期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 57, 期 18, 页码 7577-7589出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm500510f
关键词
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HGF/c-Met signaling has been implicated in human cancers. Herein we describe the invention of a series of novel triazolopyrazine c-Met inhibitors. The structure activity relationship of these compounds was investigated, leading to the identification of compound 28, which demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.
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