Article
Allergy
Maria Elena Maccari, Pascal Schneider, Cristian Roberto Smulski, Andrea Meinhardt, Fernando Pinto, Luis Ignacio Gonzalez-Granado, Catharina Schuetz, Mauricio Pablo Sica, Miriam Gross, Ilka Fuchs, Patrick Kury, Maximilian Heeg, Tatjana Vocat, Laure Willen, Caroline Thomas, Regina Huehn, Aude Magerus, Myriam Lorenz, Klaus Schwarz, Frederic Rieux-Laucat, Stephan Ehl, Anne Rensing-Ehl
Summary: Heterozygous loss-of-function mutations in FASLG are better tolerated than in FAS, and usually do not result in expanded double-negative T cells (DNT) and elevated serum vitamin B12 levels, which are characteristic of autoimmune-lymphoproliferative syndrome (ALPS).
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Microbiology
Jin Hua Liang, Chong Wang, Stephanie Pei Tung Yiu, Bo Zhao, Rui Guo, Benjamin E. Gewurz
Summary: EBV infection is associated with various cancers, with CTPS1 and CTPS2 potentially playing important roles in EBV-infected B cells. Lack of CTPS1 can impact EBV DNA synthesis, while deficiency of both CTPS1 and CTPS2 leads to stronger phenotypes, suggesting CTPS1/2 as potential therapeutic targets for EBV-driven lymphoproliferative disorders.
Article
Immunology
Kefeng Shen, Jiachen Wang, Kuangguo Zhou, Wei Mu, Meilan Zhang, Xinyue Deng, Haodong Cai, Wei Zhang, Wei Huang, Min Xiao
Summary: This study reports the first case of CD137 deficiency caused by two novel biallelic heterozygous TNFRSF9 mutations. The mutations resulted in reduced or abrogated expression of CD137 on activated T, B, and NK cells, leading to impaired immune function and increased susceptibility to EBV-associated lymphoproliferative disease.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2023)
Article
Immunology
Maria Elena Maccari, Sebastian Fuchs, Patrick Kury, Geoffroy Andrieux, Simon Volkl, Bertram Bengsch, Myriam Ricarda Lorenz, Maximilian Heeg, Jan Rohr, Sabine Jagle, Carla N. Castro, Miriam Gross, Ursula Warthorst, Christoph Koenig, Ilka Fuchs, Carsten Speckmann, Julian Thalhammer, Friedrich G. Kapp, Markus G. Seidel, Gregor Duckers, Stefan Schoenberger, Catharina Schuetz, Marita Fuhrer, Robin Kobbe, Dirk Holzinger, Christian Klemann, Petr Smisek, Stephen Owens, Gerd Horneff, Reinhard Kolb, Nora Naumann-Bartsch, Maurizio Miano, Julian Staniek, Marta Rizzi, Tomas Kalina, Pascal Schneider, Anika Erxleben, Rolf Backofen, Arif Ekici, Charlotte M. Niemeyer, Klaus Warnatz, Bodo Grimbacher, Hermann Eibel, Andreas Mackensen, Andreas Philipp Frei, Klaus Schwarz, Melanie Boerries, Stephan Ehl, Anne Rensing-Ehl
Summary: The identification and characterization of a population of FAS-controlled TCR alpha beta(+) T cells in autoimmune lymphoproliferative syndrome show numerous unique features, including a distinct molecular signature, high proliferation rates, noncytotoxicity, and IL-10 cytokine bias. Mechanistically, the regulation of this population involves FAS and CTLA4 signaling, as well as mTOR and STAT3 signals, and genetic alterations in these pathways can lead to significant lymphoproliferative disease.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Pediatrics
Claudia L. Gaefke, Jonathan Metts, Donya Imanirad, Daime Nieves, Paola Terranova, Gianluca Dell'Orso, Eleonora Gambineri, Maurizio Miano, Richard F. Lockey, Jolan Eszter Walter, Emma Westermann-Clark
Summary: ALPS is a disease with variable penetrance caused by mutations in the FAS gene, which can present with various symptoms. Prompt recognition and targeted therapy based on genetic testing are crucial for optimal management. A previously unreported FAS gene variant was identified in a cohort of ALPS patients, highlighting the importance of genetic testing in subjects with clinical features of the disease.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Hyun Ji Ha, Hyun Ho Park
Summary: In this study, the molecular mechanisms underlying the pathogenesis of the PIDD DD pathogenic variants R815W, R862W, and Q863stop were analyzed. It was found that these mutations prevented the interaction between PIDD and RAIDD, affecting PIDDosome formation and caspase-2 activation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Sofie Mossner, Doreen Manuela Floss, Juergen Scheller
Summary: Research focused on a synthetic cytokine receptor activation strategy, particularly highlighting the noncovalent trimers of the tumor necrosis factor superfamily, explored the impact of synthetic cytokine receptors on cellular signaling, showing the potential to induce pro-apoptotic and anti-apoptotic signaling through synthetic cytokine receptors.
