Article
Immunology
Evangelos Papathanasiou, Andrew R. Scott, Carroll Ann Trotman, Corinna Beale, Lori Lyn Price, Gordon S. Huggins, Yang Zhang, Irene Georgakoudi, Thomas E. Van Dyke
Summary: This preclinical experimental study evaluated the impact of the methyl-ester of pro-resolving lipid mediator lipoxin A(4) (LXA(4)-ME) on scarring in a novel rabbit model of cleft lip repair. The results showed that LXA(4)-ME can reduce inflammation, decrease scar formation, and improve wound healing outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Suphachai Charoensin, Wajaree Weera
Summary: The study demonstrates that nuciferine has the potential to prevent stress-induced senescence in dermal fibroblasts by reducing the senescent phenotype and inhibiting the expression of pro-inflammatory cytokines and cell cycle regulators.
Article
Medicine, Research & Experimental
Vitor C. M. Neves, Luciana Satie Okajima, Eyad Elbahtety, Susan Joseph, James Daly, Athul Menon, Di Fan, Ayste Volkyte, Giuseppe Mainas, Kathy Fung, Pawan Dhami, Andre A. Pelegrine, Paul Sharpe, Luigi Nibali, Mark Ide
Summary: This is the first study to demonstrate that systemic interventions using Metformin in non-diabetic individuals aimed at PD prevention have oral-systemic effects.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Anne Helene Kostner, Anniken Jorlo Fuglestad, Jeanette Baehr Georgsen, Patricia Switten Nielsen, Kristina Bang Christensen, Helle Zibrandtsen, Erik Thorlund Parner, Ibraheem M. Rajab, Lawrence A. Potempa, Torben Steiniche, Christian Kersten
Summary: This study found that the acute phase reactant C-reactive protein (CRP), which can be diagnostically measured by serum levels, is correlated with poor outcomes in different types of cancer. Specifically, high levels of CRP are associated with the pro-inflammatory monomeric isoform of CRP (mCRP) within the tumor microenvironment (TME) in colon cancer patients. These findings shed light on the potential role of CRP in tumor biology.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Keila Lopes Mendes, Deborah de Farias Lelis, Daniela Fernanda de Freitas, Luiz Henrique da Silveira, Alfredo Mauricio Batista de Paula, Andre Luiz Sena Guimaraes, Janaina Ribeiro Oliveira, Marileia Chaves Andrade, Sergio Avelino Mota Nobre, Sergio Henrique Sousa Santos
Summary: The study demonstrated that the combination of resveratrol and Lactococcus lactis can reduce body weight, improve lipid metabolism, and decrease the expression of inflammatory markers, showing potential in preventing the development of liver diseases.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Microbiology
E. Mendes, M. B. Casaro, C. Fukumori, W. R. Ribeiro, A. L. dos Santos, P. Sartorelli, M. Lazarini, C. S. B. Bogsan, M. A. Oliveira, C. M. Ferreira
Summary: The study demonstrates that preventive use of probiotic kefir can reduce the influx of inflammatory cells in the airways caused by asthma, enhance mucus and interleukin 13 cytokine production, and alter macrophage polarization by decreasing the number of M2 macrophages. This potentially prevents allergic airway inflammation exacerbations in ovariectomised mice.
BENEFICIAL MICROBES
(2021)
Article
Clinical Neurology
Megan L. Falsetta, Ronald W. Wood, Mitchell A. Linder, Adrienne D. Bonham, Kenneth Honn, Krishna Rao Maddipati, Richard P. Phipps, Constantine G. Haidaris, David C. Foster
Summary: Localized provoked vulvodynia (LPV) is the most common cause of chronic dyspareunia in premenopausal women, characterized by pain with light touch to the vulvar vestibule. Specialized pro-resolving mediators (SPMs) and their precursors show promise as safe and efficacious treatment options for LPV.
