期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 52, 期 21, 页码 6519-6522出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm9012856
关键词
-
资金
- National Institutes Of Health [CA 101880]
Cationic gold(I) complexes containing 1-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea (1), [AuL(1)](n+) (where L is Cl-, Br-, SCN-, PEt3, PPh3, or 1), derived from a class of analogous platinum(II) antitumor agents, have been synthesized. Unlike platinum, gold does not form permanent adducts with DNA, and its complexes are 2 orders of magnitude less cytotoxic in non-small-cell lung cancer cells than the most active platinum-based agent. Instead, several gold analogues show submicromolar and selective anti microbial activity against Mycobacterium tuberculosis.
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