Review
Chemistry, Multidisciplinary
Hongtong Chen, Chengqi Yu, Han Wu, Guoqing Li, Congran Li, Wei Hong, Xinyi Yang, Hao Wang, Xuefu You
Summary: The prevalence of antimicrobial-resistant pathogens poses a challenge to clinical practice, necessitating the discovery of new antibacterial drugs. One potential target is the histidine kinase (HK) in the two-component system (TCS) of bacteria. This review highlights the structural basis and functional importance of HKs as a target in the development of novel antimicrobials, and summarizes the latest research progress in small-molecule HK inhibitors as potential antimicrobial drugs.
FRONTIERS IN CHEMISTRY
(2022)
Article
Microbiology
Yanjie Liu, Yushi Fu, Mengkai Zhou, Xiaoran Hao, Ping Zhang, Xudong Zhu
Summary: The transcription factor DibT plays a key role in the expression of the pks8 gene cluster in the endophytic fungus Pestalotiopsis microspora and has a wide effect on the expression of PKS genes in the genome. This study provides information for the regulation of dibenzodioxocinone biosynthesis and may be helpful for the development of new CETP inhibitors.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ana I. Ahuja-Casarin, Penelope Merino-Montiel, Jose Luis Vega-Baez, Sara Montiel-Smith, Miguel X. Fernandes, Irene Lagunes, Ines Maya, Jose M. Padron, Oscar Lopez, Jose G. Fernandez-Bolanos
Summary: Novel cholinesterase inhibitors based on 1-deoxynojirimycin were designed for potential anti-Alzheimer's therapy, with good selectivity towards BuChE and strong mixed inhibition effects. Lead compounds showed interactions with the catalytic and anionic sites of cholinesterase through H-bonds and van der Waals forces, while lacking significant antiproliferative activity against tumor and non-tumor cells at 100 μM.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Review
Food Science & Technology
Yessica Enciso-Martinez, Gustavo A. Gonzalez-Aguilar, Miguel A. Martinez-Tellez, Cristobal J. Gonzalez-Perez, Dora E. Valencia-Rivera, Edwin Barrios-Villa, Jesus Fernando Ayala-Zavala
Summary: This article introduces the evolution, classification, and the effects of Escherichia coli on the host. It is found that E. coli includes pathobiont strains that infect the host through toxin production, adherence effects, and tissue damage. Environmental stresses and bacterial exposure to antibiotics and disinfectants contribute to their evolution. Therefore, researchers are exploring new antibacterial and antivirulence agents, mainly from natural sources.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dirong Wu, Jiao Chen, Keke Luo, Hui Li, Ting Liu, Li Li, Zeqin Dai, Yongjun Li, Yonglong Zhao, Xiaozhong Fu
Summary: In this study, a series of scutellarin derivatives were designed, synthesized, and evaluated as multifunctional therapeutic agents for Alzheimer's disease. One of the compounds, 6h, showed potent inhibition of acetyl cholinesterase and Aβ aggregation, as well as neuroprotective effects and optimal blood-brain barrier and intestinal absorption characteristics. The in vivo experiments further demonstrated its potential in improving learning and memory impairment. These findings highlight compound 6h as a promising multifunctional drug candidate against Alzheimer's disease.
BIOORGANIC CHEMISTRY
(2022)
Article
Microbiology
Sabrina Muehlen, Viktor A. Zapol'skii, Ursula Bilitewski, Petra Dersch
Summary: The inhibition of T3SS-mediated effector translocation could be crucial for reducing EPEC and enterohemorrhagic E. coli infections, as it reduces bacterial binding to host cells, effector-induced cell detachment, and abolishes attaching and effacing lesion formation without affecting the expression of components associated with T3SS or effector proteins.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Kishanpal Singh, Neetu Singh, Harvinder Singh Sohal, Baljit Singh, Fohad Mabood Husain, Mohammed Arshad, Mohd Adil
Summary: This study reports a synthetic route for generating N-phenyl amino acid derivatives using CO(2) through a C-C coupling reaction in an undivided cell with Mg-Pt electrodes. The synthesis is efficient, simple, and produces no side products. The newly prepared compounds' structures were determined using advanced spectroscopic techniques. The derivatives exhibited good to excellent activity against bacterial and fungal strains. Interestingly, compounds with polar groups capable of forming hydrogen bonds showed activity equivalent to standard drugs.
Article
Agronomy
Lili Wang, Zuobin Ma, Houxiang Kang, Shuang Gu, Zhanna Mukhina, Changhua Wang, Hui Wang, Yuanjun Bai, Guomin Sui, Wenjing Zheng, Dianrong Ma
Summary: Pi65, a novel rice blast disease resistance gene, was cloned from Oryza sativa japonica and can enhance rice blast resistance through genetic engineering. The protein encoded by Pi65 has specific domains that can recognize and resist rice blast fungus. After pathogen infection, Pi65 activates numerous disease resistance-related genes while simultaneously suppressing photosynthesis and carbohydrate metabolism-related genes.
