Article
Infectious Diseases
Kelsilandia Aguiar Martins, Maria Helena de Athayde Meirelles, Tiago Feitosa Mota, Ibrahim Abbasi, Artur Trancoso Lopo de Queiroz, Claudia Ida Brodskyn, Patricia Sampaio Tavares Veras, Deborah Bittencourt Mothe Fraga, Alon Warburg
Summary: The study found that female sand flies select oviposition sites based on the potential for larval maturation, and that composting cashew leaf litter hindered development while larvae reared on chicken feces developed rapidly. Adult females from larvae reared on chicken coop substrates were highly susceptible to Leishmania infection.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Parasitology
Herintha Coeto Neitzke-Abreu, Gabriel Barbosa Costa, Milena Nunes da Silva, Edith Palacio, Alexandre da Silva Cardoso, Paulo Silva de Almeida, Manoel Sebastiao da Costa Lima-Junior
Summary: Sand flies and cases of visceral and cutaneous leishmaniases have been reported in almost all municipalities in the State of Mato Grosso do Sul, Brazil. The study reveals an expansion in the geographical distribution of VL and CL during the study period, and the presence of sand fly vectors in non-endemic municipalities.
PARASITES & VECTORS
(2022)
Review
Microbiology
Sahaana Arumugam, Breanna M. Scorza, Christine Petersen
Summary: In this article, we reviewed dermatoimmunology during visceral leishmaniasis (VL), dermal Leishmania parasite burden, and the role of skin parasitism in transmissibility to sand fly vectors. We discussed the epidemiology of VL among dogs and explored the association between spatial distribution and the burden of parasites in the skin. Factors associated with parasite persistence in the skin were examined. We also discussed systemic immunity during VL and what is known about immunological correlates in the skin microenvironment. Finally, we touched on factors egested into the skin during Leishmania inoculation by sand flies and the role of the dermal immune response.
Review
Biology
Pedro Cecilio, Anabela Cordeiro-da-Silva, Fabiano Oliveira
Summary: This review discusses various aspects of sand flies as vectors of Leishmania parasites, including their basic biology, ecology, and interactions with the parasites. It highlights the need to study the vectors as well as the diseases and etiological agents.
COMMUNICATIONS BIOLOGY
(2022)
Article
Parasitology
Barrack O. Owino, Jackline Milkah Mwangi, Steve Kiplagat, Hannah Njiriku Mwangi, Johnstone M. Ingonga, Alphine Chebet, Philip M. Ngumbi, Jandouwe Villinger, Daniel K. Masiga, Damaris Matoke-Muhia
Summary: The study investigated transmission, vector abundance, distribution, and reservoir hosts of Leishmania in Merti sub-County, Kenya. Findings suggest potential involvement of Sergentomyia sand flies in Leishmania transmission, questioning the exclusively Phlebotomus sand flies' role in human leishmaniases. The presence of Trypanosoma DNA indicates possible mechanical transmission and the preference for different blood meal hosts was observed.
PARASITES & VECTORS
(2021)
Article
Microbiology
Monica E. Staniek, James G. C. Hamilton
Summary: Visceral leishmaniasis caused by the Protist parasite Leishmania infantum leads to thousands of human deaths annually in Brazil and other South and Central American countries. Research has shown that the odour of dogs infected with Le. infantum is significantly more attractive to female sand flies, potentially enhancing infection and transmission opportunities for the parasite. This suggests infected dogs may play a disproportionate role in maintaining infection in both canine and human populations.
Article
Parasitology
Lucie Ticha, Jovana Sadlova, Paul Bates, Petr Volf
Summary: The development of Sauroleishmania parasites in sand flies varies depending on the sand fly species infected. P. orientalis and P. argentipes were found to be highly susceptible to Sauroleishmania, with the parasites developing mature infections including colonization of the sand fly stomodeal valve.
PARASITES & VECTORS
(2022)
Article
Public, Environmental & Occupational Health
Debashis Ghosh, Abdul Alim, M. Mamun Huda, Christine M. Halleux, Md Almahmud, Piero L. Olliaro, Greg Matlashewski, Axel Kroeger, Dinesh Mondal
Summary: This pilot study compared the effects of different vector control tools on sandfly densities and mortality, and found varying effectiveness and acceptability of existing interventions at different time points. The results will guide the National Kala-azar Elimination Program in selecting appropriate control tools during the elimination process.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Parasitology
Debora Cristina Capucci, Aldenise Martins Campos, Joao Vitor Reis Soares, Vladimir Diniz Vieira Ramos, Camila Binder, Mariana Alves Lima, Carina Margonari, Jose Dilermando Andrade Filho
Summary: This study captured sand flies in different ecotopes in the municipality of Pains to understand their dynamics. A total of 1,352 sand flies were captured, representing 24 species belong to ten genera. Leishmania DNA was detected in a small number of sand flies, but it confirmed the importance of sand fly populations in different ecotopes.
