, Huixin Xiong
JOURNAL OF MEMBRANE SCIENCE
(2024)
Article
Engineering, Chemical
Rui Gao, Caihong Liu, Andreia F. Faria, Qiang He, Chun Yang, Jun Ma
Summary: A novel copolymer architecture has been developed to address biofouling concerns in thin-film composite (TFC) membranes by integrating anti-fouling, bactericidal, and fouling-release functions. The multifunctional membrane demonstrates promising anti-adhesive properties, self-cleaning ability, and high flux recovery rate.
JOURNAL OF MEMBRANE SCIENCE
(2024)
Article
Engineering, Chemical
Alexander T. Bridge, Noah P. Wamble, Matthew S. Santoso, Joan F. Brennecke, Benny D. Freeman
Summary: This study demonstrates the reproducible preparation of high-flux defect-free asymmetric gas separation membranes using Cyrene(TM) as a majority dope formulation component. By adjusting the volume ratios of Cyrene(TM) and THF, as well as the concentrations of Matrimid(R) and the dry step time, optimal membrane performance is achieved.
JOURNAL OF MEMBRANE SCIENCE
(2024)
Article
Engineering, Chemical
Alessandra Imbrogno, Han Ya Lin, Babak Minofar, Andrea Iris Schaefer
Summary: In this study, a composite nanofiber membrane containing cross-linked beta-cyclodextrin-epichlorohydrin was prepared and evaluated for the removal of steroid hormones. The results showed that the membrane had high adsorption capacity and the ability to form a specific inclusion complex interaction with the hormones, indicating its potential application in hormone removal.
JOURNAL OF MEMBRANE SCIENCE
(2024)
Article
Engineering, Chemical
Bora Shin, Jaewon Shin, Yanuar Chandra Wirasembada, Ki Young Park, Jinwoo Cho
Summary: This study develops a mathematical model to estimate the initial flux of volatile fatty acids in the direct contact membrane distillation process. It identifies the parameters affecting the flux and their relationship with pH.
JOURNAL OF MEMBRANE SCIENCE
(2024)
Article
Engineering, Chemical
Yi-Jui Yeh, Jr Rong Liou, Wei Lin, Kuo-Lun Tung, Wei-Hung Chiang
Summary: This study demonstrates an effective plasma engineering method to create nitrogen-doped graphene quantum dot (NGQD)-inorganic nanocomposites for tunable molecular separation. The composite materials show high separation efficiency and controllable nanopore structures, making them potentially valuable for various applications.
JOURNAL OF MEMBRANE SCIENCE
(2024)
Article
Engineering, Chemical
Horacio Lopez-Marques, Kristofer L. Gleason, Manuel Aguilar-Vega, Rita Sulub-Sulub, J. Ehren Eichler, Hyeonji Oh, C. Buddie Mullins, Benny D. Freeman, Manish Kumar
Summary: In this study, water transport properties in Carbon Molecular Sieve (CMS) membranes were investigated. It was found that membranes synthesized at different pyrolysis temperatures exhibited varying water permeabilities. Compared to other polymeric materials, CMS membranes showed high water permeability, indicating potential for dehydration applications.
JOURNAL OF MEMBRANE SCIENCE
(2024)
Article
Engineering, Chemical
Dmitry A. Alentiev, Roman Yu. Nikiforov, Marina A. Rudakova, Danil P. Zarezin, Maxim A. Topchiy, Andrey F. Asachenko, Nikolay A. Belov, Maxim Bermeshev
Summary: A series of new norbornene-type monomers containing linear and branched substituents were synthesized, and robust thin membranes were prepared by vinyl-addition polymerization. Gas separation performance for the synthesized polymers was evaluated, and the structure of substituent side chains was found to significantly affect gas permeability and CO2 facilitated transport.
JOURNAL OF MEMBRANE SCIENCE
(2024)
Article
Engineering, Chemical
Lei Yan, Qi Zhang, Ze Zhang, Gui-Jie Li, Yi Jin, Xin-Lin Zhang, Yan-Yun Sun
Summary: In this study, a continuous, stable and fast ion transport channel was established through in-situ guided cross-linking of zinc alginate hydrogels on a porous membrane, overcoming the negative pore effect and effectively inhibiting the dendrite growth of zinc anodes and interfacial side reactions.
JOURNAL OF MEMBRANE SCIENCE
(2024)
Article
Engineering, Chemical
Yuqing Zhang, Ailing Zhang, Huiyang He, Yuting Fan, Yongjiang Li, Song Wang, Sanxi Li
Summary: The Langmuir-Blodgett self-assembly process is used to create an ordered SPEEK membrane, which enhances the proton conductivity by three times compared to conventional solution casting method.
JOURNAL OF MEMBRANE SCIENCE
(2024)
Article
Engineering, Chemical
Hasan Ismaeel, David Gibson, Eleonora Ricci, Maria Grazia De Angelis
Summary: In this study, a machine learning-based group contribution method (ML-GC) was developed to predict pure polymer parameters and successfully applied to predict gas solubility and gas solubility isotherms in glassy polymeric membranes. The model showed satisfactory performance on a small dataset, but has the potential to provide more accurate predictions for a wider range of polymers as more data becomes available.
JOURNAL OF MEMBRANE SCIENCE
(2024)
Article
Engineering, Chemical
Yi Ji, Yu Sun, Huilin Li, Qiang Fu, Yan Zhang
Summary: Previous studies have shown that vibration- or rotation-based techniques can effectively mitigate fouling during membrane filtration. However, it is difficult to incorporate these techniques with spiral wound modules (SWMs) widely used in water and wastewater treatment. This study developed a prototype membrane system to accommodate angular vibrations with a modified SWM, and experimental results showed that applying angular vibrations can effectively control algal fouling in an SWM with lower energy consumption compared to traditional methods.
JOURNAL OF MEMBRANE SCIENCE
(2024)
Article
Engineering, Chemical
Lakshmeesha Upadhayaya, Abaynesh Yihdego Gebreyohannes, Muhammad Wakil Shahzad, Usman T. Syed, Sandra L. Aristizabal, Radoslaw Gorecki, Suzana P. Nunes
Summary: Increasing temperatures worldwide pose a significant health risk, exacerbated by high humidity. Conventional air conditioners contribute heavily to carbon dioxide emissions, with dehumidification being a major factor. Membrane-based dehumidification system offers energy efficiency and non-toxic water vapor removal. This study demonstrates a membrane dehumidification system with polymeric hollow fibers coated with a green polyphenol coating, showing remarkable water vapor transport rate and selectivity. Long-term testing reveals minimal decline in vapor transport and a 4-5 times higher coefficient of performance (COP) compared to conventional dehumidifiers, making it a highly competitive, energy-saving device with reduced emissions and a smaller footprint.
JOURNAL OF MEMBRANE SCIENCE
(2024)
Article
Engineering, Chemical
Zhengzhong Zhou, Xue Zhu, Yi Yuan, Shaoqiang Wang, Xiaoshan Meng, Taoli Huhe, Qian Wang
Summary: In this study, lignin, a biomass material, was chemically modified and utilized in the interfacial polymerization process to improve the performance of nanofiltration membranes. The modified membranes showed enhanced hydrophilicity and anti-fouling properties, and the optimization of membrane pore size increased permeability. The study also demonstrated the potential application of the membranes in biogas slurry valorization.
JOURNAL OF MEMBRANE SCIENCE
(2024)