Article
Medicine, Research & Experimental
Kuei-Yen Tsai, Yu-Jia Chang, Chien-Yu Huang, G. M. Shazzad Hossain Prince, Hsin-An Chen, Precious Takondwa Makondi, Ying-Rou Shen, Po-Li Wei
Summary: This study found that heavily fucosylated glycans (HFGs) are overexpressed in colorectal cancer tissues compared to normal tissues. Treatment with anti-HFG monoclonal antibody showed cytotoxic effects in colorectal cancer cells and inhibited tumor growth in a xenograft mouse model. HFGs could be a potential therapeutic target for colorectal cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Hasan Cagri Yildirim, Gozde Kavgaci, Elvin Chalabiyev, Omer Dizdar
Summary: Hepatocellular cancer and biliary tract cancers have poor prognosis, but early diagnosis can lead to curative treatment. This review discusses the recommended diagnostic tests for early detection and recent advancements in this field.
Review
Health Care Sciences & Services
Anthony E. Rizzo, Jennifer C. Gordon, Alicia R. Berard, Adam D. Burgener, Stefanie Avril
Summary: Recent studies have shown the existence of a microbiome in the upper female reproductive tract, previously assumed to be sterile under non-pathologic conditions. While the vaginal microbiome and its impact on reproductive health have been extensively studied, research on the microbiome of the upper female reproductive tract in gynecologic cancers is limited.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Medicine, Research & Experimental
Yihui Yang, Liwen Ren, Wan Li, Yizhi Zhang, Sen Zhang, Binbin Ge, Hong Yang, Guanhua Du, Bo Tang, Hongquan Wang, Jinhua Wang
Summary: GABA is a common inhibitory neurotransmitter in the central nervous system of vertebrates, and recent studies have shown its involvement in tumor development and immune regulation. This review summarizes the role of GABAergic signaling in tumor proliferation, metastasis, progression, stemness, and the tumor microenvironment, as well as the underlying molecular mechanisms. The therapeutic advances in targeting GABA receptors for cancer treatment, particularly immunotherapy, are also discussed.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Alok K. Mishra, Shahid Banday, Ravi Bharadwaj, Amjad Ali, Romana Rashid, Ankur Kulshreshtha, Sunil K. Malonia
Summary: The revolution in cancer immunotherapy has resulted in a paradigm shift in cancer care, with a focus on targeting the components of the adaptive immune system. However, recent developments have recognized the efficacy of targeting the innate immune system, including macrophages, in solid cancer treatment. This review provides an overview of the role of tumor-associated macrophages (TAMs) in solid malignancies and discusses potential therapeutic strategies for targeting TAMs in next-generation immunotherapy.
Review
Oncology
Chao Yin, Monika Kulasekaran, Tina Roy, Brennan Decker, Sonja Alexander, Mathew Margolis, Reena C. Jha, Gary M. Kupfer, Aiwu R. He
Summary: Biliary tract cancers are rare but deadly gastrointestinal tumors that are often diagnosed at advanced stages. Chemotherapies have limited effectiveness, so there is a need for new treatments. This review explores the use of PARP inhibitors in treating biliary tract cancers and discusses expanding patient eligibility and the potential use of reliable HRD surrogate markers.
Article
Chemistry, Analytical
Anna Blsakova, Filip Kveton, Lenka Lorencova, Ola Blixt, Alica Vikartovska, Peter Kasak, Jan Tkac
Summary: This study presents the development of a novel SUspension Magnetic-Bead-based Assay (SUMBA) for the detection of antibodies against aberrant glycans (AGA) as potential cancer biomarkers. The SUMBA method was extensively optimised to achieve ultrasensitive detection of AGA with high recovery rates in serum samples.
ANALYTICA CHIMICA ACTA
(2022)
Review
Genetics & Heredity
Li Tao, Xiao Liu, Xinya Jiang, Kun Zhang, Yijing Wang, Xiumin Li, Shulong Jiang, Tao Han
Summary: This review summarizes the dual role of deubiquitinating enzyme USP10 in human cancers as well as its downstream substrates and upstream regulators. Additionally, it provides an overview of multiple pharmacological USP10 inhibitors and proposes the development of specific and efficient USP10 inhibitors as a promising therapeutic strategy for cancer treatment.
