Review
Immunology
Peng Liu, Yune Lu, Rongguo Li, Xiaodi Chen
Summary: The vaginal microbiome is colonized by a variety of microorganisms, with lactobacilli being the most common. Lactobacilli can acidify the vagina and prevent the growth of pathogenic microorganisms, thus maintaining a healthy vaginal microbiome. Decreased levels of lactobacilli have been associated with various vaginal infections and serious health consequences. Probiotic lactobacilli, recognized as safe, have been utilized as an alternative or adjunct to antibiotics for treating vaginal infections and restoring the vaginal microbiome. This review focuses on the important role of probiotic lactobacilli in the vaginal microenvironment and their use in vitro and in vivo for treating female vaginal infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Rachel L. Shapiro, Kevin DeLong, Fareeha Zulfiqar, Davell Carter, Marina Better, Laura M. Ensign
Summary: Vaginal drug delivery systems are preferred for treating female reproductive tract diseases with fewer systemic side effects, but face anatomical and biological barriers. In vitro and ex vivo models are crucial for evaluating these systems. Advanced model systems for other mucosa can inspire future development for the female reproductive tract.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Immunology
James A. Johnson, Lydia F. Delaney, Vaishali Ojha, Medha Rudraraju, Kaylie R. Hintze, Nazema Y. Siddiqui, Tatyana A. Sysoeva
Summary: This study assessed the functional abilities of urinary lactobacilli in postmenopausal women and found that they strongly inhibit gram-negative Escherichia coli and Klebsiella pneumoniae, but have less inhibition against gram-positive Enterococcus faecalis. These findings suggest a potential interaction between urinary lactobacilli and the urinary microbiome.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Marina Scillato, Ambra Spitale, Gino Mongelli, Grete Francesca Privitera, Katia Mangano, Antonio Cianci, Stefania Stefani, Maria Santagati
Summary: The study found that Lactobacilli in healthy vaginal microbiota exhibit strong intervention and co-aggregation abilities against urogenital pathogens, making them potential candidates for a new vaginal probiotic formulation against infections. However, further in vivo studies are needed to assess their actual health benefits for humans in clinical situations.
Article
Obstetrics & Gynecology
Cecilia Hernandez-Bonilla, Diego Zacapa, Rene Zempoalteca, Dora Luz Corona-Quintanilla, Francisco Castelan, Margarita Martinez-Gomez
Summary: Unlike male mammals, female mammals have urogenital sphincters shaped by muscles like the urethrovaginal sphincter. Childbirth-related injuries can affect the function of urogenital sphincters in women, leading to pelvic floor disorders. This study investigated the effect of multiparity on the pressure generated by the bulboglandularis muscle (Bgm) in rabbits and found that multiparity reduced the weight and width of Bgm and impaired urethral and vaginal pressures.
REPRODUCTIVE SCIENCES
(2023)
Article
Infectious Diseases
Slawomir Letkiewicz, Marzanna Lusiak-Szelachowska, Ryszard Miedzybrodzki, Maciej Zaczek, Beata Weber-Dabrowska, Andrzej Gorski
Summary: Phage therapy for urogenital infections showed promising results, with low antibody responses in patients.
Article
Obstetrics & Gynecology
Sidi Dun, Chunying Liu, Na Li
Summary: The correlation between intrauterine adhesions (IUA) and vaginal microecology was investigated in this study. It was found that patients with IUA had a higher incidence of abnormal vaginal microecology, characterized by higher vaginal pH, reduction of Lactobacillus, increased ratio of flora density I, IV, increased flora diversity I, IV, and higher detection rate of trichomonas vaginitis (TV) and bacterial vaginosis (BV).
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2023)
Article
Microbiology
David Jose Delgado-Diaz, Brianna Jesaveluk, Joshua A. Hayward, David Tyssen, Arghavan Alisoltani, Matthys Potgieter, Liam Bell, Elizabeth Ross, Arash Iranzadeh, Imane Allali, Smritee Dabee, Shaun Barnabas, Hoyam Gamieldien, Jonathan M. Blackburn, Nicola Mulder, Steven B. Smith, Vonetta L. Edwards, Adam D. Burgener, Linda-Gail Bekker, Jacques Ravel, Jo-Ann S. Passmore, Lindi Masson, Anna C. Hearps, Gilda Tachedjian
Summary: Women with a cervicovaginal microbiota dominated by Lactobacillus spp. produce lactic acid, which enhances genital epithelial barrier integrity and helps prevent invasion by sexually transmitted pathogens.
