Article
Agriculture, Dairy & Animal Science
Nikolett Palkovicsne Pezsa, Dora Kovacs, Fanni Somogyi, Zita Karancsi, Alma Virag Moritz, Akos Jerzsele, Bence Racz, Orsolya Farkas
Summary: This study established a co-culture model to simulate gastrointestinal infection and evaluated the beneficial effects of L. rhamnosus. The results showed that L. rhamnosus can improve barrier function, reduce inflammation, and inhibit adhesion.
Article
Biology
Lucas Harrison, Shaohua Zhao, Cong Li, Patrick F. McDermott, Gregory H. Tyson, Errol Strain
Summary: Lociq is a computational method that generates typing schema to aid investigations into the origin, evolution, and epidemiology of multidrug resistant plasmids. It classifies plasmids by variations in the sequence and arrangement of core plasmid genetic elements, providing a way to track and characterize the origin, evolution, and epidemiology of these plasmids.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lingyu Zhu, Zitao Guo, Ji Zhang, Yuliang Yang, Chunyu Liu, Liang Zhang, Zhenghua Gu, Youran Li, Zhongyang Ding, Guiyang Shi
Summary: In this study, human arresten and canstatin were successfully recombinantly expressed in Escherichia coli, and their anti-angiogenesis effects on human umbilical vein endothelial cells (HUVECs) were demonstrated. The results showed that arresten and canstatin could inhibit HUVECs proliferation, migration, and tube formation, as well as downregulate the expression of vascular endothelial growth factor (VEGF) and the phosphorylation levels of PI3K and Akt, suggesting the inhibition of the PI3K/Akt signaling pathway. These findings have important implications for the soluble recombinant expression of human arresten and canstatin, and for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Rachele Francese, Manuela Donalisio, Massimo Ritta, Federica Capitani, Veronica Mantovani, Francesca Maccari, Paola Tonetto, Guido E. Moro, Enrico Bertino, Nicola Volpi, David Lembo
Summary: HM-GAGs have significant anti-HCMV and anti-RSV activity and alter virus binding to the cell. The contribution of individual HM-GAGs depends on their structure, rather than a simple charge interaction between the virus and sulfate groups. The antiviral activity of HM-GAGs does not change after thermal treatment.
PEDIATRIC RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Jonathan J. Lopez-Islas, Estela T. Mendez-Olvera, Daniel Martinez-Gomez, Andres M. Lopez-Perez, Libertad Orozco, Gerardo Suzan, Carlos Eslava
Summary: Emerging diseases pose a constant challenge in public health, and wild carnivores can be carriers of atypical strains of pathogenic microorganisms, highlighting the importance of natural environments in studying emerging diseases.
Article
Nutrition & Dietetics
Nikolett Palkovicsne Pezsa, Dora Kovacs, Peter Galfi, Bence Racz, Orsolya Farkas
Summary: Intestinal diseases caused by Salmonella spp. and Escherichia coli are a major economic concern in the farming industry. The use of antibiotics to control these diseases has led to the development of antibiotic resistance. This study investigates the potential of Enterococcus faecium as an alternative to antibiotics for maintaining gastrointestinal health. The results show that Enterococcus faecium can reduce oxidative stress, improve intestinal permeability, and inhibit the adhesion of Salmonella Typhimurium and Escherichia coli.
Article
Multidisciplinary Sciences
Athanasios Nikolaou, Monica Felipe-Sotelo, Robert Dorey, Jorge Gutierrez-Merino, Daniela Carta
Summary: This study investigates the controlled release of antibacterial ions in phosphate-based coacervates (PC) gels. The results show that the gel can release antibacterial ions over time and significantly reduce bacterial growth. Biocompatibility studies also demonstrate an increase in cell viability when the gel is dissolved.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Analytical
Michailia Angelopoulou, Panagiota Petrou, Konstantinos Misiakos, Ioannis Raptis, Sotirios Kakabakos
Summary: In this study, a miniaturized immunosensor based on broadband Mach-Zehnder Interferometry was developed for the simultaneous determination of S. typhimurium and E. coli O157:H7 in drinking water and milk. The assay was fast, accurate, sensitive, and reproducible, making it suitable for on-site bacteria determination in these samples.
Article
Food Science & Technology
Joshua B. Gurtler, Kristen E. Gibson
Summary: This article presents recent scientific research on irrigation water contamination of fresh produce and the corresponding treatments. It also highlights multidisciplinary studies on the risks associated with bacterial pathogen contamination of produce through irrigation water and various approaches to mitigate these risks. Additionally, proposed changes to the Microbial Water Quality Profile requirement outlined in the Food Safety Modernization Act, Produce Safety Rule, are discussed.
