期刊
JOURNAL OF MEDICAL MICROBIOLOGY
卷 57, 期 6, 页码 690-696出版社
MICROBIOLOGY SOC
DOI: 10.1099/jmm.0.47742-0
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The pathogenicity of Clostridium difficile depends on the large clostridial glucosylating toxins A and B (TcdA and TcdB). The proteins accomplish their own uptake by a modular structure comprising a catalytic and a binding/translocation domain. Based on a proteolytic processing step solely the catalytic domain reaches the cytosol. Within the cells, the glucosyltransferases inactivate small GTIPases by mono-O-glucosylation. Here, a short overview is given regarding latest insights into the intramolecular processing, which is mediated by an intrinsic protease activity.
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