Article
Medicine, Research & Experimental
Asser F. Bedair, Ahmed Wahid, Nesrine S. El-Mezayen, Elham A. Afify
Summary: This study investigated the effects of morphine and nicorandil in liver fibrosis and found that the combination of nicorandil and morphine can enhance hepatoprotection and provide persistent analgesia, while reducing morphine dependence.
Article
Behavioral Sciences
Nicole M. Hinds, Ireneusz D. Wojtas, Corinne A. Gallagher, Claire M. Corbett, Daniel F. Manvich
Summary: In this study, researchers found that the effects and rewarding properties of oxycodone are not influenced by sex, but vary across the estrous cycle in female rats. These findings are important for the treatment and prevention of oxycodone misuse.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Anesthesiology
Yang Ren, Yinhui Zhou, Zerong You, Hao Deng, William R. Kem, Jianren Mao, Wei Zhang, J. A. Jeevendra Martyn
Summary: This study found that morphine exacerbates burn injury-site pain and microglia activation, while GTS-21 alleviates morphine-induced pain and microglia activation in burn injury.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Neurosciences
C. Austin Zamarripa, Tanya Pareek, Hayley M. Schrock, Thomas E. Prisinzano, Bruce E. Blough, Kenneth J. Sufka, Kevin B. Freeman
Summary: Triazole 1.1 is a novel KOR agonist that can reduce the reinforcing effects of oxycodone and enhance oxycodone-induced antinociception to a degree similar to typical KOR agonists. Developing MOR-KOR agonist combinations from the triazole 1.1 series may lead to new pain therapeutics with reduced abuse liability.
PSYCHOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Ariana C. Brice-Tutt, Darrice S. Montgomery, Cassidy M. Kramer, Peter M. Novotny, Wendi L. Malphurs, Abhisheak Sharma, Robert. M. Caudle, Adriaan W. Bruijnzeel, Barry Setlow, John K. Neubert, Niall P. Murphy
Summary: This study found that there are inter-relationships between pain sensitivity, drug reward, and drug misuse. Rats were tested for pain sensitivity, conditioned place preference to oxycodone, and the impact of neuropathic pain on pain sensitivity and reinstatement of conditioned place preference. The results suggest that high rates of behavioral sensitization predict faster rates of extinction of oxycodone seeking/reward, and cutaneous thermal reflex pain may be predictive of both.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Conor M. Eufemio, Joseph D. Hagedorn, Kenneth L. McCall, Brian J. Piper
Summary: This study conducted a comprehensive investigation and analysis of upstream gene variants in specific areas of malignant tumors, identified the patterns of upstream gene variants in different types of malignant tumors in that area, and made suggestions for further research.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, Legal
Martin M. Kimani, Adam Lanzarotta, JaCinta S. Batson
Summary: The opioid crisis in the USA has led to a high number of overdose fatalities. A rapid and sensitive SERS method has been developed for detecting opioid drugs in low-dosage suspect tablets, showing high efficiency and sensitivity.
JOURNAL OF FORENSIC SCIENCES
(2021)
Article
Neurosciences
Kristen N. Amico, Miranda E. Arnold, Morgan S. Dourron, Matthew G. Solomon, Jesse R. Schank
Summary: This study found that female rats consumed more alcohol and oxycodone than males when given access to both drugs. The effect on alcohol intake persisted even when oxycodone was removed. Re-exposure to oxycodone cues and the administration of the stressor yohimbine drove reinstatement of oxycodone-seeking behavior in females, but not in males, possibly due to lower levels of oxycodone intake in male rats during active self-administration. Additionally, yohimbine increased alcohol consumption.
PSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Brenda M. Gannon, Kenner C. Rice, Kevin S. Murnane
Summary: The study found that high-responders to MDPV were more effective at maintaining peak levels of behavior compared to oxycodone and resulted in greater overall drug intake. High-responders also self-administered more oxycodone under an FR5 schedule of reinforcement, but this was not accompanied by increased levels of timeout responding.
PSYCHOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Morgan L. Crowley, Luis F. Restrepo, Lea R. Gamez-Jimenez, Avi Patel, Tobias Braun, Victoria L. C. Pallares, Nicholas P. Ho, Morgan E. Reeves, Christopher R. McCurdy, Lance R. McMahon, Takato Hiranita
Summary: Using hypercapnia-induced increases in respiration as a strategy to assess opioid-induced decreases in respiration in rats is highly sensitive to opioid-induced respiratory depression, providing a useful method for assessment in a preclinical setting.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2021)
Article
Food Science & Technology
Haneul Lee, Eun Young Kang, Joowon Lee, Yejin Kim, Sumin Kang, Hayoon Kim, Hyun Kyung Kim, Gyoungok Gang, Sang-gil Lee, Cao Lei, Gwang-woong Go
Summary: Extract of Schisandra chinensis can effectively reduce plasma and hepatic triglyceride levels induced by high-sucrose diet, by decreasing the activity of hepatic lipogenic enzymes to reduce fat accumulation. This suggests that Schisandra chinensis has the potential for prevention and treatment of hepatic steatosis.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Michael D. Raleigh, Claudia Accetturo, Marco Pravetoni
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2020)
Article
Pharmacology & Pharmacy
Carly Baehr, April Huseby Kelcher, Aaron Khaimraj, Dana E. Reed, Sujata G. Pandit, David AuCoin, Saadyah Averick, Marco Pravetoni
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2020)
Article
Immunology
Bethany Crouse, Christine Robinson, April Huseby Kelcher, Megan Laudenbach, Juan E. Abrahante, Marco Pravetoni
Article
Immunology
Addison E. Stone, Sarah E. Scheuermann, Colin N. Haile, Gregory D. Cuny, Marcela Lopez Velasquez, Joshua P. Linhuber, Anantha L. Duddupudi, Jennifer R. Vigliaturo, Marco Pravetoni, Therese A. Kosten, Thomas R. Kosten, Elizabeth B. Norton
Summary: This study evaluated adjuvant and delivery strategies for vaccines targeting fentanyl, finding that dmLT or LTA1 adjuvants as well as mucosal delivery may be attractive strategies for improving the efficacy of vaccines against SUD.
Article
Immunology
April M. Huseby Kelcher, Carly A. Baehr, Fatima A. Hamid, Geoffrey T. Hart, Marco Pravetoni
Summary: Vaccines and monoclonal antibodies show promise in treating substance use disorders and preventing overdose, with FcRn identified as playing a role in their efficacy. Phagocytosis or Fc-dependent effector functions are not required for the efficacy of vaccines and mAbs against SUD, according to this study.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Bethany Crouse, Li Zhang, Christine Robinson, Yuguang Ban, Jennifer R. Vigliaturo, Sabita Roy, Marco Pravetoni
Summary: This study showed that housing mice and rats in either conventional or specific pathogen-free environment did not affect vaccine-induced antibody responses against oxycodone and fentanyl, nor their efficacy against oxycodone- and fentanyl-induced antinociception, respiratory depression, and bradycardia. Differences in the GI microbiome detected via 16S rRNA gene sequencing were related to the housing environment.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Chemistry, Analytical
Leah M. Dignan, M. Shane Woolf, Jennifer A. Ross, Carly Baehr, Christopher P. Holstege, Marco Pravetoni, James P. Landers
Summary: This study introduces a portable centrifugal microfluidic ELISA system that replaces repetitive pipetting with rotationally controlled fluidics, allowing for sensitive and reliable colorimetric detection of opiates. This new approach could provide rapid and automatable drug detection outside of traditional laboratories by non-technical personnel.
ANALYTICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Carly A. Baehr, Mariah M. Wu, Sujata G. Pandit, Jose Arias-Umana, David AuCoin, Marco Pravetoni
Summary: The incidence of fatal drug overdoses in the US has increased due to the COVID-19 pandemic, with a significant portion attributed to fentanyl. A study has shown that the monoclonal antibody HY6-F9 can effectively reverse fentanyl-induced toxicity and protect against additional challenges. When used in combination with naloxone, the antibody provides greater protection. These findings support the use of monoclonal antibodies as medical interventions for fentanyl-related overdose prevention and reversal.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Carly Baehr, Christine Robinson, Andrew Kassick, Rajwana Jahan, Valeria Gradinati, Saadyah E. Averick, Scott P. Runyon, Marco Pravetoni
Summary: The ongoing public health emergency of opioid use disorders and overdose in the United States, driven by fentanyl and its analogues, calls for alternative interventions. A study compared different vaccines targeting fentanyl and its analogues and found that a lead conjugate vaccine was effective in reducing the pharmacological effects induced by these substances in rats.
Article
Biotechnology & Applied Microbiology
Dustin Hicks, Carly Baehr, Pedro Silva-Ortiz, Aaron Khaimraj, Diego Luengas, Fatima A. Hamid, Marco Pravetoni
Summary: Novel humanized anti-fentanyl monoclonal antibodies were developed and shown to effectively counteract the pharmacological effects of fentanyl, suggesting their potential for treating fentanyl toxicity.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Review
Pharmacology & Pharmacy
Rachel Luba, Suky Martinez, Jermaine Jones, Marco Pravetoni, Sandra D. Comer
Summary: This article provides an overview of the development and mechanisms of vaccines for substance use disorders. It focuses on existing preclinical and clinical trials and offers an expert opinion on the future work of vaccines for opioid use disorder. The authors emphasize the urgent need for effective treatments, including vaccines, to combat the current opioid crisis.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Editorial Material
Pharmacology & Pharmacy
Suky Martinez, Hannah Harris, Thomas Chao, Rachel Luba, Marco Pravetoni, Sandra D. Comer, Jermaine D. Jones
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Chemistry, Medicinal
Bethany Crouse, Mariah M. Wu, Valeria Gradinati, Andrew J. Kassick, Daihyun Song, Rajwana Jahan, Saadyah Averick, Scott Runyon, Sandra D. Comer, Marco Pravetoni
Summary: The widespread availability of illicit fentanyl and other potent synthetic opioids has led to a significant increase in drug-related fatal overdoses over the past decade. Vaccination strategies that target carfentanil and fentanyl offer a promising approach to reducing fatalities associated with these substances and providing treatment for opioid use disorder. Preclinical studies have shown that mono- and bivalent vaccines can effectively protect against the pharmacological effects of carfentanil, fentanyl, and their mixtures.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2022)
Article
Chemistry, Medicinal
Andrew J. Kassick, Mariah Wu, Diego Luengas, Mohammad Ebqa'ai, L. P. Tharika Nirmani, Nestor Tomycz, Toby L. Nelson, Marco Pravetoni, Michael D. Raleigh, Saadyah Averick
Summary: This report describes a novel nanoparticle-based naloxone formulation that offers extended protection against the toxic effects of the synthetic opioid fentanyl. Pharmacokinetic evaluation revealed a significantly longer elimination half-life compared to high dose free naloxone in rats, and in vivo studies showed protection against fentanyl-induced respiratory depression and antinociception for up to 48 hours following a single injection. These findings support further investigation of this formulation as a potential therapeutic option for reversing opioid overdose and preventing renarcotization from potent opioids like fentanyl.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Andrew J. Kassick, Heather N. Allen, Saigopalakrishna S. Yerneni, Fathima Pary, Marina Kovaliov, Cooper Cheng, Marco Pravetoni, Nestor D. Tomycz, Donald M. Whiting, Toby L. Nelson, Michael Feasel, Phil G. Campbell, Benedict Kolber, Saadyah Averick
ACS APPLIED BIO MATERIALS
(2019)