Review
Biochemistry & Molecular Biology
Amanda Kornel, Matteo Nadile, Maria Ilektra Retsidou, Minas Sakellakis, Katerina Gioti, Apostolos Beloukas, Newman Siu Kwan Sze, Panagiota Klentrou, Evangelia Tsiani
Summary: Prostate cancer is a major global health issue, with a high number of cases and deaths. Plant-derived compounds, such as ursolic acid found in cranberries, have shown promise in inhibiting the growth of prostate and other urogenital cancers. Further research and clinical studies are needed to fully understand the potential of ursolic acid in cancer prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Kairi Koort, Kristiina Sosa, Silver Turk, Eleri Lapp, Elle Talving, Peeter Karits, Karin Rosenstein, Madis Jaagura, Aire Sekavin, Deniss Soritsa, Kai Haldre, Helle Karro, Paul Korrovits, Andres Salumets, Reet Mandar
Summary: Despite advances in assisted reproductive technologies, the implantation rate of transferred embryos remains low and the reasons for failure are unclear. This study aimed to investigate the impact of the reproductive tract microbiome on ART outcome. The results suggest that microbiome disturbances in both partners are associated with infertility and lower ART success rates, highlighting the importance of addressing this issue in ART procedures.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Microbiology
Ji-Eun Yeu, Hyeon-Gyu Lee, Geun-Yeong Park, Jisun Lee, Mi-Sun Kang
Summary: The study found that Weissella cibaria probiotics have excellent antimicrobial and antibiofilm properties, effectively killing various upper respiratory tract infection pathogens and inhibiting biofilm formation. This offers new possibilities for the prevention and treatment of bacterial upper respiratory tract infections.
Review
Gastroenterology & Hepatology
Nayere Taebnia, Ute Romling, Volker M. Lauschke
Summary: Enteric bacterial infections are a major cause of disease and mortality worldwide, especially in developing countries. In vitro 2D monolayer cultures have provided valuable insights into the virulence mechanisms of various pathogens, leading to the discovery of potential targets for antimicrobial therapy and vaccines. More complex models, such as organoids, 3D bioengineered scaffolds, and microphysiological devices, have expanded our understanding of the effects of physiological and biological factors on infection. Advances in ex vivo cultures and intravital imaging have also allowed for the study of enteric pathogens on fluid secretion, barrier integrity, and immune cell surveillance. The combined use of these different methods promises to enhance our understanding of host-microbe interactions and their impact on intestinal health.
Article
Food Science & Technology
Wanting Wang, Yiqiong Yuan, Jun Cao, Xuanri Shen, Chuan Li
Summary: The study found that HLP exhibited good fermentability both in vitro and in vivo, and significantly enhanced liver antioxidant activity in mice.
Review
Medicine, General & Internal
Tomislav Mestrovic, Mario Matijasic, Mihaela Peric, Hana Cipcic Paljetak, Anja Baresic, Donatella Verbanac
Summary: The current research focuses on the relationship between gut microbiota and the development of bacteriuria and UTI, as well as the potential impact of vaginal dysbiosis and urinary microbiome perturbations on infections. Further research and exploration are needed to understand and potentially utilize these findings for the diagnosis and treatment of UTIs.
Article
Biotechnology & Applied Microbiology
Shreaya Das, Bolin Kumar Konwar
Summary: In the vaginal canal, beneficial and pathogenic microbes coexist, and a decrease in lactic acid bacteria may result in recurring urogenital infections. Four probiotic bacteria, including Lactobacillus crispatus, exhibited antimicrobial effects against various urogenital pathogens, with L. crispatus being the most effective. Encapsulation of L. crispatus cells in a carboxy-methyl cellulose-alginate matrix retained the probiotic's viability and showed potential as an additive to enhance vaginal health.
