期刊
PEDIATRIC INFECTIOUS DISEASE JOURNAL
卷 34, 期 5, 页码 544-545出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0000000000000667
关键词
Staphylococcus aureus; vitamin D; 25-hydroxyvitamin D; LL-37; cathelicidin
资金
- Children's Discovery Institute of Washington University
- St. Louis Children's Hospital
- National Institutes of Health (NIH) [K23-AI091690, UL1-TR000448]
- Agency for Healthcare Research and Quality (AHRQ) [R01-HS021736]
Vitamin D promotes epithelial immunity by upregulating antimicrobial peptides, including LL-37, which have bactericidal activity against Staphylococcus aureus. We found that children with vitamin D deficiency or insufficiency [25-hydroxyvitamin D <30 ng/mL] were more likely to present with recurrent, rather than primary, S. aureus skin or soft tissue infection. Vitamin D sufficiency may be one of a myriad of host and environmental factors that can be directly impacted to reduce the frequency of S. aureus skin and soft tissue infection.
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