Article
Veterinary Sciences
Jerrianne E. Brandly, Monica Midon, Hope F. Douglas, Klaus Hopster
Summary: This study evaluated the impact of flow-controlled expiration (FLEX) ventilation on horses undergoing anesthesia. The results showed that horses ventilated with FLEX required lower PEEP to prevent alveolar closure, and had higher cardiac output.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Physiology
Diana Jansen, Annemijn H. Jonkman, Heder J. de Vries, Myrte Wennen, Judith Elshof, Maud A. Hoofs, Marloes van den Berg, Angelique M. E. de Man, Christiaan Keijzer, Gert-Jan Scheffer, Johannes G. van der Hoeven, Armand Girbes, Pieter Roel Tuinman, J. Tim Marcus, Coen A. C. Ottenheijm, Leo Heunks
Summary: This study investigated the effects of short-term application of PEEP on diaphragm geometry and function, finding that increasing PEEP led to diaphragm displacement, muscle shortening, increased thickness, and reduced neuromechanical efficiency. These findings suggest that the conditions for developing longitudinal atrophy in the human diaphragm are present with the application of PEEP.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Critical Care Medicine
Luis Schulz, Antony Stewart, William O'Regan, Peter McCanny, Danielle Austin, Magnus Hallback, Mats Wallin, Anders Aneman
Summary: This study reveals that increased positive end-expiratory pressure (PEEP) can improve oxygenation in mechanically ventilated COVID-19 patients with respiratory failure, and this improvement is correlated with the increase in end-expiratory lung volume and pulmonary perfusion.
Article
Medicine, General & Internal
Paolo Formenti, Sara Miori, Andrea Galimberti, Michele Umbrello
Summary: This study aimed to assess the impact of different levels of positive end-expiratory pressure (PEEP) and lung inflation on diaphragm thickness, thickening fraction, and displacement. It found that higher levels of PEEP resulted in lower tidal volume, diaphragm displacement, and thickening fraction, while increasing both expiratory and inspiratory thickness. The study also showed that there was a correlation between diaphragm thickness and thickening fraction with inspiratory effort, which was stronger at lower levels of PEEP.
Article
Critical Care Medicine
Tommaso Pettenuzzo, Annalisa Boscolo, Alessandro De Cassai, Nicolo Sella, Francesco Zarantonello, Paolo Persona, Laura Pasin, Giovanni Landoni, Paolo Navalesi
Summary: The study found that for ICU patients not suffering from ARDS, the use of higher positive end-expiratory pressure (PEEP) was not significantly associated with hospital mortality compared to lower PEEP. However, it was associated with improved oxygenation, higher respiratory system compliance, and reduced risk of hypoxemia and ARDS.
Article
Health Care Sciences & Services
Fujen Wang, Indra Permana, Citra Chaerasari, Bivas Panigrahi, Dibakar Rakshit
Summary: The study investigated a negative-pressurized isolation facility in a pediatric intensive care unit, which can accommodate multiple pediatric patients with minimal design modifications. Field measurement tests and computational fluid dynamics were utilized to evaluate the ventilation performance, indicating a significant contamination control to protect medical staff and patients.
Article
Multidisciplinary Sciences
Kunming Cheng, Wanqing Li, Yanqiu Lu, Haiyang Wu, Jianxin Zhou
Summary: The aim of this study was to assess the effect of modified high-flow oxygen therapy on end-expiratory lung volume (EELV) and positive end-expiratory pressure (PEEP) in tracheotomized patients with normal pulmonary, acute hypoxic respiratory failure (AHRF) or chronic obstructive pulmonary disease (COPD). The results showed that as the flow rate increased, the PEEP values in all groups showed an exponential increasing trend, and the EELV also increased accordingly. In addition, the PEEP values of the modified high-flow oxygen therapies were significantly higher than those of the standard high-flow oxygen therapy.
