期刊
JOURNAL OF MEDICAL VIROLOGY
卷 85, 期 2, 页码 327-335出版社
WILEY
DOI: 10.1002/jmv.23472
关键词
BKV; JCV; immunosuppression; organ transplantation; seroprevalence; serostability
类别
资金
- EC [QLK2-CT-2002-01179]
- Garnett Passe and Rodney Williams Memorial Foundation
- National Health and Medical Research Council (Australia)
- Cancer Research UK [13044] Funding Source: researchfish
The human polyomaviruses BKV and JCV cause mostly subclinical infections in childhood. Systemical immunosuppression after organ transplantation can lead to reactivation of persistent polyomavirus infections which may cause rejection of the transplanted organ. BKV and JCV seroprevalence and serostability was measured in 441 European solid organ transplanted recipients. Baseline samples were collected on average 24 days post-transplantation and sera were then collected over an 18 months follow-up period on up to six different time points. The overall seroprevalence at baseline for BKV was 97% with very little change over time. Prevalence for JCV was 76% at baseline and increased to 80% at the end of follow-up. BKV seroprevalence was highest in the youngest age group (100%) and decreased with increasing age (92% in the oldest age group; P?
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