Article
Cell Biology
Julia Arebro, Rebecca Towle, Che-Min Lee, Kevin L. Bennewith, Cathie Garnis
Summary: Oral squamous cell carcinoma-derived extracellular vesicles (EVs) have the ability to activate fibroblasts into cancer-associated fibroblasts (CAFs). These EV-activated CAFs have unique properties different from TGF-beta-activated CAFs. Understanding the interplay between EVs and stromal cells like CAFs could provide further insights into oral squamous cell carcinoma tumorigenesis and potential novel therapeutics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Medicine, General & Internal
Layla Panahipour, Azarakhsh Oladzad Abbasabadi, Reinhard Gruber
Summary: Necrotic cell damage resulting from invasive dental procedures leads to the release of cytoplasmic and membranous components, triggering a response in macrophages. This study tested the potential of necrotic cell lysates from different cell lines to modulate the inflammatory response in macrophages. The results showed that all necrotic cell lysates reduced the expression of IL1 and IL6 in LPS-induced macrophages, supporting the concept that necrotic cell lysates can modulate macrophage inflammation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Anne Breitruck, Markus Weigel, Jacqueline Hofrichter, Kai Sempert, Claus Kerkhoff, Nooshin Mohebali, Steffen Mitzner, Torsten Hain, Bernd Kreikemeyer
Summary: The study found that prophylactic treatment with diosmectite can effectively alleviate the severity of DSS colitis, demonstrated by reduced weight loss, disease activity index, and histological damage score. However, diosmectite treatment did not have a significant impact on the expression of tight junction proteins. Additionally, the treatment altered the microbial composition associated with DSS, showing potential as a therapeutic approach for intestinal inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Corinna L. L. Seidel, Elena Percivalle, Marco Tschaftari, Matthias Weider, Karin Strobel, Ines Willershausen, Christoph Unertl, Helga M. M. Schmetzer, Manuel Weber, Michael Schneider, Benjamin Frey, Udo S. S. Gaipl, Matthias W. W. Beckmann, Lina Goelz
Summary: The study found significantly increased levels of oral cytokines in neonates with orofacial clefts, especially at the first consultation after birth. Furthermore, a significant positive correlation was detected between cleft severity and specific pro-inflammatory mediators.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
James Varani, Shannon D. McClintock, Daniyal M. Nadeem, Isabelle Harber, Dania Zeidan, Muhammad N. Aslam
Summary: This study investigates the effects of a red algae-derived multimineral intervention on barrier proteomic expression in ulcerative colitis. The results suggest that the intervention improves barrier structure/function and reduces the expression of pro-inflammatory proteins. This highlights the potential of the intervention as a novel approach for combating inflammation in the colon.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jamie M. L. Kok, Georgina C. Dowd, Jaydee D. Cabral, Lyn M. Wise
Summary: A lipid extract from Macrocystis pyrifera has anti-inflammatory and barrier-protective effects on keratinocytes, suggesting its potential benefits in the treatment of atopic dermatitis or other skin conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Ying Zhou, Mei Yang, Xiangji Yan, Lingmin Zhang, Ning Lu, Yana Ma, Yuanyuan Zhang, Manli Cui, Mingzhen Zhang, Mingxin Zhang
Summary: Ulcerativecolitis (UC), an inflammatory bowel disease, lacks effective therapies. This study developed a nanocarrier called AG/CORM-2@NP-Dex, which efficiently delivered the anti-inflammatory compound AG and CO donor CORM-2. The nanocarrier demonstrated anti-inflammatory and pro-resolving effects, making it a promising therapeutic approach for UC.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Maha Jameal Balgoon, Maryam H. Al-Zahrani, Soad Al Jaouni, Nasra Ayuob
