Article
Medicine, General & Internal
Philomena Ehi Airiohuodion, Anh Wartel, Andrew B. Yako, Peter Asaga Mac
Summary: A study in central Nigeria revealed unexpectedly high seroprevalence of HEV and poor feto-maternal outcomes in pregnant women, indicating that the high seropositivity and poor outcomes may be attributed to a combination of intrinsic and extrinsic factors, rather than just HEV viral hepatitis.
FRONTIERS IN MEDICINE
(2022)
Article
Microbiology
Gui-Ping Wen, Min-Ming Wang, Zi-Min Tang, Chang Liu, Zi-Hao Yu, Zheng Wang, Zi-Zheng Zheng, Yu-Lin Zhou, Yun-Sheng Ge
Summary: Hepatitis E virus (HEV) infection may have adverse effects on the health of pregnant women and their infants. A study conducted in China found that although the prevalence of HEV infection among pregnant women was low, a significant proportion of infected women experienced adverse fetal outcomes. These findings are important for the development of appropriate public health interventions.
Review
Cell Biology
Mirco Glitscher, Eberhard Hildt
Summary: The life cycle of hepatitis E virus is poorly understood. The accessory protein pORF3 plays a critical role in viral release and modulating cellular processes beyond just maintaining viral release. Further investigation of pORF3-related processes may lead to novel clinical strategies.
CELLULAR MICROBIOLOGY
(2021)
Article
Infectious Diseases
Luca De Sabato, Elisabetta Suffredini, Simona Di Pasquale, Giuseppina La Rosa, Paola De Santis, Monica Giammarioli, Gabriele Vaccari, Ilaria Di Bartolo
Summary: Wild boar is the main host of genotype 3 of hepatitis E virus (HEV). In a study conducted in central Italy, it was found that there is a significant genetic variability within HEV-3 strains infecting wild boar populations. This highlights the importance of extensive sequencing to understand the diversity, distribution, and evolution of HEV.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Biotechnology & Applied Microbiology
Barbara Kubickova, Joerg A. Schenk, Franziska Ramm, Kornelija Markuskiene, Jochen Reetz, Paul Dremsek, Paulius Lukas Tamosiunas, Laima Cepulyte, Hoai Anh Trinh, Johannes Scholz, Henry Memczak, Marc Hovestaedt, Rene Ryll, Rasa Petraityte-Burneikiene, Victor M. Corman, Anika Andersson, Dietmar Becher, Martin H. Groschup, Stefan Kubick, Frank Sellrie, Reimar Johne, Rainer G. Ulrich
Summary: A hepatitis E virus (HEV) genotype 3-specific monoclonal antibody (mAb) was successfully generated by immunising BALB/c mice with a carboxy-terminal part of its capsid protein expressed in Escherichia coli. The mAb, named G117-AA4, showed strong reactivity with homologous and heterologous HEV-3 capsid proteins, as well as with capsid protein derivatives from other genotypes and related viruses. This novel mAb may prove valuable for further studies on HEV infections and diagnostic purposes.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Elitsa Golkocheva-Markova
Summary: Understanding the molecular mechanism of hepatitis E virus (HEV) is crucial for revealing the pathogenesis of the virus.
Article
Biology
Yakubu Egigogo Raji, Ooi Peck Toung, Niazlin Mohd Taib, Zamberi Bin Sekawi
Summary: HEV is a global public health and economic challenge affecting both humans and animals worldwide. Recent studies suggest endemicity of HEV in both developing and industrialized nations. The virus has diverse transmission routes and potential risk factors.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Microbiology
Zhaobin Zhou, Yinqian Xie, Chunyan Wu, Yuchen Nan
Summary: Hepatitis E virus (HEV) is a zoonotic pathogen responsible for acute hepatitis outbreaks globally. The HEV-ORF2 protein, in addition to forming the viral capsid, plays multiple roles in viral replication and pathogenesis, making it a potential target for vaccine development and treatment of HEV infection.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Hassan M. M. Mahsoub, C. Lynn Heffron, Anna M. M. Hassebroek, Harini Sooryanarain, Bo Wang, Tanya LeRoith, Guillermo Raimundi Rodriguez, Debin Tian, Xiang-Jin Meng
Summary: HEV causes adverse pregnancy outcomes with a mortality rate of >30% in pregnant women. However, the underlying mechanisms are poorly understood. This study utilizes HEV-3ra and pregnant rabbits to investigate the potential mechanisms of pregnancy-associated adverse outcomes during HEV infection.
Article
Virology
Volker Kinast, Mara Kloehn, Maximilian K. Nocke, Daniel Todt, Eike Steinmann
Summary: This review examines the impact of the intimate relationship between viruses and host cells on the host range and adaptation of viruses. It discusses the differences in host range among different genotypes and the role of molecular determinants. Furthermore, it provides insights into techniques and methods to address questions about the host range and adaptation of hepatitis E virus (HEV).
