期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 55, 期 15, 页码 6980-6984出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm300749q
关键词
-
资金
- Grants-in-Aid for Scientific Research [22240091, 23300348] Funding Source: KAKEN
To develop a boron carrier for practical purposes, new boron-containing amino acids with an undecahydro-closo-dodecaboranylthio ([(B12H11S)-B-10](2-)-) unit in the side chain of the a-amino acid have already been designed and synthesized. In the present paper, cytotoxicity, the incorporation amounts into tumor cells, and the tumor cell killing effects of these compounds were elucidated to evaluate their usefulness as boron carriers. Furthermore, the microdistribution of the amino acids in tumor cells was established.
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