Summary: The combined topical and oral application of pumpkin extract (PE) significantly reduced inflammatory and oxidative changes induced by contact dermatitis and depression compared to standard treatment, mainly through downregulation of pro-inflammatory cytokines and upregulation of antioxidants.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rocio Garcia-Villalba, Francisco A. Tomas-Barberan, Carlos E. Iglesias-Aguirre, Juan Antonio Gimenez-Bastida, Antonio Gonzalez-Sarrias, Maria Victoria Selma, Juan Carlos Espin
Summary: Ellagitannins (ETs) and ellagic acid (EA) are dietary polyphenols metabolized by gut microbiota to produce urolithins (Uros), which have potential health benefits. Consuming ET-rich foods, such as pomegranate, may improve brain health. However, the specific mechanism and metabolites responsible for these effects are still unknown. Uro-A, a metabolite of ETs, shows potential in neuroprotection through anti-inflammatory, mitophagy, autophagy, and mitochondrial biogenesis activities. Improving blood flow, gut microbiota ecology, and gut barrier integrity may also contribute to the neuroprotective effects. This article reviews the current evidence and proposes a roadmap for further research in this area.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Review
Cell Biology
Hatim Boughanem, Yvonne Bottcher, Joao Tome-Carneiro, Maria-Carmen Lopez de Las Hazas, Alberto Davalos, Akin Cayir, Manuel Macias-Gonzalez
Summary: Mitochondrial epitranscriptomics refers to modifications occurring in various types of RNA within mitochondria. These modifications play a critical role in accurate protein synthesis and have implications in mitochondrial-related diseases. Research has focused on mutations in mitochondrial and nuclear DNA genes encoding enzymes involved in these modifications. This article reviews current evidence on mitochondrial RNA modifications and their role in metabolic disorders, and explores the potential of using them as targets for prevention and early detection.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Agriculture, Multidisciplinary
Ana M. Ares, Laura Toribio, Rocio Garcia-Villalba, Jose M. Villalgordo, Yusuf Althobaiti, Francisco A. Tomas-Barberan, Jose Bernal
Summary: Urolithins are metabolites produced in humans after consuming foods with ellagitannins and ellagic acid. This study reports a novel method for separating different isomers of urolithin glucuronides using supercritical fluid chromatography. The proposed method successfully analyzed these metabolites in urine samples from volunteers of different metabotypes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Gabriela L. Salazar-Orbea, Rocio Garcia-Villalba, Maria J. Bernal, Alberto Hernandez-Jimenez, Jose A. Egea, Francisco A. Tomas-Barberan, Luis M. Sanchez-Siles
Summary: This research examined the impact of different storage conditions on the bioactive phenolic compounds, color, and sensory attributes of strawberry and apple purees produced with various industrial technologies. The study found that storage conditions had a stronger influence on phenolic compound levels in strawberry puree, particularly anthocyanins, while the initial processing techniques of apple puree had a greater impact than storage conditions. Proanthocyanidins were the most stable phenolic group during storage, while anthocyanins were the most affected. The stability of polyphenols varied between fruits during storage, and both processing and storage could have detrimental or beneficial effects.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ana Pozo-Rodriguez, Juan A. A. Mendez-Liter, Rocio Garcia-Villalba, David Beltran, Eva Calvino, Andres G. Santana, Laura I. I. De Eugenio, Francisco Javier Canada, Alicia Prieto, Jorge Barriuso, Francisco A. A. Tomas-Barberan, Maria Jesus Martinez
Summary: Resveratrol was glycosylated by using rXynSOS-E236G glycosynthase, resulting in the production of 3-O-beta-D-xylobiosyl resveratrol as the major product. Response surface methodology was used to optimize the reaction, yielding 35% of 3-O-beta-D-xylobiosyl resveratrol. Xylobiosylation decreased the antioxidant capacity of resveratrol, but significantly improved its solubility for improved delivery and transit to the colon.
