期刊
JOURNAL OF MEDICAL PRIMATOLOGY
卷 43, 期 2, 页码 89-99出版社
WILEY
DOI: 10.1111/jmp.12090
关键词
levonorgestrel; non-human primate; pyrosequencing
资金
- NIH from the Office of Research Infrastructure Programs, National Institutes of Health [P51 OD011133]
BackgroundUse of a levonorgestrel-releasing intrauterine system (LNG-IUS) in humans may alter vaginal microbial populations and susceptibility to pathogens. This study evaluated the time-dependent effects of an LNG-IUS on the vaginal microbiome of the baboon, a useful animal model for reproductive studies. MethodsLevonorgestrel-releasing intrauterine systems were inserted into three reproductively mature, female baboons. The animals were evaluated for 6months by physical examination and Gram-stained cytology. The vaginal microbiota was characterized at each timepoint by culture-independent analysis of the 16S rRNA-encoding gene. ResultsEach baboon harbored a diverse vaginal microbiome. Interindividual variation exceeded intra-individual variation. Diversity declined over time in one baboon and showed mild fluctuations in the other two. There were no significant community differences from early to late post-LNG-IUS placement. ConclusionsThe baboon vaginal microbiome is unique to each individual and is polymicrobial. In this pilot study, the vaginal microbiome remained stable from early to late post-LNG-IUS placement.
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