Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase
JOURNAL OF MEDICINAL CHEMISTRY (2010)
期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 53, 期 10, 页码 3973-4001出版社
AMER CHEMICAL SOC
关键词
作者
我是这篇论文的作者
推荐
Discovery of first-in-class imidazothiazole-based potent and selective ErbB4 (HER4) kinase inhibitors
Seyed-Omar Zaraei, Rawan M. Sbenati, Nour N. Alach, Hanan S. Anbar, Randa El-Gamal, Hamadeh Tarazi, Mahmoud K. Shehata, Mohammed S. Abdel-Maksoud, Chang-Hyun Oh, Mohammed El-Gamal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13
Jianzhang Yang, Yu Chang, Jean Ching-Yi Tien, Zhen Wang, Yang Zhou, Pujuan Zhang, Weixue Huang, Josh Vo, Ingrid J. Apel, Cynthia Wang, Victoria Zhixuan Zeng, Yunhui Cheng, George Xiaoju Wang, Arul M. Chinnaiyan, Ke Ding
JOURNAL OF MEDICINAL CHEMISTRY (2022)
Selective targeting of Aurora kinase B over A: Uncovering the structural basis for inhibitor specificity through molecular dynamics simulations
Dong Zhao, Antal H. Kovacs, Michael Campbell, Wely Floriano, Jinqiang Hou
JOURNAL OF MOLECULAR STRUCTURE (2023)
Discovery of YS-363 as a highly potent, selective, and orally efficacious EGFR inhibitor
Pengxing He, Jing Jing, Linna Du, Xuyang Zhang, Yufei Ren, Han Yang, Bin Yu, Hongmin Liu
BIOMEDICINE & PHARMACOTHERAPY (2023)
Discovery of a novel Aurora B inhibitor GSK650394 with potent anticancer and anti-aspergillus fumigatus dual efficacies in vitro
Yuhua He, Wei Fu, Liyang Du, Huiqiao Yao, Zhengkang Hua, Jinyu Li, Zhonghui Lin
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2022)
Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors
Xiaofei Liang, Chun Wang, Beilei Wang, Juan Liu, Shuang Qi, Aoli Wang, Qingwang Liu, Maoqing Deng, Li Wang, Jing Liu, Qingsong Liu
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Discovery of AS-1763: A Potent, Selective, Noncovalent, and Orally Available Inhibitor of Bruton's Tyrosine Kinase
Wataru Kawahata, Tokiko Asami, Takao Kiyoi, Takayuki Irie, Shigeki Kashimoto, Hatsuo Furuichi, Masaaki Sawa
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers
Peng Zhao, Linghang Zhuang, Xiangzhu Wang, Song Huang, Heping Wu, Yu Zhou, Yuna Yan, Fan Zhang, Ru Shen, Jing Li, Suxing Liu, Rumin Zhang, Ping Dong, Yuchang Mao, Yuanmin Fan, Chunyong He, Jiakang Sun, Lei Zhang, Qiyue Hu, Hong Wan, Jun Feng, Chang Bai, Feng He, Weikang Tao
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Discovery of potent and selective reversible Bruton?s tyrosine kinase inhibitors
Hui Qiu, Zahid Ali, Andrew Bender, Richard Caldwell, Yi-Ying Chen, Zhizhou Fang, Anna Gardberg, Nina Glaser, Anja Goettsche, Andreas Goutopoulos, Roland Grenningloh, Bettina Hanschke, Jared Head, Theresa Johnson, Christopher Jones, Reinaldo Jones, Shashank Kulkarni, Christine Maurer, Federica Morandi, Constantin Neagu, Sven Poetzsch, Justin Potnick, Ralf Schmidt, Katherine Roe, Ariele Viacava Follis, Carolyn Wing, Xiaohua Zhu, Brian Sherer
BIOORGANIC & MEDICINAL CHEMISTRY (2021)
Discovery of selective irreversible inhibitors of B-Lymphoid tyrosine kinase (BLK)
Tiancheng Fu, Yingying Zuo, Zhenpeng Zhong, Xuan Chen, Zhengying Pan
