期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 53, 期 19, 页码 7129-7139出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm100832d
关键词
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A novel series of 1,2,4-triazol-3-yl-azabicyclo[3.1.0]hexanes with high affinity and selectivity for the DA D-3 receptor and excellent pharmacokinetic profiles was recently reported. We also recently discussed the role of the linker associated with the triazole moiety. In this manuscript, we are reporting a detailed exploration of the region of the receptor interacting with the amine terminus of the scaffold wherein SAR and developability data associated with these novel templates was undertaken.
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