Article
Physiology
Aya Yamada, Keigo Yoshizaki, Masaki Ishikawa, Kan Saito, Yuta Chiba, Emiko Fukumoto, Ryoko Hino, Seira Hoshikawa, Mitsuki Chiba, Takashi Nakamura, Tsutomu Iwamoto, Satoshi Fukumoto
Summary: Connexin 43 (Cx43) is an integral membrane protein that plays a crucial role in tooth development, regulating intercellular communication through gap junction activity by modulating TGF-beta 1-mediated ERK signaling and enamel formation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Mariano Cruz Del Puerto, Maria Laura Rojas, Ana Cristina Racca, Lucille Tihomirova Kourdova, Andrea Lis Miranda, Graciela Panzetta-Dutari, Susana Genti-Raimondi, Jesica Belen Flores-Martin
Summary: StarD7 is involved in cell migration through an ERK1/2/Cx43 dependent mechanism, independent of its function in mitochondria. The migratory capacity of cells is restored by reestablishing Cx43 level, while p-ERK1/2 expression remains low.
Article
Pharmacology & Pharmacy
Siqi Zhang, Yixin Fan, Binbin Zheng, Yu Wang, Chen Miao, Yue Su, Kun Li, Yan E, Xueli Wang, Xueming He, Xuefeng Wu, Chenjie Xu, Yulin Tang, Wen-Tao Liu, Xiangqing Kong, Liang Hu
Summary: This study demonstrates that bilirubin has a potential protective effect against doxorubicin-induced cardiotoxicity. By activating the AMPK-Axl-SOCS3 signaling axis, bilirubin upregulates gap junction function, thereby attenuating doxorubicin-induced arrhythmia and myocardial damage.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Talita A. M. Vrechi, Anderson H. F. F. Leao, Ingrid B. M. Morais, Vanessa C. Abilio, Antonio W. Zuardi, Jaime Eduardo C. Hallak, Jose Alexandre Crippa, Claudia Bincoletto, Rodrigo P. Ureshino, Soraya S. Smaili, Gustavo J. S. Pereira
Summary: CBD activates autophagy through ERK1/2 activation and AKT suppression, dependent on ULK1 but independent of mTORC1, suggesting a potential non-canonical pathway and highlighting CBD as a potential therapeutic target for neurodegenerative disorders.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Ai Li, Tianyuan Zhang, Ting Huang, Ruyi Lin, Jiafu Mu, Yuanqin Su, Hao Sun, Xinchi Jiang, Honghui Wu, Donghang Xu, Hongcui Cao, Xiaoyi Sun, Daishun Ling, Jianqing Gao
Summary: In this study, gene transfection using magnetosome-like ferrimagnetic iron oxide nanochains (MFIONs) achieved high expression of HSV-tk in MSCs and promoted gap junction intercellular communication (GJIC) between MSCs and tumor cells, leading to significantly inhibited growth of glioma through an improved bystander effect. The results suggest that iron oxide nanoparticles have the potential to enhance suicide gene expression levels in MSCs and improve the sensitivity of glioma cells to HSV-tk/GCV suicide gene therapy.
Review
Chemistry, Medicinal
Yagya P. Subedi, Guillermo A. Altenberg, Cheng-Wei T. Chang
Summary: Gap-junction channels formed by connexin hemichannels are crucial for intercellular communication, but abnormal activity can lead to diseases. Amphiphilic kanamycins, especially towards connexin 43 inhibition, show promising potential with low cytotoxicity.
FUTURE MEDICINAL CHEMISTRY
(2021)
Article
Reproductive Biology
Monica De los Reyes, Jaime Palomino, Allison Villagra, George Ramirez, Oscar A. Peralta, Victor H. Parraguez, Karla Aspee
Summary: This study aimed to evaluate the effect of progesterone on meiotic development related to the gene expression of connexin 37 and connexin 43 in canine cumulus oocyte complexes. The results showed that progesterone increased meiotic development in canine oocytes but had no effect on the gene expression of connexin 37 and connexin 43.