Review
Immunology
Elise M. N. Ferre, Michail S. Lionakis
Summary: APECED is a monogenic disorder caused by biallelic mutations in the AIRE gene, characterized by chronic mucocutaneous candidiasis and autoimmune endocrinopathies. Recent research has highlighted the potential development of life-threatening non-endocrine manifestations like autoimmune pneumonitis in APECED patients. This review summarizes the clinical, diagnostic, and therapeutic aspects of APECED pneumonitis, and discusses the relevance of these findings to other interstitial lung diseases and autoimmune disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Wei Yu, Ping Shen, Yunbo Chen, Kai Zhou, Xiaohui Chi, Yonghong Xiao
Summary: This study aimed to investigate the mechanisms of decreased AZA susceptibility in bloodstream infection caused by carbapenem-resistant Klebsiella pneumoniae (CR-Kp). It was found that elevated inhibitory concentration of AZA emerged before previous clinical exposure, and decreased AZA susceptibility was associated with higher KPC expression and changes in OmpK35-37.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Hematology
Abdolreza Sotoodeh Jahromi, Mohammad Kargar, Farshid Kafilzadeh, Marzieh Jamalidoust, Maliheh Moradzadeh
Summary: The study demonstrated that crocin has the potential to induce apoptosis in CO 88BV59-1 cells, especially showing synergistic effects in EBV-associated disorders. Crocin exhibited no significant toxicity towards normal B cells, suggesting it as a possible treatment option.
MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Liyu Jiang, Yan Zeng, Leilei Ai, Hao Yan, Xiaochun Yang, Peihua Luo, Bo Yang, Zhifei Xu, Qiaojun He
Summary: The application of lapatinib, a dual inhibitor, is limited by its cutaneous toxicity. This study revealed that lapatinib-induced cutaneous toxicity is associated with mitochondrial dysfunction, DNA damage, apoptosis of keratinocytes, aberrant immune response, and release of inflammatory factors. Downregulated expression of the DNA repair protein HMGB1 played a critical role in these toxic reactions. Restoring HMGB1 expression might be an effective remedy for lapatinib-induced cutaneous toxicity. Additionally, saikosaponin A could rescue reduced HMGB1 transcription and alleviate lapatinib-induced DNA damage, keratinocyte apoptosis, and toxicity in mice.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medical Laboratory Technology
Mai Elzieny, Jordan A. Fisher, Matthew D. Sims, Carl B. Lauter, Robin A. Carey-Ballough, Qian Sun
Summary: This article reports a case of rheumatoid factor-mediated falsely low vancomycin measurement. Reanalyzing the sample with an alternative method, using heterophile blocking reagent and rheumatoid factor clean-up solution helped to solve the false results. The patient's vancomycin concentrations reached toxic levels and drug administration was immediately terminated. The patient experienced a transient increase in serum creatinine. Even though most immunoassays use blocking agents to neutralize interfering antibodies like rheumatoid factor, occasional interference can still occur.