CURRENT OPINION IN VIROLOGY
(2022)
Article
Microbiology
Mengnan Fan, Yuhang Luo, Beibei Zhang, Jiaxi Wang, Tianxiang Chen, Baoyuan Liu, Yani Sun, Yuchen Nan, Julian A. Hiscox, Qin Zhao, En-Min Zhou
Summary: The study confirmed the direct interaction between HEV and CDC42, and identified different CDC42 downstream signaling pathways used by non-enveloped and quasi-enveloped HEV during infection. These results provide new insights into the life cycle of HEV in host cells and offer a new drug design target for combating HEV infection.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Bo Wang, Debin Tian, Harini Sooryanarain, Hassan M. Mahsoub, C. Lynn Heffron, Anna M. Hassebroek, Xiang-Jin Meng
Summary: Hepatitis E virus (HEV) infection in pregnant women often leads to fulminant hepatic failure (FHF) with high mortality rates. Mutations in HEV-1 have been found to be associated with FHF, and two specific mutations have been identified in all FHF cases in Bangladesh. These mutations greatly enhance HEV replication and may explain the rapid viral replication and severe disease in FHF patients. However, these mutations do not affect the replication ability of HEV-3 and do not alter the sensitivity to ribavirin, suggesting that ribavirin can still be used for antiviral therapy in FHF patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Miriam Fritz-Weltin, Lisa Niedermeier, Estelle Frommherz, Nora Isenmann, Benedikt Csernalabics, Tobias Boettler, Christoph Neumann-Haefelin, Dominique Endres, Marcus Panning, Benjamin Berger
Summary: This retrospective study systematically screened 104 patients with Bell's palsy for acute HEV infection, but found no association between acute HEV infection and Bell's palsy. However, a high prevalence of anti-HEV IgG in Bell's palsy patients was observed, which increased with age.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Gastroenterology & Hepatology
Thomas Horvatits, Jan-Erik Wissmann, Reimar Johne, Martin H. Groschup, Ashish K. Gadicherla, Julian Schulze Zur Wiesch, Martin Eiden, Daniel Todt, Rudolph Reimer, Lisa Daehnert, Anja Schoebel, Karoline Horvatits, Rabea Luebke, Christine Wolschke, Francis Ayuk, Meike Rybczynski, Ansgar W. Lohse, Marylyn M. Addo, Eva Herker, Marc Luetgehetmann, Eike Steinmann, Sven Pischke
Summary: The study found HEV-RNA in the seminal plasma and semen of chronically infected patients, with viral loads >2 logs higher than in the serum, indicating the male reproductive system as a niche of HEV persistence in chronic infection. Additionally, HEV particles in the ejaculate did not morphologically differ from serum-derived particles, suggesting a potential route for HEV transmission.
JOURNAL OF HEPATOLOGY
(2021)
Review
Virology
Gergana Zahmanova, Katerina Takova, Valeria Tonova, Tsvetoslav Koynarski, Laura L. Lukov, Ivan Minkov, Maria Pishmisheva, Stanislav Kotsev, Ilia Tsachev, Magdalena Baymakova, Anton P. Andonov
Summary: Hepatitis E virus (HEV) is a major cause of acute viral hepatitis transmitted mainly through ingestion of contaminated water or food, or contact with infected animals and their raw meat products. HEV is a re-emerging virus in developed countries, posing a risk to public health. Preventative efforts and further research on HEV vaccine development are needed to reduce the incidence of HEV infection and its associated complications.
Article
Agriculture, Dairy & Animal Science
L. Montoro-Dasi, A. Villagra, S. Sevilla-Navarro, M. T. Perez-Gracia, S. Vega, C. Marin
Article
Chemistry, Multidisciplinary
Beatriz Suay-Garcia, Jose Ignacio Bueso-Bordils, Antonio Falco, Maria Teresa Perez-Gracia, Gerardo Anton-Fos, Pedro Aleman-Lopez
WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL MOLECULAR SCIENCE
(2020)
Article
Agriculture, Dairy & Animal Science
Laura Montoro-Dasi, Arantxa Villagra, Maria de Toro, Maria Teresa Perez-Gracia, Santiago Vega, Clara Marin
Editorial Material
Microbiology
Beatriz Suay-Garcia, Maria-Teresa Perez-Gracia
Article
Agriculture, Dairy & Animal Science
Laura Montoro-Dasi, Arantxa Villagra, Maria de Toro, Maria Teresa Perez-Gracia, Santiago Vega, Clara Marin
Summary: This research evaluated the differences in caecal microbiota in broilers reared under two different farm conditions during the growing period. The study suggests that microbiota composition can serve as a biomarker of poultry welfare and health, with significant differences found in microbiota diversity at the end of the growing period. Firmicutes was the dominant phylum throughout the growing period, with Proteobacteria and Bacteroidetes also present in varying levels. Overall, optimizing farm management is crucial in promoting animal health and reducing the need for antibiotics.
