☆ 4.7 Article

Young Age a Predictor of Weak Reactivity in a Rapid Antibody Test in Infants Infected With HIV

JOURNAL OF MEDICAL VIROLOGY (2010)

期刊

JOURNAL OF MEDICAL VIROLOGY

卷 82, 期 8, 页码 1314-1317

出版社

WILEY-LISS

DOI: 10.1002/jmv.21832

关键词

rapid test; HIV antibodies; false negative; pediatric; capillus

类别

Virology

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摘要

In a resource-constrained African setting, children suspected of being infected with HIV are often screened with rapid antibody tests prior to definitive diagnosis with viral genome detection. It has previously been shown that a rapid antibody assay such as the Capillus (TM) HIV-1/HIV-2 test may have a high false-negative rate in infants. In this study CD(4)(+) count and percentage, HIV-1 viral load, antigen-specific reactivity, and age was explored as predictors of negative or low antibody reactivity by this assay. Young age was found to be the only factor associated significantly with low antibody reactivity. This phenomenon appeared to be specific to HIV since no such age association was found for antibody reactivity to tetanus toxoid. Rapid assays only validated in adults should therefore be used with utmost caution in young infants since this may lead to high rates of false-negative results. J. Med. Virol. 82:1314-1317, 2010. (C) 2010 Wiley-Liss, Inc.

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A plant-produced SARS-CoV-2 spike protein elicits heterologous immunity in hamsters

Emmanuel Margolin, Georgia Schafer, Joel D. Allen, Sophette Gers, Jeremy Woodward, Andrew D. Sutherland, Melissa Blumenthal, Ann Meyers, Megan L. Shaw, Wolfgang Preiser, Richard Strasser, Max Crispin, Anna-Lise Williamson, Edward P. Rybicki, Ros Chapman

Summary: By applying an integrated host and glyco-engineering approach, a model antigen of the emerging virus SARS-CoV-2 was successfully produced in Nicotiana benthamiana. The protein produced in plants had a similar structure but differed in glycosylation compared to the protein produced in mammalian cells. Animals immunized with the plant-derived antigen showed reduced viral loads, lower lung pathology, and protection from weight loss after challenge, although the protection was not as potent as that induced by the mammalian cell-culture-derived antigen.

FRONTIERS IN PLANT SCIENCE (2023)

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Article Immunology

Barriers that prevent adults living with HBV infection from participating in clinical research: experience from South Africa

Nombuyiselo Mofokeng, Tongai G. Maponga, Marije van Schalkwyk, Susan Hugo, Molefi Daniel Morobadi, Sabeehah Vawda, Leane Badenhorst, Cloete van Vuuren, Christo van Rensburg, Wolfgang Preiser, Jantjie Taljaard, Su Wang, Veronica Miller, Dan Wu, Joseph D. Tucker, Janet Seeley, Dominique Goedhals, Philippa C. Matthews

Summary: High profile international goals have been set for the elimination of hepatitis B virus (HBV) infection as a public health threat by the year 2030. Developing and expanding equitable, accessible translational HBV research programmes that represent real-world populations are an urgent priority for clinical and academic communities. We present experiences and insights by an expert interdisciplinary group focusing on barriers that impede adults living with HBV infection from participating in clinical studies.

JOURNAL OF VIRUS ERADICATION (2023)

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Retraction Multidisciplinary Sciences

撤稿声明: Gradual emergence followed by exponential spread of the SARS-CoV-2 Omicron variant in Africa (Retraction of Vol 378, 10.1126/SCIENCE.ADG2821, 2022)

Carlo Fischer, Tongai Gibson Maponga, Anges Yadouleton, Nuro Abilio, Emmanuel Aboce, Praise Adewumi, Pedro Afonso, Jewelna Akorli, Soa Fy Andriamandimby, Latifa Anga, Yvonne Ashong, Mohamed Amine Beloufa, Aicha Bensalem, Richard Birtel, Anicet Luc Magloire Boumba, Freddi Bwanga, Mike Chaponda, Paradzai Chibukira, R. Matthew Chico, Justin Chileshe, Gershom Chongwe, Assana Cisse, Umberto D'Alessandro, Xavier Nicolas de Lamballerie, Joana F. M. de Morais, Fawzi Derrar, Ndongo Dia, Youssouf Diarra, Lassina Doumbia, Christian Drosten, Philippe Dussart, Richard Echodu, Yannik Eggers, Abdelmajid Eloualid, Ousmane Faye, Torsten Feldt, Anna Fruehauf, Afiwa Halatoko, Pauliana- Vanessa Ilouga, Nalia Ismael, Ronan Jambou, Sheikh Jarju, Antje Kamprad, Ben Katowa, John Kayiwa, Leonard King'wara, Ousmane Koita, Vincent Lacoste, Adamou Lagare, Olfert Landt, Sonia Etenna Lekana-Douki, Jean-Bernard Lekana-Douki, Etuhole Iipumbu, Hugues Loemba, Julius Lutwama, Santou Mamadou, Issaka Maman, Brendon Manyisa, Pedro A. Martinez, Japhet Matoba, Lusia Mhuulu, Andres Moreira-Soto, Judy Mwangi, Nadine N'dilimabaka, Charity Angella Nassuna, Mamadou Ousmane Ndiath, Emmanuel Nepolo, Richard Njouom, Jalal Nourlil, Steven GerNyanjom, Eddy Okoth Odari, Alfred Okeng, Jean Bienvenue Ouoba, Michael Owusu, Irene Owusu Donkor, Karabo Kristen Phadu, Richard Odame Phillips, Wolfgang Preiser, Vurayai Ruhanya, Fortune Salah, Sourakatou Salifou, Amadou Alpha Sall, Augustina Angelina Sylverken, Paul Alain Tagnouokam-Ngoupo, Zekiba Tarnagda, Francis Olivier Tchikaya, Tafese Beyene Tufa, Jan Felix Drexler

SCIENCE (2022)

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Letter Medicine, General & Internal

No point in travel bans if countries with poor surveillance are ignored

Douglas F. Nixon, Robert E. Schwartz, Lishomwa C. Ndhlovu

LANCET (2022)

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