CURRENT OPINION IN FOOD SCIENCE
(2022)
Article
Multidisciplinary Sciences
Olivia Dwijayanti Wiguna, Diana Elizabeth Waturangi, Yogiara
Summary: This study found that DW-EC bacteriophage isolated from Indonesian traditional food has inhibitory and destructive effects on the biofilms of pathogenic E. coli, and its activity is significantly higher than that against B. cereus. This indicates that DW-EC bacteriophage has the potential to be used as an anti-biofilm candidate for polystyrene and stainless steel equipment in the food industry.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Katherine Blackshaw, Jiadai Wu, Peter Valtchev, Edwin Lau, Richard B. Banati, Fariba Dehghani, Aaron Schindeler
Summary: The study assesses a hybrid method of freeze-drying followed by low-dose gamma-irradiation for nonthermal pasteurisation of donor human milk, finding that it can efficiently preserve antimicrobial properties. Compared to Holder pasteurisation, this method shows excellent reduction of bacterial inoculants and simplifies storage and transportation processes.
Article
Multidisciplinary Sciences
Shawky M. Aboelhadid, Shaymaa Hashem, El-Sayed Abdel-Kafy, Lilian N. Mahrous, Eman M. Farghly, Abdel-Azeem S. Abdel-Baki, Saleh Al-Quraishy, Asmaa A. Kamel
Summary: The study found that prebiotic supplementation can significantly reduce the prevalence of Escherichia coli and Salmonella in the intestines of rabbits infected with coccidia. Additionally, the results showed that prebiotic supplementation can decrease oocyst count in the rabbits.
Article
Immunology
Minghui Cui, Guangfu Tang, Fang Yan, Shunshan Wang, Xi Wang, Junhu Yao, Xiurong Xu
Summary: This study evaluated the protective effect of heat-inactivated Escherichia coli (IEC) on the intestines of weaned rats challenged with Salmonella Typhimurium (S.Typhimurium). The results showed that oral administration of IEC during suckling alleviated S.Typhimurium-induced injury in ileal morphology by increasing the levels of tight junction proteins and secreted proteins in the intestinal mucosa. Furthermore, pre-stimulation with IEC enhanced immune responses and decreased certain bacterial abundances after intestinal infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Karin Hassenberg, Ulrike Praeger, Werner B. Herppich
Summary: Chlorine dioxide (ClO2) as a disinfectant in vegetable processing effectively reduces bacterial loads and improves product quality and consumer safety. Although the disinfection efficacy is limited for Listeria monocytogenes, it helps to prevent cross-contamination at high organic loads.
Article
Ecology
Ayush Pathak, Daniel C. Angst, Ricardo Leon-Sampedro, Alex R. Hall
Summary: Some bacterial resistance mechanisms can degrade antibiotics, potentially protecting neighboring susceptible cells. However, the effects of such mechanisms on bacterial communities of more than two species are not well understood. By conducting experiments on multispecies communities, we found that resistance in one species reduced antibiotic inhibition of other species, but the extent of benefit varied among species.
Article
Mathematics, Applied
Alessandra Coscia
Summary: In this work, we establish sharp regularity results for minimizers of a specific functional, showing their belonging to class C-0, C-alpha and C-1, C-alpha under suitable conditions on the continuity of the involved functions.
JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS
(2021)
Article
Pediatrics
Alessandra Coscia, Giovanni Boscarino, Maria Di Chiara, Francesca Faccioli, Roberto Pedicino, Elisa Onesta, Antonella Giancotti, Violante Di Donato, Benedetta Ronchi, Francesca Zantonelli, Alessia Russo, Chiara Mezzapiastra, Gianluca Terrin
Summary: The study demonstrates the effectiveness of a natural dermo-protective powder containing extract of Arnica montana in reducing cord detachment time, improving parents' stress levels, and reducing the risk of complications in newborns.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Obstetrics & Gynecology
Laura Lucaccioni, Alessandra Boncompagni, Marisa Pugliese, Giovanna Talucci, Elisa Della Casa, Natascia Bertoncelli, Alessandra Coscia, Luca Bedetti, Alberto Berardi, Lorenzo Iughetti, Fabrizio Ferrari
Summary: Despite significant catch-up growth at 3 months, some late FGR infants still had auxological parameters below the 3rd percentile, and a lower percentage of late FGR infants showed fidgety movements compared to AGA controls. The cranial circumference at birth was a predictive factor for fidgety movements. At 2 years of age, significant differences in neurodevelopmental outcomes were observed between late FGR and AGA infants.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Nursing
Andrea Civra, Rachele Francese, Manuela Donalisio, Paola Tonetto, Alessandra Coscia, Stefano Sottemano, Raffaella Balestrini, Antonella Faccio, Laura Cavallarin, Guido E. Moro, Enrico Bertino, David Lembo
Summary: The study found significant antiviral activity of human colostrum against rotavirus and respiratory syncytial virus, with extracellular vesicles interfering with early steps of viral replication. This contributes to understanding novel mechanisms of human milk as a protective and therapeutic agent in preterm infants.
JOURNAL OF HUMAN LACTATION
(2021)
Article
Biology
Valeria Bellisario, Enrico Cocchi, Roberta Tassinari, Giulia Squillacioti, Tiziana Musso, Stefano Sottemano, Michael Zorzi, Paola Dalmasso, Alessandra Coscia, Claudio Medana, Roberto Bono
Summary: The study aimed to evaluate the impact of bisphenol (BP) exposure during pregnancy and neonatal life. Results showed no significant correlations between maternal and neonatal BP levels, but positive correlations were found between pacifier use and BP S concentrations in newborns. Additionally, a significant correlation was found between oral glucose administration and free BPA levels. The study emphasized the role of lifestyle, hospital procedures, and neonatal devices in BP exposure and called for further research on the effects of various BP forms on human health and development.