Article
Agriculture, Multidisciplinary
Carlos E. Iglesias-Aguirre, Rocio Garcia-Villalba, David Beltran, Maria Dolores Frutos-Lison, Juan C. Espin, Francisco A. Tomas-Barberan, Maria V. Selma
Summary: We discovered a new bacterium in the feces of a healthy woman that can produce urolithins A and B as well as intermediate metabolites. Additionally, we developed co-culture systems that reproduced the production of urolithins upon fermentation of UM-A and UM-B. This finding demonstrates the potential of these urolithin-producing bacteria for use as probiotics and in the production of bioactive urolithins for various applications.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
David Beltran, Maria D. Frutos-Lison, Rocio Garcia-Villalba, Jose E. Yuste, Victor Garcia, Juan C. Espin, Maria V. Selma, Francisco A. Tomas-Barberan
Summary: A novel urolithin G was identified and characterized from urolithin D by in vitro incubation with different human gut Enterocloster species. Urolithin G was found in the feces of overweight and obese volunteers after consuming an ellagitannin-rich pomegranate extract. The production of urolithin G required a bacterial 9-dehydroxylase activity and was not specific to the known human urolithin metabotypes A and B.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Carlos E. Iglesias-Aguirre, Antonio Gonzalez-Sarrias, Adrian Cortes-Martin, Maria Romo-Vaquero, Leire Osuna-Galisteo, Jose Joaquin Ceron, Juan Carlos Espin, Maria Victoria Selma
Summary: The capacity to produce urolithin varies among individuals due to differences in gut bacterial ecology. In this study, two urolithin-producing bacterial consortia were administered to rats, successfully colonizing their guts and transferring the ability to produce urolithins. The bacterial strains were well-tolerated and did not have adverse effects on gut bacteria, blood parameters, or biochemical parameters, making them potential probiotics for individuals who cannot produce bioactive urolithins.
Article
Agriculture, Multidisciplinary
Gabriela L. Salazar-Orbea, Rocio Garcia-Villalba, Maria J. Bernal, Alberto Hernandez-Jimenez, Jose A. Egea, Francisco A. Tomas-Barberan, Luis M. Sanchez-Siles
Summary: This research focused on how storage conditions and processing techniques affect the composition of nutrients, bioactive compounds, and sensory attributes in strawberry and apple purees. The study found that storage conditions had a stronger impact on phenolic compounds in strawberry puree, while initial processing techniques had a greater influence on apple puree. The stability of polyphenols varied between fruits during storage, and selecting the optimal storage conditions is crucial for maintaining the polyphenol content in sensitive fruits like strawberries.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Juan Antonio Gimenez-Bastida, Maria angeles Avila-Galvez, Alicia Martinez-Lopez, Diana Garcia-Moreno, Juan Carlos Espin, Antonio Gonzalez-Sarrias
Summary: Current research indicates that consuming food rich in isoflavones is beneficial for cardiovascular health. This study investigates the antiangiogenic activities of the main circulating isoflavone metabolites and finds that certain metabolites may play a role in cardiovascular health.
Article
Food Science & Technology
Maria V. Calvo, Viviana Loria Kohen, Carmen Diaz-Mardomingo, Sara Garcia-Herranz, Shishir Baliyan, Joao Tome-Carneiro, Gonzalo Colmenarejo, Francesco Visioli, Cesar Venero, Javier Fontecha
Summary: Cognitive decline is a significant consequence of aging, and pharmacological therapies have not been effective. The use of a milk drink fortified with MFGM as a dietary supplement may improve cognitive function, particularly in women.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Maria-Carmen Lopez de las Hazas, Andrea del Saz-Lara, Lidia Cedo, Maria Carmen Crespo, Joao Tome-Carneiro, Luis A. Chapado, Alba Macia, Francesco Visioli, Joan C. Escola-Gil, Alberto Davalos
Summary: HT supplementation in humanized mice resulted in systemic dyslipidemia, impaired glucose metabolism, increased body weight, and accumulation of triacylglycerols in different tissues. The expression of genes related to lipid metabolism, such as Pltp or Lpl, was also modulated by HT. Further studies are needed to fully understand the potential effects of HT consumption.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)