INTERNATIONAL MICROBIOLOGY
(2023)
Article
Immunology
Priscilla Romina De Gregorio, Maria Silvina Juarez Tomas, Maria Elena Fatima Nader-Macias
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2016)
Article
Pharmacology & Pharmacy
Maria Silvina Juarez Tomas, Priscilla Romina De Gregorio, Maria Cecilia Leccese Terraf, Maria Elena Fatima Nader-Macias
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2015)
Article
Biotechnology & Applied Microbiology
P. R. De Gregorio, M. S. Juarez Tomas, M. C. Leccese Terraf, M. E. F. Nader-Macias
JOURNAL OF APPLIED MICROBIOLOGY
(2015)
Article
Plant Sciences
G. Michavila, C. Adler, P. R. De Gregorio, M. J. Lami, M. C. Caram Di Santo, A. M. Zenoff, R. E. de Cristobal, P. A. Vincent
Article
Multidisciplinary Sciences
Priscilla Romina De Gregorio, Gabriela Michavila, Lenise Ricciardi Muller, Clarissa de Souza Borges, Maria Fernanda Pomares, Enilson Luiz Sacco de Sa, Claudio Pereira, Paula Andrea Vincent
Article
Microbiology
Priscilla Romina De Gregorio, Maria Silvina Juarez Tomas, Viviana Santos, Maria Elena Fatima Nader-Macias
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
(2012)
Article
Obstetrics & Gynecology
Maria S. Juarez Tomas, Carolina I. Saralegui Duhart, Priscilla R. De Gregorio, Esteban Vera Pingitore, Maria E. Nader-Macias
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2011)
Article
Microbiology
P. R. De Gregorio, N. C. Maldonado, E. Vera Pingitore, M. C. Leccese Terraf, M. S. Juarez Tomas, C. Silva de Ruiz, V Santos, B. Wiese, E. Bru, M. C. Paiz, M. F. Reina, D. E. Schujman, M. E. F. Nader-Macias
BENEFICIAL MICROBES
(2020)
Article
Biotechnology & Applied Microbiology
Priscilla Romina De Gregorio, Carola Parolin, Angela Abruzzo, Barbara Luppi, Michele Protti, Laura Mercolini, Jessica Alejandra Silva, Barbara Giordani, Antonella Marangoni, Maria Elena Fatima Nader-Macias, Beatrice Vitali
MICROBIAL CELL FACTORIES
(2020)
Article
Pharmacology & Pharmacy
Jessica Alejandra Silva, Priscilla Romina De Gregorio, Guadalupe Rivero, Gustavo A. Abraham, Maria Elena Fatima Nader-Macias
Summary: This study evaluated the survival of Lactobacillus gasseri and Lactobacillus rhamnosus immobilized in nanofibers, finding that L. rhamnosus had a higher survival rate than L. gasseri. Oxygen-excluding packaging was shown to be an effective strategy to extend the shelf-life of L. rhamnosus in nanofibers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Infectious Diseases
Angela Abruzzo, Barbara Giordani, Carola Parolin, Priscilla R. De Gregorio, Claudio Foschi, Teresa Cerchiara, Federica Bigucci, Beatrice Vitali, Barbara Luppi
Summary: This study utilized biosurfactants produced by Lactobacillus to counteract Candida infections, demonstrating significant anti-biofilm activity and good stability and mucoadhesive properties through the preparation of liposomes or liposomes coated with hyaluronic acid.
Review
Pharmacology & Pharmacy
Maria Elena Fatima Nader-Macias, Priscilla Romina De Gregorio, Jessica Alejandra Silva
Summary: This article discusses the importance of lactobacilli in the healthy human vagina and the potential use of probiotics for preventing and treating female urogenital tract infections. It emphasizes the list of requirements for developing probiotic products/formulas for the female UGT.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2021)
Article
Biotechnology & Applied Microbiology
Priscilla Romina De Gregorio, Jessica Alejandra Silva, Antonella Marchesi, Maria Elena Fatima Nader-Macias
FEMS YEAST RESEARCH
(2019)
Article
Veterinary Sciences
Priscilla Romina De Gregorio, Susana Salva, Maria Silvina Juarez Tomas, Maria Elena Fatima Nader-Macias
SCANDINAVIAN JOURNAL OF LABORATORY ANIMAL SCIENCE
(2018)