CLINICA CHIMICA ACTA
(2023)
Article
Medicine, Research & Experimental
Yuki Sasaki, Hideki Arimochi, Kunihiro Otsuka, Hiroyuki Kondo, Shin-ichi Tsukumo, Koji Yasutomo
Summary: Immunoproteasome dysfunction leads to proteasome-associated autoinflammatory syndromes. In a mouse model, Psmb8 mutation causes hyperactivation of the CXCR3 pathway, resulting in increased susceptibility to skin inflammation.
Article
Biochemistry & Molecular Biology
Macarena Lopez-Sanchez, Carlos Loucera, Maria Pena-Chilet, Joaquin Dopazo
Summary: Recent studies have shown the importance of host genetics in the prognosis of COVID-19. This study used a mathematical mechanistic model to identify potential interactions between rare disease genes and the COVID-19 infection process. Out of the analyzed disease genes, 254 genes directly affect the COVID-19 molecular disease mechanism and 207 genes have an indirect effect. These findings suggest the potential for preventive measures in some rare diseases based on the links between disease genes and COVID-19 hallmarks.
HUMAN MOLECULAR GENETICS
(2022)
Article
Immunology
Laura Batlle-Maso, Marina Garcia-Prat, Alba Parra-Martinez, Clara Franco-Jarava, Aina Aguilo-Cucurull, Pablo Velasco, Maria Antolin, Jacques G. Riviere, Andrea Martin-Nalda, Pere Soler-Palacin, Monica Martinez-Gallo, Roger Colobran
Summary: This study illustrates the evolutionary dynamics of a somatic FAS mutation before and during immunosuppressive treatment in ALPS patients. The results show that pathogenic somatic FAS variants can be identified with the use of deep amplicon sequencing (DAS) in whole blood of ALPS patients regardless of their DNT counts.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Jennifer W. Leiding, Tiphanie P. Vogel, Valentine G. J. Santarlas, Rahul Mhaskar, Madison R. Smith, Alexandre Carisey, Alexander Vargas-Hernandez, Manuel Silva-Carmona, Maximilian Heeg, Anne Rensing-Ehl, Benedicte Neven, Jerome Hadjadj, Sophie Hambleton, Timothy Ronan Leahy, Kornvalee Meesilpavikai, Charlotte Cunningham-Rundles, Cullen M. Dutmer, Svetlana O. Sharapova, Mervi Taskinen, Ignatius Chua, Rosie Hague, Christian Klemann, Larysa Kostyuchenko, Tomohiro Morio, Akaluck Thatayatikom, Ahmet Ozen, Anna Scherbina, Cindy S. Bauer, Sarah E. Flanagan, Eleonora Gambineri, Lisa Giovannini-Chami, Jennifer Heimall, Kathleen E. Sullivan, Eric Allenspach, Nei Romberg, Sean G. Deane, Benjamin T. Prince, Melissa J. Rose, John Bohnsack, Talal Mousallem, Rohith Jesudas, Maria Marluce Dos Santos Vilela, Michael O'Sullivan, Jana Pachlopnik Schmid, Stepanka Pruhova, Adam Klocperk, Matthew Rees, Helen Su, Sami Bahna, Saf Baris, Lisa M. Bartnikas, Amy Chang Berger, Tracy A. Briggs, Shannon Brothers, Vanessa Bundy, Alice Y. Chan, Shanmuganathan Chandrakasan, Mette Christiansen, Theresa Cole, Matthew C. Cook, Mukesh M. Desai, Ute Fischer, David A. Fulcher, Silvanna Gallo, Amelie Gauthier, Andrew R. Gennery, Jose Goncalo Marques, Frederic Gottrand, Bodo Grimbacher, Eyal Grunebaum, Emma Haapaniemi, Sari Hamalainen, Kaarina Heiskanen, Tarja Heiskanen-Kosma, Hal M. Hoffman, Luis Ignacio Gonzalez-Granado, Anthony L. Guerrerio, Leena Kainulainen, Ashish Kumar, Monica G. Lawrence, Carina Levin, Timi Martelius, Olaf Neth, Peter Olbrich, Alejandro Palma, Niraj C. Patel, Tamara Pozos, Kahn Preece, Saul Oswaldo Lugo Reyes, Mark A. Russell, Yael Schejter, Christine Seroogy, Jan Sinclair, Effie Skevofilax, Daniel Suan, Daniel Suez, Paul Szabolcs, Helena Velasco, Klaus Warnatz, Kelly Walkovich, Austen Worth, Mikko R. J. Seppanen, Troy R. Torgerson, Georgios Sogkas, Stephan Ehl, Stuart G. Tangye, Megan A. Cooper, Joshua D. Milner, Lisa R. Forbes Satter
