☆ 4.7 Article

Acute West Nile Virus Neuroinvasive Infections: Cross-Reactivity With Dengue Virus and Tick-Borne Encephalitis Virus

JOURNAL OF MEDICAL VIROLOGY (2011)

期刊

JOURNAL OF MEDICAL VIROLOGY

卷 83, 期 10, 页码 1861-1865

出版社

WILEY

DOI: 10.1002/jmv.22180

关键词

West Nile virus; cross-reactivity; serology; Dengue virus; tick-borne encephalitis virus

类别

Virology

资金

Hellenic Centre for Disease Control and Prevention

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Protocol

Reagent

摘要

Cross-reactions in serology are common among flaviviruses. During the outbreak of West Nile virus (WNV) infections in Greece in 2010, WNV IgM-positive serum and cerebrospinal fluid samples were tested for the presence of IgM and IgG antibodies against Dengue virus (DENV) and tick-borne encephalitis virus. Higher cross-reactivity was observed in IgM antibodies between WNV and DENV; however, the index of the WNV antibodies was in all cases higher than that of the DENV antibodies. There is a need for caution when evaluating serologic results of flaviviral infections, while efforts have to be focused on the development of diagnostic assays with increased specificity. J. Med. Virol. 83:1861-1865, 2011. (C) 2011 Wiley-Liss, Inc.

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