Article
Cardiac & Cardiovascular Systems
Joanna Sulicka-Grodzicka, Piotr Szczepaniak, Ewelina Jozefczuk, Karol Urbanski, Mateusz Siedlinski, Lukasz Niewiara, Bartlomiej Guzik, Grzegorz Filip, Boguslaw Kapelak, Karol Wierzbicki, Mariusz Korkosz, Tomasz J. Guzik, Tomasz P. Mikolajczyk
Summary: This study found that peripheral inflammatory cytokine measurements may not reflect local vascular inflammation or oxidative stress in patients with advanced cardiovascular disease (CVD). Circulating pro-inflammatory cytokines generally correlated positively with each other, similarly their mRNA correlated in the arterial wall, however, these levels were not correlated between the studied compartments.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ali Rafiei, Gordon A. Ferns, Reza Ahmadi, Arsalan Khaledifar, Tina Rahimzadeh-Fallah, Mina Mohmmad-Rezaei, Shohreh Emami, Nader Bagheri
Summary: Atherosclerosis is a chronic inflammatory disease with high mortality worldwide. MiR-27a and miR-329 expression levels, as well as serum levels of hs-CRP, ox-LDL, and MDA, were significantly higher in CAD patients compared to controls, while ABCA1 and ABCG1 gene expression was lower. Levels of hs-CRP, ox-LDL, and miR-27a were inversely related to ABCA1 and ABCG1 expression in all subjects.
Article
Health Care Sciences & Services
Jong-Suk Park, Zsolt Murlasits, Sangho Kim
Summary: The aim of this study was to investigate the impact of sleep deficiency on oxidative stress, hs-CRP and cortisol levels, and to examine the effects of different intensities of aerobic exercise on these parameters under sleep deficiency conditions. The results suggest that low-intensity aerobic exercise is the most effective in mitigating the negative effects of sleep deficiency.
Article
Medicine, General & Internal
Rahib K. Islam, Erinn Donnelly, Kazi N. Islam
Summary: HIV patients exhibit increased oxidative stress, decreased antioxidant levels, elevated cardiovascular disease biomarkers, and reduced levels of cardioprotective gaseous signaling molecules, nitric oxide and hydrogen sulfide. These alterations may contribute to the pathogenesis of cardiovascular disease in HIV patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Chemistry, Medicinal
Armita Mahdavi Gorabi, Mitra Abbasifard, Danyal Imani, Saeed Aslani, Bahman Razi, Shahab Alizadeh, Zahra Bagheri-Hosseinabadi, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Curcumin supplementation has been shown to significantly reduce CRP and hs-CRP levels, with a stronger effect observed at doses <= 1,000 mg/day and interventions lasting <= 10 weeks. A non-linear reduction in hs-CRP was seen with curcumin consumption, especially at doses below 2,000 mg/day. Overall, curcumin appears beneficial in decreasing inflammatory markers such as hs-CRP and CRP.
PHYTOTHERAPY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Julia Matuszewska, Tomasz Zalewski, Adam Klimaszyk, Kamil Ziarniak, Stefan Jurga, Agata Chmurzynska, Joanna H. Sliwowska
Summary: The study found that maternal consumption of a CAF diet affects fat content, metabolic profiles, and inflammation parameters in offspring, with these effects being sex-specific, with female offspring being more susceptible to the diet.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Paul M. Haller, Alina Gossling, Christina Magnussen, Hermann Brenner, Ben Schoettker, Licia Iacoviello, Simona Costanzo, Frank Kee, Wolfgang Koenig, Allan Linneberg, Chaterina Sujana, Barbara Thorand, Veikko Salomaa, Teemu J. Niiranen, Stefan Soederberg, Henry Voelzke, Marcus Doerr, Susana Sans, Teresa Padro, Stephan B. Felix, Matthias Nauck, Astrid Petersmann, Luigi Palmieri, Chiara Donfrancesco, Roberto De Ponti, Giovanni Veronesi, Marco M. Ferrario, Kari Kuulasmaa, Tanja Zeller, Francisco M. Ojeda, Stefan Blankenberg, Dirk Westermann
Summary: This study demonstrates the role of cardiac biomarkers in predicting cardiovascular events and death in both general population and individuals with known diabetes. The findings suggest that these biomarkers can help identify individuals at highest risk for cardiovascular events and improve early identification of high-risk individuals. Therefore, they should be considered for routine risk assessment and can enhance the initiation of preventive therapies.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elaheh Rabbani, Fatemeh Golgiri, Leila Janani, Nariman Moradi, Soudabeh Fallah, Behnaz Abiri, Mohammadreza Vafa
Summary: Supplementation with zinc, magnesium, and vitamin A can improve thyroid function, reduce oxidative stress, and lower hs-CRP levels in patients with hypothyroidism.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Miljana Z. Jovandaric, Sandra Babic, Misela Raus, Biljana Medjo