Article
Cardiac & Cardiovascular Systems
Li Zheng, Gaelle Spagnol, Devashri R. Gandhi, Kanika Sharma, Vikas Kumar, Kaushik P. Patel, Paul L. Sorgen
Summary: Inhibition of Pyk2 improves cardiac function and reduces myocardial infarct size in a rat model of heart failure, likely by maintaining Cx43 localization and communication between cardiomyocytes. This finding is significant for heart failure treatment and suggests Pyk2 as a potential therapeutic target.
CIRCULATION-HEART FAILURE
(2023)
Article
Dermatology
Amy L. Harding, Helen E. Colley, Inmaculada Barragan Vazquez, Simon Danby, Md Zobaer Hasan, Hirofumi Nakanishi, Tetsuo Furuno, Craig Murdoch
Summary: Skin irritancy is a significant problem that affects millions of people worldwide. New testing methods using human skin equivalents have found evidence of specific activation of c-Src kinase in response to chemical irritants, suggesting the development of rapid screening methods for potential irritants.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Anesthesiology
Attila Keresztes, Keith Olson, Paul Nguyen, Marissa A. Lopez-Pier, Ryan Hecksel, Natalie K. Barker, Zekun Liu, Victor Hruby, John Konhilas, Paul R. Langlais, John M. Streicher
Summary: This study reveals a new function of opioid receptors as a negative feedback brake on opioid-induced analgesia. By using a selective antagonist for the mu and delta opioid receptors (MDOR), the researchers found that the antagonist could enhance the analgesic effect of oxymorphone in mice, suggesting a role for MDOR in regulating pain. Additionally, the study found that the enhancement effect was selective to MDOR and occurred through the repression of Src and CaMKII signal transduction. These findings suggest that MDOR antagonism could be a potential approach to improve clinical opioid therapy.
Article
Biochemistry & Molecular Biology
Miyuki Tauchi, Kensuke Oshita, Katharina Urschel, Roman Furtmair, Constanze Kuehn, Florian M. Stumpfe, Balazs Botos, Stephan Achenbach, Barbara Dietel
Summary: This study investigated the activation of endothelial cells under non-uniform shear stress, focusing on stress-regulated mitogen-activated protein kinases (MAPKs) and downstream signaling, as well as their relation to gap junction proteins, Connexins (Cxs). The results showed that JNK1/2 and ERK were activated by non-uniform shear stress, and inhibiting JNK1/2 reduced THP-1 cell adhesion under non-uniform shear stress. In addition, the expression of Cx43 in human carotid plaques was found to be associated with plaque vulnerability, suggesting its contribution to plaque progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Claudia M. Lucero, Lucas Marambio-Ruiz, Javiera Balmazabal, Juan Prieto-Villalobos, Marcelo Leon, Paola Fernandez, Juan A. Orellana, Victoria Velarde, Juan C. Saez, Gonzalo Gomez
Summary: This study found that the activation of Cx43 hemichannels and inhibition of cell-cell coupling during inflammation may contribute to oxidative stress and damage of mesangial cells through the RhoA/ROCK pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ishika Basu, Hanjun Li, Andrew J. Trease, Paul L. Sorgen
Summary: T and B cell receptor signaling activates Akt, MAPKs, PKC, intracellular Ca2+, and calmodulin. This process involves Src and the phosphorylation of Cx43 residues Y247, Y265, and Y313 by BTK and ITK. Overexpression of BTK or ITK leads to increased Cx43 phosphorylation and decreased gap junction communication in HEK-293T cells. Activation of B cell receptor or T cell receptor enhances BTK and ITK activity, resulting in decreased Cx43 phosphorylation and altered gap junction function.
Article
Medicine, General & Internal
Yumeng Shi, Xinbo Li, Jin Yang
Summary: This study found that mechanical stretch increases Cx43 protein expression in human umbilical vein endothelial cells, mainly through the TGF beta1 receptor signaling pathway and involving the actin and microtubule cytoskeletal network.