Article
Veterinary Sciences
Marcela L. Machado, Joao H. N. Soares, Bruno H. Pypendop, Antonio J. A. Aguiar, Christina Braun, Gabriel C. Motta-Ribeiro, Frederico C. Jandre
Summary: In cats under anesthesia with isoflurane and mechanical ventilation for 3 hours, all levels of PEEP had mild improvements in gas exchange with higher levels causing more cardiovascular depression. Dopamine was effective in treating low blood pressure in some cases.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Medicine, Research & Experimental
Domenico Luca Grieco, Salvatore Maurizio Maggiore, Giacomo Bellani, Savino Spadaro, Elena Spinelli, Tommaso Tonetti, Luca S. Menga, Marco Pozzi, Denise Battaglini, Rosa Di Mussi, Andrea Bruni, Andrea De Gaetano, Carmine Giovanni Iovino, Matteo Brioni, Francesco Mojoli, Giuseppe Foti, Carlo Aberto Volta, Paolo Pelosi, Paolo Navalesi, Salvatore Grasso, V. Marco Ranieri, Massimo Antonelli
Summary: The IPERPEEP trial aims to investigate whether an individualized PEEP setting protocol based on bedside assessment of lung recruitability can improve a composite clinical outcome in patients with moderate-to-severe ARDS.
Article
Pediatrics
Mukesh Kumar Jain, Sibabratta Patnaik, Bandya Sahoo, Reshmi Mishra, Jyoti Ranjan Behera
Summary: This study evaluated the indications, timing, complications, and outcomes of tracheostomy in children, finding that prolonged mechanical ventilation is the most common indication, with some patients experiencing complications post-operatively. However, the majority of patients were successfully discharged, and tracheostomy did not directly result in mortality.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Xin-yu Gan, Jun Zhang, Ping Xu, Si-jin Liu, Zhi-lin Guo
Summary: Early passive orthostatic training can prevent diaphragm atrophy and dysfunction in ICU patients on mechanical ventilation.
Review
Medicine, General & Internal
Pule Li, Xia Kang, Mengrong Miao, Jiaqiang Zhang
Summary: Individualized PEEP setting during one-lung ventilation can reduce postoperative pulmonary complications and improve perioperative oxygenation in patients undergoing thoracic surgery.
Article
Critical Care Medicine
Alessandro Protti, Alessandro Santini, Francesca Pennati, Chiara Chiurazzi, Massimo Cressoni, Michele Ferrari, Giacomo E. Iapichino, Luca Carenzo, Ezio Lanza, Giorgio Picardo, Pietro Caironi, Andrea Aliverti, Maurizio Cecconi
Summary: Patients with early ARDS due to COVID-19 have a large potential for lung recruitment, but their compliance and Pa-CO2 may not improve with higher PEEP, possibly due to hyperinflation.
Article
Biophysics
Tobias Hoehne, Christin Wenzel, Stefan Schumann
Summary: The study demonstrated that the homogenizing effects of FLEX on compartmental pressure distribution can be effective, especially in a simulated chest wall compliance setting. This mechanism may contribute to the lung protective effects of ventilation with FLEX.