Summary: This pivotal cohort study defines the scope, natural history, treatment, and overall survival of a large global cohort of patients with pathogenic STAT3 GOF variants. The study found that patients with this variant present with a wide array of immune-mediated disease including lymphoproliferation, autoimmune cytopenias, and multisystem autoimmunity. Early identification and prompt treatment implementation are crucial for the survival of these patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Muskan Israni, Bethany Nicholson, Nizar Mahlaoui, Laura Obici, Linda Rossi-Semerano, Helen Lachmann, Georgia Hayward, Mojca Zajc Avramovic, Aurelien Guffroy, Virgil Dalm, Rachel Rimmer, Leire Solis, Carlotta Villar, Andrew R. Gennery, Stephanie Skeffington, Julia Nordin, Klaus Warnatz, Anne-Sophie Korganow, Jordi Anton, Marco Cattalini, Tania Amin, Stephan Berg, Pere Soler-Palacin, Siobhan O. Burns, Mari Campbell
Summary: This study aims to understand the prevalence and practice of transition services for young people with IEI in Europe. The survey results showed that almost all services transitioned patients to adult services, but there is a lack of standardized guidelines.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Maria Elena Maccari, Pascal Schneider, Cristian Roberto Smulski, Andrea Meinhardt, Fernando Pinto, Luis Ignacio Gonzalez-Granado, Catharina Schuetz, Mauricio Pablo Sica, Miriam Gross, Ilka Fuchs, Patrick Kury, Maximilian Heeg, Tatjana Vocat, Laure Willen, Caroline Thomas, Regina Huehn, Aude Magerus, Myriam Lorenz, Klaus Schwarz, Frederic Rieux-Laucat, Stephan Ehl, Anne Rensing-Ehl
Summary: Heterozygous loss-of-function mutations in FASLG are better tolerated than in FAS, and usually do not result in expanded double-negative T cells (DNT) and elevated serum vitamin B12 levels, which are characteristic of autoimmune-lymphoproliferative syndrome (ALPS).
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Letter
Immunology
Yanick J. Crow
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Brigette Boast, Shubham Goel, Luis I. Gonzalez-Granado, Julie Niemela, Jennifer Stoddard, Emily S. J. Edwards, Sandali Seneviratne, Dominik Spensberger, Juan F. Quesada -Espinosa, Luis M. Allende, John Mcdonnell, Alexandria Haseley, Harry Lesmana, Magdalena A. Walkiewicz, Emad Muhammad, Julian J. Bosco, Thomas A. Fleisher, Shai Cohen, Steven M. Holland, Menno C. van Zelm, Anselm Enders, Hye Sun Kuehn, Sergio D. Rosenzweig
Summary: TCF3 gene plays an important role in early lymphocyte differentiation. Mutations in TCF3 can cause immunodeficiency, but the type of genetic mutation can affect the severity and manifestation of the disease. Research suggests that monoallelic mutations in TCF3 may lead to reduced expression of TCF3 protein, B-cell defects, and dysregulated immune response.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Marta Lopez-Nevado, Julian Sevilla, Patricia Almendro-Vazquez, Francisco J. Gil-Etayo, Sara Garcinuno, Antonio Serrano-Hernandez, Estela Paz-Artal, Luis I. Gonzalez-Granado, Luis M. Allende