Article
Biochemistry & Molecular Biology
Josip Lesko, Pejana Rastovic, Josip Miskovic, Violeta Soljic, Vlatka Pastar, Zdenka Zovko, Natalija Filipovic, Yu Katsuyama, Mirna Saraga-Babic, Katarina Vukojevic
Summary: By investigating the deficiency of DAB1-protein in the inner-ear development of yotari, we found that most connexins were significantly decreased in yotari, compared to wild-type mice and humans. Additionally, the expression of pannexin PANX1 was also significantly lower in yotari, except at certain developmental stages. These results emphasize the importance of connexins in the development of vestibular and cochlear functions and provide potential therapeutic targets for inner-ear impairments.
Article
Cell Biology
Srikanth R. Polusani, Edward A. Kalmykov, Anjana Chandrasekhar, Shoshanna N. Zucker, Bruce J. Nicholson
JOURNAL OF CELL SCIENCE
(2016)
Article
Clinical Neurology
Joanne O. Davidson, Colin R. Green, Louise F. B. Nicholson, Simon J. O'Carroll, Mhoyra Fraser, Laura Bennet, Alistair Jan Gunn
ANNALS OF NEUROLOGY
(2012)
Article
Hematology
Daniel J. Chaston, Brett K. Baillie, T. Hilton Grayson, Raphael J. Courjaret, Jillian M. Heisler, Katherine A. Lau, Khaled Machaca, Bruce J. Nicholson, Anthony Ashton, Klaus I. Matthaei, Caryl E. Hill
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2013)
Review
Biochemistry & Molecular Biology
Ji Xu, Bruce J. Nicholson
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2013)
Article
Cell Biology
Jialu Liu, Ji Xu, Sumin Gu, Bruce J. Nicholson, Jean X. Jiang
JOURNAL OF CELL SCIENCE
(2011)
Article
Biochemistry & Molecular Biology
Atsunori Oshima, Kazutoshi Tani, Masoud M. Toloue, Yoko Hiroaki, Amy Smock, Sayaka Inukai, Angela Cone, Bruce J. Nicholson, Gina E. Sosinsky, Yoshinori Fujiyoshi
JOURNAL OF MOLECULAR BIOLOGY
(2011)
Article
Multidisciplinary Sciences
Rugmani Padmanabhan Iyer, Sumin Gu, Bruce J. Nicholson, Jean X. Jiang
Article
Multidisciplinary Sciences
Qian Ren, Manuel A. Riquelme, Ji Xu, Xiang Yan, Bruce J. Nicholson, Sumin Gu, Jean X. Jiang
Article
Multidisciplinary Sciences
Anjana Chandrasekhar, Edward A. Kalmykov, Srikanth R. Polusani, Sandra A. Mathis, Shoshanna N. Zucker, Bruce J. Nicholson
Article
Immunology
Srikanth Manam, Bruce J. Nicholson, Ashlesh K. Murthy
PATHOGENS AND DISEASE
(2013)
Meeting Abstract
Biochemistry & Molecular Biology
Bruce Nicholson, Edward Kalmykov, Anjana Chandrasekhar, Srikanth Polusani, Shoshana Zucker
Meeting Abstract
Peripheral Vascular Disease
S. K. Morton, L. Howitt, J. Heisler, B. J. Nicholson, A. W. Ashton, K. Mathhaei, C. E. Hill
Article
Peripheral Vascular Disease
Susan K. Morton, Daniel J. Chaston, Lauren Howitt, Jillian Heisler, Bruce J. Nicholson, Stephen Fairweather, Stefan Broeer, Anthony W. Ashton, Klaus I. Matthaei, Caryl E. Hill
Meeting Abstract
Biochemistry & Molecular Biology
Daniel J. Chaston, Brett K. Baillie, T. Hilton Grayson, Raphael J. Courjaret, Jillian M. Heisler, Katherine A. Lau, Khaled Machaca, Bruce J. Nicholson, Anthony Ashton, Klaus I. Matthaei, Caryl E. Hill