期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 57, 期 13, 页码 5817-5822出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm500246h
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资金
- EPSRC [EP/G007578/1]
- ISSF grant from the Wellcome Trust
- KU Leuven [GOA 10/014]
- EPSRC [EP/G007578/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/G007578/1, 1206129] Funding Source: researchfish
Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.
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