Review
Peripheral Vascular Disease
J. David Spence, Tilo Grosser, Garret A. FitzGerald
Summary: Recent studies have questioned the safety of using acetaminophen for pain relief and fever reduction in patients with cardiovascular disease and those taking anticoagulants. The studies suggest that acetaminophen, like most nonsteroidal anti-inflammatory drugs, can increase blood pressure and formulations containing sodium can increase cardiovascular risk. The influence of acetaminophen on coagulation through its effects on vitamin K metabolism is also discussed.
Review
Pharmacology & Pharmacy
Daniela Placha, Josef Jampilek
Summary: Inflammatory diseases are becoming a significant issue, causing damage to affected tissues as a physiological response to harmful agents. There is ongoing research to develop new drugs to modulate inflammatory responses, as well as exploring the use of nanodrug delivery systems for targeted treatment.
Article
Immunology
Jing Zhang, Hongguang Sheng, Xiaoyi Tang, Panpan Xia, Zhangwang Li, Minxuan Xu, Jianyong Ma, Yunfeng Shen, Peng Yu, Xiao Liu
Summary: According to a post-hoc analysis from the ORCHID trial, the use of non-steroidal anti-inflammatory drugs (NSAIDs) in hospitalized American adult COVID-19 patients is not associated with worse clinical outcomes, including 28-day mortality or hospital discharge. Furthermore, a meta-analysis of 14 studies involving 48,788 COVID-19 patients showed that NSAID use had a survival benefit and decreased the risk of severe COVID-19.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Analytical
Ruijuan Zheng, Yingchen Yang, Chang Yang, Yan Xia
Summary: A core-shell material (UiO@TapbTp) has been developed for detecting nonsteroidal anti-inflammatory drugs by MALDI-TOF MS, showing improved enrichment ability and matrix performance. Pre-enrichment under optimized conditions significantly reduces the detection limits of drugs, with good recoveries in complex samples like saliva and environmental water.
Article
Oncology
Kate R. Pawloski, Regina Matar, Varadan Sevilimedu, Audree B. Tadros, Laurie J. Kirstein, Hiram S. Cody, Kimberly J. Van Zee, Monica Morrow, Tracy-Ann Moo
Summary: A retrospective study found that NSAIDs are associated with a low risk of hematoma after lumpectomy and SLNB. Discharge with NSAIDs did not increase the risk of hematoma compared to opioid discharge, and NSAIDs should be prescribed as the preferred option.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Francesco Caruso, Jens Z. Pedersen, Sandra Incerpi, Sarjit Kaur, Stuart Belli, Radu-Mihai Florea, Miriam Rossi
Summary: This study analyzed the inhibition of caspase-1 by anti-inflammatory drugs in COVID-19 treatment and investigated their antioxidant activities. The results suggest that these drugs alleviate excessive cytokine production by inhibiting caspase-1 and scavenging superoxide radicals. The mechanism involves the binding of the drugs to the active site of caspase-1, forming a covalent bond with a carbonyl group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Fatemeh Babaei, Mohammadreza Mirzababaei, Alireza Tavakkoli, Marjan Nassiri-Asl, Hossein Hosseinzadeh
Summary: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of musculoskeletal disorders, pain, and fever. This review explores the antifungal effects of NSAIDs alone or in combination with antifungal drugs in vitro and in vivo. Studies have shown that NSAIDs have antifungal activities against various species of fungi, including inhibiting biofilm formation and yeast-to-hypha conversion. Modulating prostaglandin E2 levels during fungal infection may be a possible mechanism. The combination therapy of NSAIDs and antifungal drugs shows potential as a novel therapeutic strategy in clinical studies, reducing resistance and toxicity.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Hye Jin Cho, Eunyoung Kang, Seonghoon Kim, D. ChangMo Yang, Joohan Nam, Eunji Jin, Jinhyu Lee, Wonyoung Choe
Summary: In this study, a water-stable Zr-based porphyrinic metal-organic framework (MOF), PCN-224, was used for the targeted adsorption of nonsteroidal anti-inflammatory drugs. The results showed high removal efficiencies for NPX and IBP, but lower efficiency for SMX. The strong interaction between the carboxylic acid functional groups in drugs and the open metal sites of PCN-224 was found to be responsible for the high adsorption capacity.
ACS APPLIED NANO MATERIALS
(2023)
Review
Agriculture, Multidisciplinary
Lawrence Mzukisi Madikizela, Tarryn Lee Botha, Ilunga Kamika, Titus Alfred M. Msagati
Summary: This article provides a critical review of the plant uptake, translocation, and toxic effects of pharmaceuticals in contaminated environments, including the presence of metabolites of these drugs in plants. The use of constructed wetlands with plants for remediation is also discussed. Factors influencing the plant uptake and translocation of pharmaceuticals are examined, and future research directions are suggested.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Andrew Y. Hwang, Steven M. Smith
Summary: Prescription NSAID use among patients with CVD has declined from 1988 to 2016, primarily due to reduced COX-2-selective inhibitor use. Nonetheless, the prevalence of prescription NSAIDs has persisted among a subset of high-risk CVD populations.
Review
Orthopedics
Nelson F. Athow, Patrick M. Morgan, Gregory A. Brown
Summary: The study found that hip and/or knee osteoarthritis is associated with an increased risk of cardiovascular disease morbidity and mortality, but did not show a link between nonselective NSAID use and cardiovascular risk. Factors such as the use of walking aids and walking difficulties may increase cardiac risk.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Chemistry, Multidisciplinary
Deqing Lin, Xiaoning Xu, Lin Chen, Lei Chen, Mengyun Deng, Jinrun Chen, Zhibin Ren, Lei Lei, Jiaqing Wang, Jie Deng, Xingyi Li
Summary: A facile method for converting carboxylate-containing indomethacin into a cyclooxygenase-2 selective inhibitor via the amidation of an unnatural peptide sequence is reported. The resulting indomethacin amides have high selectivity for COX-2 and can self-assemble into a supramolecular hydrogel for boosting anti-inflammatory efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
Bofei Li, Ka Shing Cheung, Ian Yu-Hong Wong, Wai Keung Leung, Simon Law
Summary: The study found that nonaspirin nonsteroidal anti-inflammatory drugs (NA-NSAIDs) did not reduce the risk of gastric cancer in patients who underwent Helicobacter pylori eradication, suggesting that the chemopreventive effect of NA-NSAIDs observed in prior studies may have been confounded by immortal time bias.
Article
Pharmacology & Pharmacy
Vanessa D'Antongiovanni, Luca Antonioli, Laura Benvenuti, Carolina Pellegrini, Clelia Di Salvo, Marco Calvigioni, Adelaide Panattoni, Larisa Ryskalin, Gianfranco Natale, Sebastiano Banni, Gianfranca Carta, Emilia Ghelardi, Matteo Fornai
Summary: Treatment with Saccharomyces boulardii CNCM I-745 prevents diclofenac-induced enteropathy through anti-inflammatory and antioxidant activities, likely by improving butyrate uptake by the enteric mucosa.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xie-Yuan Leng, Chang-Ning Liu, Shi-Chan Wang, Hao-Dong Peng, De-Guang Wang, Hai-Feng Pan
Summary: This study conducted a systematic review and meta-analysis to compare the effectiveness and safety between NSAIDs and opioids in the treatment of acute renal colic. The results showed no significant differences in various outcomes between these two treatment options, but patients treated with NSAIDs experienced fewer side effects.
FRONTIERS IN PHARMACOLOGY
(2022)