Article
Infectious Diseases
Laura Posada-Lopez, Andres Velez-Mira, Omar Cantillo, Adriana Castillo-Castaneda, Juan David Ramirez, Eunice A. B. Galati, Fredy Galvis-Ovallos
Summary: This study aimed to determine the ecological interactions between sand flies, Leishmania parasites, and their blood sources. The results showed that the interactions between sand fly species, local mammalian fauna, and the Leishmania parasite are important factors in maintaining the disease in the endemic area.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Multidisciplinary Sciences
Israel de Souza Pinto, Bruno Leite Rodrigues, Thais de Araujo-Pereira, Paloma Helena Fernandes Shimabukuro, Daniela de Pita-Pereira, Constanca Britto, Reginaldo Pecanha Brazil
Summary: Using DNA barcoding, we identified different species of sand flies in forest fragments in Brasileia, state of Acre, Brazil. We generated new COI sequences for 11 species, which had not been sequenced before, and found hidden diversity of five species. The DNA barcoding approach proved to be useful for molecular identification of sand flies and detecting cryptic diversity.
Review
Parasitology
Douglas de Almeida Rocha, Lidiane Medeiros da Costa, Grasielle DAvila Caldas Pessoa, Marcos Takashi Obara
Summary: The review analyzes the susceptibility of sand flies to insecticides, highlighting the lack of specific protocols for assessing their susceptibility. It suggests using CDC bottle tests with SRL for a quick detection of sand flies' resistance to insecticides.
Article
Public, Environmental & Occupational Health
Megha Raj Banjara, Anand Ballabh Joshi, Vivek Kumar Singh, Murari Lal Das, Chitra Kumar Gurung, Piero Olliaro, Christine Halleux, Greg Matlashewski, Axel Kroeger
Summary: The visceral leishmaniasis elimination program in Nepal is progressing towards consolidation and maintenance phases. However, new VL foci are appearing, requiring the development and testing of innovative community-centered strategies. Early case detection combined with sandfly control through indoor residual spraying (IRS) or insecticidal wall painting (IWP) has shown efficacy and cost-effectiveness in new and low-endemic districts of Palpa and Surkhet.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Biochemistry & Molecular Biology
Aakriti Singh, Ganesh Yadagiri, Manorma Negi, Anurag Kumar Kushwaha, Om Prakash Singh, Shyam Sundar, Shyam Lal Mudavath
Summary: In this study, carboxymethyl chitosan (CMC) grafted lipid nanoformulations were prepared as an efficient carrier for amphotericin B (AmB) to treat leishmaniasis. The nanoformulations showed good physicochemical characteristics, controlled drug release, and high antileishmanial activity without causing toxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Immunology
Rajesh Garlapati, Eva Iniguez, Tiago D. Serafim, Prabhas K. Mishra, Basab Rooj, Bikas Sinha, Jesus G. Valenzuela, Sridhar Srikantiah, Caryn Bern, Shaden Kamhawi
Summary: Visceral leishmaniasis (VL) is a potentially deadly parasitic disease prevalent in the northern part of the Indian sub-continent. India, Bangladesh, and Nepal are working together to eliminate VL as a public health problem by 2020 through early detection, prompt treatment, and vector control measures. Despite being close to the elimination target, important aspects of vector biology and sand fly transmission dynamics still need to be determined to ensure sustained elimination.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Saliou Niassy, Amanuel Tamiru, James G. C. Hamilton, William D. J. Kirk, Roland Mumm, Cassie Sims, Willem Jan de Kogel, Sunday Ekesi, Nguya K. Maniania, Krishnakumari Bandi, Fraser Mitchell, Sevgan Subramanian
JOURNAL OF CHEMICAL ECOLOGY
(2019)
Article
Parasitology
Mikel A. Gonzalez, Melissa J. Bell, Scott A. Bernhardt, Reginaldo P. Brazil, Erin Dilger, Orin Courtenay, James G. C. Hamilton
PARASITES & VECTORS
(2019)
Article
Chemistry, Organic
Matthew J. Palframan, Krishna K. Bandi, James G. C. Hamilton, Gerald Pattenden
Article
Infectious Diseases
Monica E. Staniek, Luigi Sedda, Tim D. Gibson, Cristian F. de Souza, Erika M. Costa, Rod J. Dillon, James G. C. Hamilton