THEORETICAL AND APPLIED GENETICS
(2022)
Article
Chemistry, Multidisciplinary
Khushbu Rajput, Vishal Singh, Arsala Kamal, Himanshu Kumar Singh, Sundaram Singh, Vandana Srivastava
Summary: A novel metal-free and environment-friendly approach using photoredox catalyst Eosin Y, ethanol:water as a green solvent, and atmospheric air as an oxidant has been developed for synthesizing biologically important moieties, benzothiazoles and benzimidazoles. This method offers good to excellent yields and has several advantages including low cost, environmental friendliness, non-toxicity, ease of handling, and the use of renewable energy sources such as visible light.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Immunology
Erika Kushikawa Saeki, Amanda Yaeko Yamada, Larissa Amianti de Araujo, Lais Anversa, Doroti de Oliveira Garcia, Renan Luiz Barros de Souza, Heloisa Moreira Martins, Renata Katsuko Takayama Kobayashi, Gerson Nakazato
Summary: This study investigated the effects of subinhibitory concentrations of biogenic silver nanoparticles on motility and biofilm formation in P. aeruginosa. Results showed that subinhibitory concentrations of bio-AgNPs increased motility and enhanced biofilm formation capacity in certain P. aeruginosa isolates. Further research is needed to explore the impact of AgNPs on P. aeruginosa quorum sensing at subinhibitory concentrations.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Patricia Alves de Castro, Clara Valero, Jessica Chiaratto, Ana Cristina Colabardini, Lakhansing Pardeshi, Lilian Pereira Silva, Fausto Almeida, Marina Campos Rocha, Roberto Nascimento Silva, Iran Malavazi, Wenyue Du, Paul S. Dyer, Matthias Brock, Flavio Vieira Loures, Koon Ho Wong, Gustavo H. Goldman
Summary: The study revealed the crucial role of the NsdC transcription factor in Aspergillus fumigatus, not only in sexual reproduction and growth regulation, but also in response to calcium stress, cell wall organization, virulence, and host immune recognition. The deletion of nsdC resulted in changes in expression of over 620 genes, indicating its involvement in multiple signaling and metabolic pathways beyond its initially known functions.
Review
Chemistry, Multidisciplinary
Oana Sandulescu, Ioana Viziteu, Anca Streinu-Cercel, Victor Daniel Miron, Liliana Lucia Preotescu, Narcis Chirca, Simona Elena Albu, Mihai Craiu, Adrian Streinu-Cercel
Summary: In this paper, the recent progress in fighting antimicrobial resistance, especially in relation to WHO's priority pathogens, is characterized. The focus is on novel antimicrobials, drug delivery systems for targeted antimicrobial action, and novel antivirulence targets. The findings suggest a limited number of clinical trials targeting WHO's priority 1 pathogens, with various promising advancements in drug delivery systems and antivirulence therapeutics.
APPLIED SCIENCES-BASEL
(2022)
Article
Multidisciplinary Sciences
Pulak Kar, Yu-Ping Lin, Rajesh Bhardwaj, Charles J. Tucker, Gary S. Bird, Matthias A. Hediger, Carina Monico, Nader Amin, Anant B. Parekh
Summary: Eukaryotic cells confine second messengers to spatially restricted subcompartments to avoid conflicting outcomes. The smallest signaling unit, Ca2+ nanodomain, is formed when Ca2+ channels open. NFAT1 tethered to scaffolding protein AKAP79 is activated by local Ca2+ entry, providing a mechanism to selectively recruit a transcription factor.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Rheumatology
Lars Erik Kristensen, Silvio Danese, Arne Yndestad, Cunshan Wang, Edward Nagy, Irene Modesto, Jose Rivas, Birgitta Benda
Summary: Based on primary results from ORAL Surveillance, this study identified two subpopulations of patients treated with tofacitinib who had different relative risks compared to TNFi. Older age and smoking were identified as risk factors associated with increased risk, while younger age and non-smoking were associated with no detectable risk increase. These findings have important implications for individualized treatment decisions with tofacitinib.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Andra-Rodica Balanescu, Gustavo Citera, Virginia Pascual-Ramos, Deepak L. Bhatt, Carol A. Connell, David Gold, All-Shine Chen, Gosford Sawyerr, Andrea B. Shapiro, Janet E. Pope, Hendrik Schulze-Koops
Summary: This study aimed to characterize infections in patients with rheumatoid arthritis (RA) receiving different treatment regimens. The results showed that tofacitinib had a higher risk of infections compared to tumor necrosis factor inhibitors (TNFi). These findings may provide insights for future treatment decisions.
ANNALS OF THE RHEUMATIC DISEASES
(2022)