Review
Obstetrics & Gynecology
Chiara Peila, Enrico Bertino, Francesco Cresi, Alessandra Coscia
Summary: Current studies on the impact of preeclampsia on breast milk composition are limited, with existing results suggesting that preeclampsia may alter the composition of breast milk.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Immunology
Michele Pinon, Laura Giugliano, Emanuele Nicastro, Omar Kakaa, Alessandra Coscia, Caterina Carbonara, Lorenzo D'Antiga, Pier Luigi Calvo
Summary: A retrospective analysis in Italy found that some newborns received HBV vaccination within 12 hours of birth, but two cases of vertical transmission still occurred despite timely immunoprophylaxis. It is recommended to give immunoprophylaxis to babies born to HBsAg positive mothers within 12 hours to prevent perinatal HBV infection, and further implementation of policies aimed at eliminating viral hepatitis is needed to achieve the WHO 2030 goal.
Article
Food Science & Technology
Costanza Pira, Gianfranco Trapani, Maurizio Fadda, Concetta Finocchiaro, Enrico Bertino, Alessandra Coscia, Catalina Ciocan, Magdalena Cuciureanu, Simona-Codruta Heghes, Maria Vranceanu, Doina Miere, Lorena Filip
Summary: The study found that Romanian children born in Italy or migrated to Italy have better adherence to the Mediterranean diet compared to those who stayed in Romania, but they are more exposed to a westernized diet and engage in less physical activity.
Article
Chemistry, Applied
Marzia Giribaldi, Stefano Nebbia, Valerie Briard-Bion, Julien Jardin, Chiara Peila, Alessandra Coscia, Didier Dupont, Laura Cavallarin, Amelie Deglaire
Summary: The study found that High Temperature-Short Time pasteurization and Holder pasteurization have different effects on peptide release in human milk during simulated preterm infant gastrointestinal digestion. The peptidomic profile of human milk differed according to the pasteurization type, with HTST pasteurization showing a greater similarity to raw milk.
Article
Obstetrics & Gynecology
Chiara Peila, Mariangela Longini, Anna Laura Toni, Stefano Sottemano, Enrico Bertino, Giuseppe Buonocore, Alessandra Coscia
Summary: This study investigated the effects of storing Human Milk at 4 degrees C for up to 96 hours on oxidative stress markers Isoprostanes. The results showed that refrigeration under controlled conditions did not significantly affect the bioactivity and nutritional quality of Human Milk related to these biomarkers.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Francesca Monari, Giuseppe Chiossi, Giancarlo Gargano, Michela Ballarini, Dante Baronciani, Alessandra Coscia, Fabio Facchinetti
Summary: This study aimed to investigate the adverse outcomes in late preterm (LP) babies and their association with gestational age at delivery, delivery indication, and prenatal risk factors. The results showed that LP babies delivered at 34 and 35 weeks had a higher risk of adverse outcomes compared to those delivered at 36 weeks, and indicated deliveries were also associated with worse outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Editorial Material
Nutrition & Dietetics
Enrico Bertino, Massimo Agosti, Chiara Peila, Marinella Corridori, Roberta Pintus, Vassilios Fanos
Article
Food Science & Technology
Chiara Peila, Stefano Sottemano, Flaminia Cesare Marincola, Matteo Stocchero, Nicoletta Grazia Pusceddu, Angelica Dessi, Eugenio Baraldi, Vassilios Fanos, Enrico Bertino
Summary: This study longitudinally investigated the metabolome of milk from women delivering preterm at different gestational ages. The study found that both the mother's phenotype and lactation time had a significant impact on the metabolome composition of human milk. Additionally, statistically significant differences in terms of gestational age were observed. These findings provide insights into optimizing feeding and improving outcomes for preterm newborns.
Article
Nutrition & Dietetics
Alessandra Coscia, Lorenzo Riboldi, Elena Spada, Enrico Bertino, Stefano Sottemano, Ignazio Barbagallo, Giovanni Livolti, Fabio Galvano, Diego Gazzolo, Chiara Peila
Summary: This study investigated the effects of preeclampsia on activin A levels and found that the lactation phase had a significant effect on the concentration of activin A, while there were no significant differences between preeclamptic and normotensive women. The results suggest that the beneficial properties of breast milk can be maintained even if preeclampsia occurs.
Article
Nutrition & Dietetics
Chiara Peila, Lorenzo Riboldi, Elena Spada, Alessandra Coscia, Ignazio Barbagallo, Giovanni Li Volti, Fabio Galvano, Diego Gazzolo
Summary: The study aimed to evaluate the impact of preeclampsia and gestational diabetes mellitus on the redox homeostasis of human milk. The results showed that gestational diabetes mellitus may affect the glutathione level in breast milk.