Summary: Human inborn errors of immunity affecting the IFN-I induction pathway have been associated with severe viral infections, including hemophagocytic lymphohistiocytosis. This article reports a case of complete STAT2 deficiency in a child who developed HLH after vaccination and later MIS-C after SARS-CoV-2 infection. Functional studies revealed impaired IFN-I-induced response and defective IFN alpha expression, suggesting a complex mechanism for hyperinflammatory reactions in these patients.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang, Jeremy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi, Hassan Abolhassani, Ahmad Abou Tayoun, Alessandro Aiuti, Ilad Alavi Darazam, Luis M. Allende, Rebeca Alonso-Arias, Andres Augusto Arias, Gokhan Aytekin, Peter Bergman, Simone Bondesan, Yenan T. Bryceson, Ingrid G. Bustos, Oscar Cabrera-Marante, Sheila Carcel, Paola Carrera, Giorgio Casari, Khalil Chaibi, Roger Colobran, Antonio Condino-Neto, Laura E. Covill, Ottavia M. Delmonte, Loubna El Zein, Carlos Flores, Peter K. Gregersen, Marta Gut, Filomeen Haerynck, Rabih Halwani, Selda Hancerli, Lennart Hammarstroem, Nevin Hatipoglu, Adem Karbuz, Sevgi Keles, Christele Kyheng, Rafael Leon-Lopez, Jose Luis Franco, Davood Mansouri, Javier Martinez-Picado, Ozge Metin Akcan, Isabelle Migeotte, Pierre-Emmanuel Morange, Guillaume Morelle, Andrea Martin-Nalda, Giuseppe Novelli, Antonio Novelli, Tayfun Ozcelik, Figen Palabiyik, Qiang Pan-Hammarstroem, Rebeca Perez de Diego, Laura Planas-Serra, Daniel E. Pleguezuelo, Carolina Prando, Aurora Pujol, Luis Felipe Reyes, Jacques G. Riviere, Carlos Rodriguez-Gallego, Julian Rojas, Patrizia Rovere-Querini, Agatha Schlueter, Mohammad Shahrooei, Ali Sobh, Pere Soler-Palacin, Yacine Tandjaoui-Lambiotte, Imran Tipu, Cristina Tresoldi, Jesus Troya, Diederik van de Beek, Mayana Zatz, Pawel Zawadzki, Saleh Zaid Al-Muhsen, Mohammed Faraj Alosaimi, Fahad M. Alsohime, Hagit Baris-Feldman, Manish J. Butte, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Jacques Fellay, James R. Heath, Yu-Lung Lau, Richard P. Lifton, Tom Maniatis, Trine H. Mogensen, Horst von Bernuth, Alban Lermine, Michel Vidaud, Anne Boland, Jean-Francois Deleuze, Robert Nussbaum, Amanda Kahn-Kirby, France Mentre, Sarah Tubiana, Guy Gorochov, Florence Tubach, Pierre Hausfater, C. O. V. I. D. Human Genetic Effort, Isabelle Meyts, Shen-Ying Zhang, Anne Puel, Luigi D. Notarangelo, Stephanie Boisson-Dupuis, Helen C. Su, Bertrand Boisson, Emmanuelle Jouanguy, Jean-Laurent Casanova, Qian Zhang, Laurent Abel, Aurelie Cobat
Summary: Through a genome-wide rare variant burden association analysis, it was found that there is an association between at-risk variants in the TLR7 gene and rare loss-of-function variants in TLR3-dependent type I interferon immunity genes. These findings suggest that rare variants in TLR3- and TLR7-dependent type I interferon immunity genes may underlie life-threatening COVID-19 in patients under 60 years old.