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Multidisciplinary Sciences
Alejandra S. Araki, Reginaldo P. Brazil, James G. C. Hamilton, Felipe M. Vigoder
SCIENTIFIC REPORTS
(2020)
Article
Infectious Diseases
Mikel A. Gonzalez, Melissa Bell, Cristian F. Souza, Rafael Maciel-de-Freitas, Reginaldo P. Brazil, Orin Courtenay, James G. C. Hamilton
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Infectious Diseases
Raquel Goncalves, Cristian F. de Souza, Reila B. Rontani, Alisson Pereira, Katie B. Farnes, Erin E. Gorsich, Rafaella A. Silva, Reginaldo P. Brazil, James G. C. Hamilton, Orin Courtenay
Summary: A novel method using synthetic sex-aggregation pheromone combined with insecticide was found to effectively reduce sand fly abundance in a Brazilian community study.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Microbiology
Monica E. Staniek, James G. C. Hamilton
Summary: Visceral leishmaniasis caused by the Protist parasite Leishmania infantum leads to thousands of human deaths annually in Brazil and other South and Central American countries. Research has shown that the odour of dogs infected with Le. infantum is significantly more attractive to female sand flies, potentially enhancing infection and transmission opportunities for the parasite. This suggests infected dogs may play a disproportionate role in maintaining infection in both canine and human populations.
Article
Microbiology
Renata Retkute, Erin Dilger, James G. C. Hamilton, Matt J. Keeling, Orin Courtenay
Summary: The synthetic pheromone can attract approximately 53% of host-seeking female Lu. longipalpis, out-competing other host odors. This suggests that the synthetic pheromone can lure vectors away from humans and dogs, thereby providing protection against transmission of zoontic visceral leishmaniasis.
Article
Infectious Diseases
Ifhem Chelbi, Khouloud Maghraoui, Sami Zhioua, Saifedine Cherni, Imen Labidi, Abhay Satoskar, James G. C. Hamilton, Elyes Zhioua
Summary: Zoonotic visceral leishmaniasis is a tropical disease caused by parasites, mainly affecting children under 5 years old. Infected dogs have been found to be more attractive to vectors, potentially increasing the chances of successful transmission of the disease.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Infectious Diseases
Gabriel B. Tonelli, Jose D. Andrade-Filho, Aldenise M. Campos, Carina Margonari, Amanda R. Amaral, Petr Volf, Elisabeth J. Shaw, James G. C. Hamilton
Summary: SEM examination revealed substantial differences in the interior cuticular secretory apparatus of different species of New World sand flies, which may be related to the chemical structure of pheromones and potentially have taxonomic value. The discovery of a new structure associated with pheromone release, named the manifold, provides insights into pheromone production in these insects.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Entomology
Lesley Bell-Sakyi, Alexandra Beliavskaia, Catherine S. Hartley, Laura Jones, Lisa Luu, Lee R. Haines, James G. C. Hamilton, Alistair C. Darby, Benjamin L. Makepeace
Summary: Wolbachia bacteria, carried by various arthropods and nematodes, interact with hosts in diverse ways and play a crucial role in controlling diseases such as dengue and malaria. Newly isolated strains and cell lines from mosquito and sand fly vectors provide valuable resources for research on host-endosymbiont relationships and disease transmission.
Article
Parasitology
Vanessa de Araujo Barbosa, Cristian F. de Souza, Alisson Pereira, Derek Gatherer, Reginaldo P. Brazil, Daniel P. Bray, James G. C. Hamilton
Summary: The study found that insecticide-impregnated netting and insecticide residual spraying were both effective in killing sand flies in chicken sheds, with insecticide spray showing a slightly better long-term effect. However, the effectiveness of the netting decreased over time when exposed to environmental conditions.
CURRENT RESEARCH IN PARASITOLOGY & VECTOR-BORNE DISEASES
(2021)
Article
Parasitology
Mikel A. Gonzalez, Erin Dilger, Maria M. Ronderos, Gustavo R. Spinelli, Orin Courtenay, James G. C. Hamilton
PARASITES & VECTORS
(2020)