期刊
JOURNAL OF MEDICAL VIROLOGY
卷 81, 期 6, 页码 1088-1093出版社
WILEY
DOI: 10.1002/jmv.21485
关键词
EBV antibodies; co-infection; Plasmodium falciparum; Burkitt's lymphoma
类别
资金
- NIH [R01 CA102667, K08 AI 51565]
- Elizabeth Crosby Award
To study the long term the effects of chronic exposure to P. falciparum malaria on Epstein-Barr virus (EBV) reactivation in children, EBV-specific antibody levels were measured in a cross-sectional survey of two groups of Kenyan children with divergent malaria exposure, varying in age from 1 to 14 years. A total of 169 children were analyzed within three age groups (1-4 years, 5-9 years and 10-14 years). Using a Luminex assay, elevated levels of IgG to EBV lytic and latent antigens were observed in children from the holoendemic malaria area; these remained elevated for each age group studied. In comparison, children from the sporadic malaria area had lower levels of EBV-specific IgG antibodies and these levels declined across age groups. These data suggest that chronic exposure to malaria may lead to long-term EBV reactivation. J. Med. Virol. 81:1088-1093, 2009. (c) 2009 Wiley-Liss, Inc.
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