Article
Clinical Neurology
Laura P. Westphal, Niklas Lohaus, Sebastian Winklhofer, Christian Manzolini, Ulrike Held, Klaus Steigmiller, Janne M. Hamann, Mohamad El Amki, Tomas Dobrocky, Leonidas D. Panos, Johannes Kaesmacher, Urs Fischer, Mirjam R. Heldner, Andreas R. Luft, Jan Gralla, Marcel Arnold, Roland Wiest, Susanne Wegener
Summary: The study found no evidence of an association between Circle of Willis variants and clinical outcomes in LVO stroke patients undergoing EVT. However, there were trends towards higher mortality in patients with any type of CoW variant, particularly among those with incomplete CoW who died within 3 months after stroke onset.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eaton Lin, Hooman Kamel, Ajay Gupta, Arindam RoyChoudhury, Peter Girgis, Lidia Glodzik
Summary: This study suggests that the variants of the circle of Willis may be associated with a poorer prognosis for stroke patients.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Clinical Neurology
Jolanda De Caro, Antonio Ciacciarelli, Agostino Tessitore, Orazio Buonomo, Andrea Calzoni, Isabella Francalanza, Cristina Dell'Aera, Domenico Cosenza, Carmelo Tiberio Curro, Francesca Granata, Sergio Lucio Vinci, Giuseppe Trimarchi, Antonio Toscano, Rosa Fortunata Musolino, Paolino La Spina
Summary: The study aimed to provide prevalence and pattern of anatomical variants of the circle of Willis in ischemic stroke patients and controls, and to determine their role in severity and prognosis. Results showed higher prevalence of variants in stroke patients, who were older but had similar outcomes compared to those with typical circle of Willis.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Ida Rangus, Lennart S. Milles, Ivana Galinovic, Kersten Villringer, Heinrich J. Audebert, Jochen B. Fiebach, Christian H. Nolte, Hebun Erdur
Summary: Variants of the Circle of Willis (vCoW) are present in about one-third of stroke patients, more commonly in the posterior circulation. Reclassifications of stroke lesion patterns due to vCoW primarily occur in the posterior circulation, with fetal posterior cerebral artery mimicking multiple territory stroke pattern. Considering vCoW in these cases may uncover symptomatic carotid disease.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Multidisciplinary Sciences
Adam Piechna, Krzysztof Cieslicki
Summary: This paper presents a zero-dimensional cerebral circulation model with hydrodynamic nonlinearities and autoregulation mechanisms, which is verified using a computational fluid dynamics model. Despite its simplicity, the model captures the dominant features of cerebral circulation and demonstrates good agreement with the CFD model. The practical application of the model in predicting autoregulation pressure reserve for different diameters of natural anastomoses is discussed, along with the advantages and limitations of the model.
SCIENTIFIC REPORTS
(2023)
Article
Peripheral Vascular Disease
Nathan E. Manghat, Elizabeth Robinson, Konstantina Mitrousi, Jonathan C. L. Rodrigues, Thomas Hinton, Julian F. R. Paton, Richard G. Wise, Angus K. Nightingale, Emma C. Hart
Summary: Variants in the posterior anatomy of the cerebral circulation are associated with hypertension and poor cerebral perfusion in young adults, indicating potential long-term consequences on cerebrovascular health.
Article
Neurosciences
Laszlo Orosz, Zoltan Gyongyosi, Zsolt Susan, Peter Siro, Arjan Willem Hoksbergen, Laszlo Csiba, Bela Fulesdi
Summary: This study assessed the variations and vessel diameters of the circle of Willis in a Central European cohort. The results showed that complete circle of Willis was present in more than 60% of patients without a history of stroke.
TRANSLATIONAL NEUROSCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Maciej Zdun, Jakub J. Ruszkowski, Maciej Gogulski, Agata Jozefiak, Mateusz Hetman
Summary: This study described the anatomy of arterial vessels that supply blood to the brain in the red-necked wallaby and compared it with other mammalian groups. The findings can contribute to further physiological and pathophysiological studies.
Article
Clinical Neurology
Yang Liu, Lei Zhu, Bei Hou, Tuoyi Wang, Dechao Xu, Chenxi Tan, Huiyi Zhang, Chunyan Li, Jianan Wang
Summary: This study analyzed 30 patients with bilateral CAO, showing that the collateral circulation pathway varies among patients with different CoW structure types. When the CoW is partially complete, it mainly provides blood flow compensation to the ischemic area through primary collateral circulation. When the CoW is incomplete, it mainly provides blood flow compensation to the ischemic area through secondary collateral circulation.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Jia Li, Lu Zheng, Wen-Jie Yang, Cheuk-Yin Sze-To, Thomas Wai-Hong Leung, Xiang-Yan Chen
Summary: The completeness of the Circle of Willis (COW) could influence the vessel wall distribution of middle cerebral artery (MCA) plaques, with symptomatic MCA plaques causing perforator infarctions more likely to be located on the superior wall.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Felix Dumais, Marco Perez Caceres, Felix Janelle, Kassem Seifeldine, Noemie Ares-Bruneau, Jose Gutierrez, Christian Bocti, Kevin Whittingstall
Summary: A deep convolutional neural network method was developed to accurately segment and quantify Circle of Willis (CW) arteries on Magnetic Resonance Angiography images. This method showed reliable results in both qualitative and quantitative assessments, and demonstrated high reliability in test-retest analysis.
Article
Biochemistry & Molecular Biology
Sara Sablic, Kresimir Dolic, Ivan Kraljevic, Danijela Budimir Mrsic, Mate Cicmir-Vestic, Benjamin Benzon, Sanja Lovric Kojundzic, MajaMarinovic Guic
Summary: This study examined the correlation between anatomical variants of Willis' circle and AIS in patients treated with mechanical thrombectomy. The results showed that patients with communicating arteries had better treatment outcomes and functional recovery. ACoA had a greater impact on the outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Shiori Amemiya, Naoyuki Takei, Tsuyoshi Ueyama, Keita Fujii, Hidemasa Takao, Koichiro Yasaka, Yusuke Watanabe, Kouhei Kamiya, Osamu Abe
Summary: This study developed an accelerated cervical MRA and evaluated its diagnostic performance. The results showed that FLEXA had significantly higher artery-to-background signal ratio, lower image blurring, and better diagnostic performance for luminal abnormalities and plaques compared to cMRA.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Timothy J. Hunter, Jermiah J. Joseph, Udunna Anazodo, Sanjay R. Kharche, Christopher W. McIntyre, Daniel Goldman
Summary: A novel cardio-cerebral lumped parameter hemodynamic model was developed to investigate the impact of Circle of Willis (CoW) variants on cerebral blood flow dynamics under atrial fibrillation conditions. The study found that the geometry of the CoW influenced the frequency of hypoperfusion events, with the variant missing a P1 segment having the highest risk at lower heart rates.
APPLIED SCIENCES-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Yuanyuan Shen, Yanji Wei, Reinoud P. H. Bokkers, Maarten Uyttenboogaart, J. Marc C. Van Dijk
Summary: In this study, a numerical framework for modeling patient-specific cerebral blood flow was proposed. The framework utilized commonly available clinical datasets to extract arterial geometry parameters and employed flow information obtained from transcranial Doppler measurement for calibration. The results demonstrated that the proposed model could accurately reproduce blood flow in the circle of Willis for each patient, with the resistance at the distal end of each terminal branch being the primary parameter for flow distribution. This model holds promise as a useful tool for assessing cerebral hemodynamics in patients with cerebrovascular diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)