PHYSIOLOGICAL MEASUREMENT
(2021)
Article
Physiology
Alberto Giardina, Danilo Cardim, Pietro Ciliberti, Denise Battaglini, Lorenzo Ball, Magdalena Kasprowicz, Erta Beqiri, Peter Smielewski, Marek Czosnyka, Shirin Frisvold, Matjaz Groznik, Paolo Pelosi, Chiara Robba
Summary: This study aims to assess the effect of increasing positive end-expiratory pressure (PEEP) on cerebral autoregulation in brain injured patients. The results showed that increasing PEEP did not worsen cerebral autoregulation and did not require clinical intervention.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Critical Care Medicine
Christophe Milesi, Sandrine Essouri, Robin Pouyau, Jean-Michel Liet, Mickael Afanetti, Aurelie Portefaix, Julien Baleine, Sabine Durand, Clementine Combes, Aymeric Douillard, Gilles Cambonie
INTENSIVE CARE MEDICINE
(2017)
Article
Pediatrics
Sandrine Essouri, Florent Baudin, Laurent Chevret, Melanie Vincent, Guillaume Emeriaud, Philippe Jouvet
JOURNAL OF PEDIATRICS
(2017)
Article
Infectious Diseases
Caroline Charlier, Elodie Perrodeau, Alexandre Leclercq, Benoit Cazenave, Benoit Pilmis, Benoit Henry, Amanda Lopes, Mylene M. Maury, Alexandra Moura, Francois Goffinet, Helene Bracq Dieye, Pierre Thouvenot, Marie-Noelle Ungeheuer, Mathieu Tourdjman, Veronique Goulet, Henriette de Valk, Olivier Lortholary, Philippe Ravaud, Marc Lecuit
LANCET INFECTIOUS DISEASES
(2017)
Article
Engineering, Biomedical
Haythem Rehouma, Rita Noumeir, Wassim Bouachir, Philippe Jouvet, Sandrine Essouri
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2018)
Article
Pediatrics
Florent Baudin, Guillaume Emeriaud, Sandrine Essouri, Jennifer Beck, Aurelie Portefaix, Etienne Javouhey, Claude Guerin
JOURNAL OF PEDIATRICS
(2019)
Article
Critical Care Medicine
Guillaume Mortamet, Nicolas Nardi, Veronique Groleau, Sandrine Essouri, Brigitte Fauroux, Philippe Jouvet, Guillaume Emeriaud
Article
Critical Care Medicine
Sandrine Essouri, Florent Baudin, Guillaume Mortamet, Jennifer Beck, Philippe Jouvet, Guillaume Emeriaud
PEDIATRIC CRITICAL CARE MEDICINE
(2019)
Article
Engineering, Electrical & Electronic
Haythem Rehouma, Rita Noumeir, Sandrine Essouri, Philippe Jouvet
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2020)
Article
Pediatrics
Pierre-Philippe Piche-Renaud, Louis-Philippe Thibault, Sandrine Essouri, Annik Chainey, Corinne Theriault, Gabrielle Bernier, Nathalie Gaucher
Summary: This study explored parents' experiences and information needs during the treatment of bronchiolitis in infants. Parents were found to be generally worried about their child's health and lacked knowledge about bronchiolitis, leading to increased anxiety. They expressed a strong desire for support and reassurance from healthcare teams, and while standardized educational tools were helpful, they fell short of meeting all needs.
Letter
Pediatrics
Pierre-Philippe Piche-Renaud, Louis-Philippe Thibault, Sandrine Essouri, Annik Chainey, Corinne Theriault, Gabrielle Bernier, Nathalie Gaucher
Review
Oncology
Simon Marcoux, Yves Theoret, Josee Dubois, Sandrine Essouri, Alix Pincivy, Jerome Coulombe, Catherine McCuaig, Julie Powell, Gilles Soulez, Niina Kleiber
Summary: Off-label drug prescribing is common in the treatment of vascular anomalies, particularly in pediatric care, but the evidence surrounding drug use in this area is generally of low quality with a predominance of retrospective studies and case reports. Drug safety is inadequately reported and there is a major publication bias leading to potential overestimation of drug efficacy in treating vascular anomalies.
PEDIATRIC BLOOD & CANCER
(2021)
Letter
Pediatrics
Pierre-Philippe Piche-Renaud, Louis-Philippe Thibault, Sandrine Essouri, Annik Chainey, Corinne Theriault, Gabrielle Bernier, Nathalie Gaucher
Article
Computer Science, Information Systems
Haythem Rehouma, Rita Noumeir, Gabriel Masson, Sandrine Essouri, Philippe Jouvet
Letter
Critical Care Medicine
Florent Baudin, Guillaume Emeriaud, Sandrine Essouri, Jennifer Beck, Etienne Javouhey, Claude Guerin
Article
Pediatrics
G. Mortamet, G. Emeriaud, P. Jouvet, B. Fauroux, S. Essouri
ARCHIVES DE PEDIATRIE
(2017)