期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 51, 期 23, 页码 7344-7347出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm801241n
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- DOD [W81XWH-07-1-0445]
The first synthesis and biological evaluation of antibiotic 31 (A-33853) and its analogues are reported. Initial screening for inhibition of L. donovani, T. b. rhodesiense, T cruzi, and P. falciparum cultures followed by determination of IC50 in L. donovani and cytotoxicity on L6 cells revealed 31 to be 3-fold more active than miltefosine, a known antileishmanial drug, Compounds 14, 15, and 25 selectively inhibited L. donovani at nanomolar concentrations and showed much lower cytotoxicity.
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