期刊
PEDIATRIC RESEARCH
卷 79, 期 1, 页码 49-54出版社
SPRINGERNATURE
DOI: 10.1038/pr.2015.188
关键词
-
类别
资金
- National Institutes of Health (NIH
- Bethesda, MD) the National Heart, Lung, and Blood Institute/NIH [R01HL110957]
- National Center for Advancing Translational Sciences/NIH [UL1TR000114]
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/NIH NORC [P30 DK050456]
- NIDDK/NIH [T32-DK083250]
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000114] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [F32HL127851, R01HL110957] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [T32DK083250, P30DK050456] Funding Source: NIH RePORTER
BACKGROUND: We examined whether sympathetic nervous system activity influences hypertension status and systolic blood pressure (SBP) independent of adiposity in youth ranging from normal-weight to severe obesity. METHODS: We examined the association of heart rate variability (HRV) with hypertension status and SBP among youth (6-18 y old; n = 188; 103 female). Seated SBP was measured using an automated cuff. Prehypertension (SBP percentile >= 90th to <95th) and hypertension (SBP percentile >= 95th) were defined by age-, sex-, and height-norms. Autonomic nervous system activity was measured using HRV via SphygmoCor MM3 system and analyzed for time- and frequency-domains. Total body fat was measured via dual-energy X-ray absorptiometry. RESULTS: Logistic regression models demonstrated lower values in each time-domain HRV measure and larger low frequency (LF):high-frequency (HF) ratio to be significantly associated with higher odds of being prehypertensive/hypertensive (11-47% higher odds) independent of total body fat (P < 0.05). In linear regression analysis, lower time-domain, but not frequency-domain, HRV measures were significantly associated with higher SBP independent of total body fat (P < 0.05). CONCLUSION: These data suggest that impaired cardiac autonomic nervous system function, at rest, is associated with higher odds of being prehypertensive/hypertensive and higher SBP which may be independent of adiposity in youth.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据