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Design and synthesis of new quinoline derivatives as selective C-RAF kinase inhibitors with potent anticancer activity
Seyed-Omar Zaraei, Nour N. Al-Ach, Hanan S. Anbar, Randa El-Gamal, Hamadeh Tarazi, Rimas T. Tokatly, Rawan R. Kalla, Mouna A. Munther, Marwa M. Wahba, Aya M. Alshihabi, Mahmoud K. Shehata, Rawan M. Sbenati, Afnan I. Shahin, Raafat El-Awady, Taleb H. Al-Tel, Mohammed I. El-Gamal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy
Naga Rajiv Lakkaniga, Zhengyu Wang, Yao Xiao, Anupreet Kharbanda, Li Lan, Hong-yu Li
MEDICINAL RESEARCH REVIEWS (2023)
Design and discovery of new selective and potent VEGF receptor 2 tyrosine kinase inhibitors
Fei Hou, Yuhong Yao, Yujiao Wei, Yubo Wang, Yangzi Cao, Xinqiang Liu, Liting Zheng, Qingqing Zhang, Yue Jiao, Yukun Chen, Yue Meng, Yue Sun, Yanjie Wu, Jiefu Wang, Junfeng Wang, Zhou Wu, Kun Zhang, Mingming Wei, Guang Yang
BIOORGANIC & MEDICINAL CHEMISTRY (2023)
Discovery of a potent, selective, and covalent ZAP-70 kinase inhibitor
Danni Rao, Heng Li, Xuelian Ren, Yaoliang Sun, Cuiyun Wen, Mingyue Zheng, He Huang, Wei Tang, Shilin Xu
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Overexpression of human ATP-binding cassette transporter ABCG2 contributes to reducing the cytotoxicity of GSK1070916 in cancer cells
Zhuo-Xun Wu, Qiuyan Mai, Yuqi Yang, Jing-Quan Wang, Hansu Ma, Leli Zeng, Zhe-Sheng Chen, Yihang Pan
BIOMEDICINE & PHARMACOTHERAPY (2021)
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification
Carrow I. Wells, Hassan Al-Ali, David M. Andrews, Christopher R. M. Asquith, Alison D. Axtman, Ivan Dikic, Daniel Ebner, Peter Ettmayer, Christian Fischer, Mathias Frederiksen, Robert E. Futrell, Nathanael S. Gray, Stephanie B. Hatch, Stefan Knapp, Ulrich Luecking, Michael Michaelides, Caitlin E. Mills, Susanne Mueller, Dafydd Owen, Alfredo Picado, Kumar S. Saikatendu, Martin Schroeder, Alexandra Stolz, Mariana Tellechea, Brandon J. Turunen, Santiago Vilar, Jinhua Wang, William J. Zuercher, Timothy M. Willson, David H. Drewry
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review
Margarite D. Matossian, Carrow I. Wells, William J. Zuercher, Bridgette M. Collins-Burow, David H. Drewry, Matthew E. Burow
CURRENT MEDICINAL CHEMISTRY (2021)
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration
David H. Drewry, Joel K. Annor-Gyamfi, Carrow Wells, Julie E. Pickett, Verena Dederer, Franziska Preuss, Sebastian Mathea, Alison D. Axtman
JOURNAL OF MEDICINAL CHEMISTRY (2022)
Design and Development of a Chemical Probe for Pseudokinase Ca2+/calmodulin-Dependent Ser/Thr Kinase
Nadine Russ, Martin Schroeder, Benedict-Tilman Berger, Sebastian Mandel, Yagmur Aydogan, Sandy Mauer, Christian Pohl, David H. Drewry, Apirat Chaikuad, Susanne Mueller, Stefan Knapp
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors
Andreas S. Kalogirou, Michael P. East, Tuomo Laitinen, Chad D. Torrice, Kaitlyn A. Maffuid, David H. Drewry, Panayiotis A. Koutentis, Gary L. Johnson, Daniel J. Crona, Christopher R. M. Asquith
MOLECULES (2021)
Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas
Deanna M. Tiek, Beril Erdogdu, Roham Razaghi, Lu Jin, Norah Sadowski, Carla Alamillo-Ferrer, J. Robert Hogg, Bassem R. Haddad, David H. Drewry, Carrow Wells, Julie E. Pickett, Xiao Song, Anshika Goenka, Bo Hu, Samuel A. Goldlust, William J. Zuercher, Mihaela Pertea, Winston Timp, Shi-Yuan Cheng, Rebecca B. Riggins
SCIENCE ADVANCES (2022)
SGC-CAMKK2-1: A Chemical Probe for CAMKK2
Carrow Wells, Yi Liang, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O'Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael M. Counago, Brittany Stork, Christopher G. Langendorf, Kevin Nay, Jonathan S. Oakhill, Debarati Mukherjee, Luigi Racioppi, Anthony R. Means, Brian York, Donald P. McDonnell, John W. Scott, Daniel E. Frigo, David H. Drewry
CELLS (2023)
A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi
Thaila Fernanda dos Reis, Patricia Alves de Castro, Rafael Wesley Bastos, Camila Figueiredo Pinzan, Pedro F. N. Souza, Suzanne Ackloo, Mohammad Anwar Hossain, David Harold Drewry, Sondus Alkhazraji, Ashraf S. Ibrahim, Hyunil Jo, Jorge D. Lightfoot, Emily M. Adams, Kevin K. Fuller, William F. deGrado, Gustavo H. Goldman
NATURE COMMUNICATIONS (2023)
Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis
Frances M. M. Bashore, Ariana B. B. Marquez, Apirat Chaikuad, Stefanie Howell, Andrea S. S. Dunn, Alvaro A. A. Beltran, Jeffery L. L. Smith, David H. H. Drewry, Adriana S. S. Beltran, Alison D. D. Axtman
SCIENTIFIC REPORTS (2023)
NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types
Khoa Nguyen, Julia Boehling, Minh N. Tran, Thomas Cheng, Andrew Rivera, Bridgette M. Collins-Burow, Sean B. Lee, David H. Drewry, Matthew E. Burow
CANCERS (2023)
Targeting the Divergent Roles of STK3 Inhibits Breast Cancer Cell Growth and Opposes Doxorubicin-Induced Cardiotoxicity In Vitro
Jiung Nam, Amelia U. Schirmer, Chelsea Loh, David H. Drewry, Everardo Macias
CANCERS (2023)
How many kinases are druggable? A review of our current understanding
Brian Anderson, Peter Rosston, Han Wee Ong, Mohammad Anwar Hossain, Zachary W. Davis-Gilbert, David H. Drewry
BIOCHEMICAL JOURNAL (2023)
Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses
David H. Drewry, Frances M. Potjewyd, Armin Bayati, Jeffery L. Smith, Rebekah J. Dickmander, Stefanie Howell, Sharon Taft-Benz, Sophia M. Min, Mohammad Anwar Hossain, Mark Heise, Peter S. McPherson, Nathaniel J. Moorman, Alison D. Axtman
JOURNAL OF MEDICINAL CHEMISTRY (2022)
Development of a potent and selective chemical probe for the pleiotropic kinase CK2
Carrow Wells, David H. Drewry, Julie E. Pickett, Amelie Tjaden, Andreas Kraemer, Susanne Mueller, Laszlo Gyenis, Daniel Menyhart, David W. Litchfield, Stefan Knapp, Alison D. Axtman
CELL CHEMICAL BIOLOGY (2021)
Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of beta-Coronaviruses
David H. Drewry, Frances M. Potjewyd, Armin Bayati, Jeffery L. Smith, Rebekah J. Dickmander, Stefanie Howell, Sharon Taft-Benz, Sophia M. Min, Mohammad Anwar Hossain, Mark Heise, Peter S. McPherson, Nathaniel J. Moorman, Alison D. Axtman
JOURNAL OF MEDICINAL CHEMISTRY (2022)