Article
Immunology
Cristina Arnaldos-Perez, Andreu Vilaseca, Laura Naranjo, Lidia Sabater, Josep Dalmau, Raquel Ruiz-Garcia, Francesc Graus
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Pediatrics
Andrew R. Gennery, Luis I. Gonzalez-Granado, Troy R. Torgerson
FRONTIERS IN PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Bergithe E. Oftedal, Kristian Assing, Safa Baris, Stephanie L. Safgren, Isik S. Johansen, Marianne Antonius Jakobsen, Dusica Babovic-Vuksanovic, Katherine Agre, Eric W. Klee, Emina Majcic, Elise M. N. Ferre, Monica M. Schmitt, Tom DiMaggio, Lindsey B. Rosen, Muhammad Obaidur Rahman, Dionisio Chrysis, Aristeidi Giannakopoulos, Maria Tallon Garcia, Luis Ignacio Gonzalez-Granado, Katherine Stanley, Jessica Galant-Swafford, Pim Suwannarat, Isabelle Meyts, Michail S. Lionakis, Eystein S. Husebye
Summary: APS-1 is an autosomal recessive disease caused by mutations in the AIRE gene, characterized by severe and childhood onset organ-specific autoimmunity. Dominant-negative mutations in PHD1, PHD2, and SAND domains have also been associated with a milder phenotype. This study identified additional families with a range of phenotypes and emphasized the need for functional studies and close follow-up of individuals and families.
Article
Clinical Neurology
Thais Armangue, Gemma Olive-Cirera, Eugenia Martinez-Hernandez, Maria Rodes, Vicente Peris-Sempere, Mar Guasp, Raquel Ruiz, Eduard Palou, Azucena Gonzalez, Ma angeles Marcos, Maria Elena Erro, Luis Bataller, Inigo Corral-Corral, Jesus Planaguma, Eva Caballero, Alexandru Vlagea, Jie Chen, Paul Bastard, Marie Materna, Astrid Marchal, Laurent Abel, Aurelie Cobat, Laia Alsina, Claudia Fortuny, Albert Saiz, Emmanuel Mignot, Adeline Vanderver, Jean-Laurent Casanova, Shen-Ying Zhang, Josep Dalmau, Spanish HSE Study Grp
Summary: Patients with herpes simplex virus encephalitis often develop neuronal autoantibody-associated encephalitis post-infection. This study found that risk factors for post-HSE AE may include genetic variants, HLA haplotypes, and the blood innate immune response against HSV. These findings have potential clinical applications for the diagnosis and monitoring of HSE complications.
Editorial Material
Clinical Neurology
Andreu Vilaseca, Elena Martinez-Saez, Victoria Gonzalez, Cristina Auger, Laura Naranjo, Raquel Ruiz-Garcia
Summary: Paraneoplastic cerebellar degeneration (PCD) has been observed in a small number of patients with melanoma and specific neuronal antibodies (Yo and CARPVIII).
Article
Clinical Neurology
Laura Perez-Carbonell, Jordi Sarto, Carles Gaig, Amaia Munoz-Lopetegi, Raquel Ruiz-Garcia, Laura Naranjo, Josep Maria Auge, Andres Perissinotti, Joan Santamaria, Alex Iranzo, Raquel Sanchez-Valle
Summary: This study evaluated the sleep in three cases of GSS and found that their sleep staging was normal. However, some patients experienced reduced sleep efficiency, confusional arousal, obstructive apneas, and periodic leg movements during sleep.
Article
Orthopedics
Jorge Calvo, Llipsy Santiago, Maykel Arias, Julian Pardo, Jorge Albareda, Luis Martinez-Lostao, Felicito Garcia-Alvarez
Summary: This study aims to assess the development of osteoarthritis (OA) in granzyme A (gzmA) and B (gzmB) and perforin (perf) knockout mice. The results show that sex plays an important role in the development of experimental OA in mice. Deficiency of gzmA can protect female mice from the development of OA.
JOINT DISEASES AND RELATED SURGERY
(2023)
Meeting Abstract
Clinical Neurology
Elianet Fonseca, Jose Maria Cabrera Maqueda, Raquel Ruiz-Garcia, Laura Naranjo, Yolanda Blanco Morgado, Josep Dalmau, Francesc Graus, Eugenia Martinez-Hernandez