Article
Agriculture, Dairy & Animal Science
Laura Montoro-Dasi, Arantxa Villagra, Sandra Sevilla-Navarro, Maria Teresa Perez-Gracia, Santiago Vega, Clara Marin
Summary: This study aimed to evaluate the impact of commercial and improved farming conditions on antimicrobial and multidrug resistance dynamics in broilers. The results showed high levels of resistant bacteria throughout the rearing period, with no significant differences between the two groups but both exhibiting high multidrug resistance at slaughter. Further research is needed to better understand the acquisition and prevalence of antimicrobial resistance in poultry under different growing conditions.
Article
Integrative & Complementary Medicine
Sergio Montero Navarro, Sonia del Rio Medina, Jose Martin Botella Rico, Maria Isabel Rocha Ortiz, Maria Teresa Perez Gracia
Summary: Superficial or deep dry needling at MTrP 1 in the upper trapezius led to increased pain pressure threshold and changes in cervical range of motion. However, there were no statistically significant changes observed in PPT or goniometry measurements following a single intervention.
ACUPUNCTURE IN MEDICINE
(2022)
Review
Infectious Diseases
Antonio Tarin-Pello, Beatriz Suay-Garcia, Maria-Teresa Perez-Gracia
Summary: Antibiotic resistance is a major global health threat, with antibiotic-resistant bacteria causing 700,000 deaths annually. This review discusses current and emerging antimicrobial therapies and highlights the potential advantages of drug repurposing and mathematical prediction models in addressing antimicrobial resistance. The development of new antimicrobials remains necessary to combat this global threat.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2022)
Article
Microbiology
Antonio Tarin-Pello, Beatriz Suay-Garcia, Elisa Marco-Crespo, Carolina Galiana-Rosello, Jose I. Bueso-Bordils, Maria-Teresa Perez-Gracia
Summary: Antimicrobial resistance (AMR) is a serious global health issue, and Spain ranks high in antibiotic consumption in Europe. Adequate training on AMR and rational use of antimicrobials is crucial to prevent a post-antibiotic era. The SWICEU project, an academic program about antibiotic discovery, has had a positive impact on pre-university students' knowledge of AMR and rational use of antibiotics. The project has also received high satisfaction from university and pre-university students.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Beatriz Suay-Garcia, Jose-Ignacio Bueso-Bordils, Gerardo Anton-Fos, Maria-Teresa Perez-Gracia, Antonio Falco, Pedro Aleman-Lopez
Summary: Quinolones are widely used antibiotics, but the rise in antibiotic resistance has diminished the effectiveness of many compounds. By utilizing a prediction model, two quinolones were selected and synthesized, along with the discovery of a new type of antibacterial zwitterionic quinolonate.
Review
Gastroenterology & Hepatology
Maria Teresa Perez-Gracia, Antonio Tarin-Pello, Beatriz Suay-Garcia
Summary: In May 2022, the UK reported 176 cases of severe acute hepatitis of unknown etiology in children under 10 years old. Similar cases were subsequently reported in other countries. As of June 17, 2022, a total of 991 cases had been reported globally, with 50 children requiring liver transplant and 28 patient deaths. The cause of these cases remains unknown, but adenovirus has been detected in 62.2% of analyzed samples.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Editorial Material
Microbiology
Anna Kramvis, Maria Teresa Perez-Gracia, Kavita Satish Lole, Manuel Rodriguez-Iglesias, None Shalimar
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Antonio Tarin-Pello, Elisa Marco-Crespo, Beatriz Suay-Garcia, Carolina Galiana-Rosello, Jose Bueso-Bordils, Maria-Teresa Perez-Gracia
Summary: This case study presents the strategies and actions taken by the SWICEU team at CEU Cardenal Herrera University in Spain over the past 5 years to educate and raise awareness about antimicrobial resistance and the correct use of antibiotics. The team has developed innovative gamification supports and utilized various digital communication platforms to successfully engage young people and increase their understanding of the issue.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Laura Montoro-Dasi, Laura Lorenzo-Rebenaque, Adrian Ramon-Moragues, Maria Teresa Perez-Gracia, Maria de Toro, Clara Marin, Arantxa Villagra
Summary: The study aimed to evaluate the effect of antibiotic feed supplementation on microbiota and productive performance in rabbits during the growing period. Results showed that antibiotic supplementation had no effect on microbiota composition and productive performance in the robust genetic line.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Paula Maciel Pires, Andrei Cristian Ionescu, Maria Teresa Perez-Gracia, Elena Vezzoli, Igor Paulino Mendes Soares, Eugenio Brambilla, Aline de Almeida Neves, Salvatore Sauro
Summary: This study evaluated the ability of current ion-releasing materials to remineralize artificial caries lesions. The results showed that calcium silicate-based materials were able to induce apatite deposition and promote hardness recovery of the carious lesions.
CLINICAL ORAL INVESTIGATIONS
(2022)
