4.7 Article Retracted Publication

被撤回的出版物: Antioxidant-Based Lead Discovery for Cancer Chemoprevention: The Case of Resveratrol (Retracted Article. See vol 52, pg 6504, 2009)

期刊

JOURNAL OF MEDICINAL CHEMISTRY
卷 52, 期 7, 页码 1963-1974

出版社

AMER CHEMICAL SOC
DOI: 10.1021/jm8015415

关键词

-

资金

  1. National Natural Science Foundation of China [20502010, 20621091]
  2. New Century Excellent Talents in University [NCET-06-0906]

向作者/读者索取更多资源

Resveratrol is a well-known natural antioxidant and cancer chemopreventive agent that has attracted much interest in the past decade. Resveratrol-directed compounds were synthesized, and their antioxidant effects against reactive oxygen species (ROS)-induced DNA damage, their prooxidant effects on DNA damage in the presence cupric ions, and their cytotoxic and apoptosis-inducing effects on human promyelocytic leukemia (HL-60) cells were investigated in vitro. It was found that the compounds bearing o-diphenoxyl groups exhibited remarkably higher activities in inhibiting ROS-induced DNA damage, accelerating DNA damage in the presence cupric ions, and inducing apoptosis of HL-60 cells compared with the ones bearing no such groups. The detail mechanism of the structure-activity relationship was also studied by the oxidative product analysis of resveratrol and its analogues with galvinoxyl radical or cupric ions and UV-visible spectra change in the presence cupric ions. This study reveals a good and interesting correlation between antioxidant and prooxidant activity, as well as cytotoxicity and apoptosis-inducing activity against HL-60 cells, and provides an idea for designing antioxidant-based cancer chemoprevention agents.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据