期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 53, 期 6, 页码 2521-2527出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm901674f
关键词
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Novel 5-cyclic amine-3-arylsulfonylindazoles were prepared, and several analogues within this class have been identified as high-affinity 5-HT6 receptor ligands with improved pharmacokinetic and pharmacological properties. One selected example, 18b, showed good brain penetrability and a generally favorable pharmacokinetic profile with procognitive efficacy in the rat novel object recognition assay. The synthesis and structure activity relationship of this potent class are discussed.
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