Review
Oncology
Liya Zhu, Xiu Juan Li, Prakash Gangadaran, Xiuli Jing, Byeong-Cheol Ahn
Summary: Macrophages play a significant role in the tumor microenvironment and have dual effects on the development of thyroid cancer. M1-like macrophages have cytotoxic effects on tumor cells and activate immune cells in the early stages of cancer, while M2-like macrophages promote tumor progression.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Immunology
Jing-Yan Cheng, Jung-Tung Hung, Juway Lin, Fei-Yun Lo, Jing-Rong Huang, Shih-Pin Chiou, Ya-Hui Wang, Ruey-Jen Lin, Jen-Chine Wu, John Yu, Alice L. Yu
Summary: OAcGD2 is a novel marker for breast cancer stem cells, and treatment with anti-OAcGD2 mAb8B6 can suppress tumor growth and reduce cancer metastasis and recurrence.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yan Chang, Souvik Roy, Zui Pan
Summary: The review discusses the impact of dysregulated store-operated calcium entry (SOCE) on gastroesophageal cancers, including its role in cancer cell proliferation, migration, invasion, and stemness maintenance. Efforts towards developing more specific and potent SOCE inhibitors as a new set of chemotherapeutic drugs for targeted therapy or adjuvant treatment to overcome drug resistance in gastroesophageal cancers are also highlighted.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Maclaine Parish, Gaelle Massoud, Dana Hazimeh, James Segars, Md Soriful Islam
Summary: This review summarizes the role of green tea in treating gynecological cancers. It examines the chemical and chemopreventive properties of green tea and presents the findings of studies on the effect of green tea on reproductive cancers. The potential benefits of using green tea as a therapeutic strategy for managing female reproductive cancers are discussed.
Article
Oncology
Elena Levantini, Giorgia Maroni, Marzia Del Re, Daniel G. Tenen
Summary: EGFR plays an important role in maintaining epithelial tissues, but when its signaling is altered, it becomes a major regulator of epithelial transformation and is one of the most studied tyrosine kinase receptors involved in neoplasia worldwide. EGFR-targeted therapies have revolutionized cancer treatment, but the dream of turning solid tumors into chronic diseases remains unfulfilled.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Jonathan So, Nathaniel W. Mabe, Bernhard Englinger, Kin-Hoe Chow, Sydney M. Moyer, Smitha Yerrum, Maria C. Trissal, Joana G. Marques, Jason J. Kwon, Brian Shim, Sangita Pal, Eshini Panditharatna, Thomas Quinn, Daniel A. Schaefer, Daeun Jeong, David L. Mayhew, Justin Hwang, Rameen Beroukhim, Keith L. Ligon, Kimberly Stegmaier, Mariella G. Filbin, William C. Hahn
Summary: Collateral lethality occurs when loss of a gene/protein renders cancer cells dependent on its remaining paralog. This study identified VRK1 as a synthetic lethal target in VRK2 promoter-methylated adult and pediatric gliomas and neuroblastomas. Depletion of VRK1 led to DNA damage and apoptosis due to reduced phosphorylation of the barrier-to-autointegration factor during mitosis.
Article
Oncology
Monica Niger, Federico Nichetti, Andrea Casadei-Gardini, Federica Morano, Chiara Pircher, Elena Tamborini, Federica Perrone, Matteo Canale, Daniel B. Lipka, Andrea Vingiani, Luca Agnelli, Anna Dobberkau, Jennifer Huellein, Felix Korell, Christoph E. Heilig, Sara Pusceddu, Francesca Corti, Michele Droz, Paola Ulivi, Michele Prisciandaro, Maria Antista, Marta Bini, Laura Cattaneo, Massimo Milione, Hanno Glimm, Bruno C. Koehler, Giancarlo Pruneri, Daniel Huebschmann, Stefan Froehling, Vincenzo Mazzaferro, Filippo Pietrantonio, Maria Di Bartolomeo, Filippo de Braud
Summary: This study investigated the impact of O-6-methylguanine-DNA methyltransferase (MGMT) inactivation in biliary tract cancers (BTCs). The results showed that MGMT inactivation is common in BTC and is associated with poor prognosis. This provides a theoretical basis for exploring DNA-damaging agents for the treatment of MGMT-inactivated BTC.
MOLECULAR ONCOLOGY
(2022)
