期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 52, 期 18, 页码 5748-5752出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm9009668
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资金
- Louisiana Cancer Research Consortium [631324]
Resistance to chemotherapy and endocrine therapy is a major cause of breast cancer treatment failure. We have synthesized six novel analogues using C8-ceramide as the lead analogue and studied their effect on hormone therapy resistant (MDA-MB-231) and chemoresistant (MCF-7TN-R) breast cancer cells. Pharmacologic intervention using these ceramide analogues inhibited clonogenic survival and induced apoptosis, with one analogue being more effective than C8-ceramide. Our results show ceramide-based therapy has therapeutic potential in treating drug resistant breast cancer.
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