Summary: Metabolic changes in pregnant women, influenced by placental hormones, affect the metabolism of nutrients. Pregnancy is accompanied by increased lipid concentration and the accumulation of triglycerides in low-density lipoproteins (LDL) particles. Oxidative stress due to excessive production of free oxygen radicals plays a significant role in the pathogenesis of complications during pregnancy. The altered lipid profile and oxidative stress in pregnant women increase the risk of premature birth and pregnancy-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Disha Rao, Fabienne Verburg, Kathrin Renner, Daniel S. Peeper, Ruben Lacroix, Christian U. Blank
Summary: Metabolic reprogramming in cancer cells leads to the formation of a tumour microenvironment characterized by nutrient restriction, hypoxia, acidity, and oxidative stress, unfavorable for effector T cells but conducive for immune-suppressive functions of Tregs. Tregs rely on oxidative phosphorylation for their functions and have metabolic adaptations in the tumour microenvironment. Targeting pathways responsible for Tregs' adaptation in the tumour microenvironment can improve anti-tumour immunity in preclinical models.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Mengmeng Song, Tong Liu, Hai Liu, Qi Zhang, Qingsong Zhang, Yiming Wang, Xiangming Ma, Liying Cao, Hanping Shi
Summary: The co-occurrence of MetS and high hs-CRP levels is associated with an elevated risk of PLC.
Article
Agriculture, Dairy & Animal Science
Arletta Bielecka, Monika Jamiol, Marta Kankofer
Summary: The study investigated the influence of metabolic state on the effectiveness of antioxidant profiles in plasma and saliva during cow pregnancy, showing dynamic changes depending on the period of pregnancy course. Saliva partly reflects plasma content due to local metabolism, highlighting the need for further research to establish physiological ranges of antioxidative/oxidative profiles in cows.
Article
Food Science & Technology
Davood Soleimani, Seyedeh Parisa Moosavian, Hamid Zolfaghari, Zamzam Paknahad
Summary: This study aimed to evaluate the effects of garlic on blood pressure and hs-CRP among NAFLD patients. The results showed significant reductions in blood pressure and hs-CRP in the garlic group, with a positive correlation between changes in hs-CRP and blood pressure.
FOOD SCIENCE & NUTRITION
(2021)
Article
Nutrition & Dietetics
Mi Joung Kim, In Woo Kim
Summary: The study found that self-rated health is related to metabolic syndrome and high-sensitivity C-reactive protein levels, and can serve as an independent predictor in healthy adults for the development of a health promotion program.
NUTRITION RESEARCH
(2022)
Article
Nutrition & Dietetics
Adela Kabelova, Hana Malinska, Irena Markova, Olena Oliyarnyk, Blanka Chylikova, Ondrej Seda
Summary: Ellagic acid, a natural substance found in fruits and nuts, has beneficial effects on metabolic syndrome by lowering oxidative stress levels and improving characteristics of brown adipose tissue.
Review
Biochemistry & Molecular Biology
Masomeh Maleki, Asal Golchin, Samira Javadi, Nafiseh Khelghati, Pejman Morovat, Zatollah Asemi, Forough Alemi, Mostafa Vaghari-Tabari, Bahman Yousefi, Maryam Majidinia
Summary: Exosomal miRNA plays an important role in the chemo-resistance, diagnosis, and prognosis of colorectal cancer (CRC). Engineered exosomes can deliver functional miRNAs to reverse chemoresistance and serve as promising biomarkers for CRC.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Review
Food Science & Technology
Mostafa Vaghari-Tabari, Iraj Mohammadzadeh, Durdi Qujeq, Maryam Majidinia, Forough Alemi, Simin Younesi, Ata Mahmoodpoor, Masomeh Maleki, Bahman Yousefi, Zatollah Asemi
Summary: Respiratory viral infections are common and unregulated immune response can cause inflammation and tissue damage. Regulating the antiviral immune response in the respiratory tract is important. Recent studies highlight the importance of vitamin D in respiratory viral infections. Vitamin D, in addition to regulating phosphorus and calcium metabolism, can also regulate immune response, providing protection against respiratory viral infections and preventing excessive inflammation and tissue damage.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Faezeh Malakoti, Niloufar Targhazeh, Haniye Karimzadeh, Erfan Mohammadi, Milad Asadi, Zatollah Asemi, Forough Alemi
Summary: This article reviews the effects of lncRNA MALAT1 on the progression of six prevalent human cancers, focusing on its ability to regulate post-transcriptional modification and signaling pathways.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Review
Food Science & Technology
Mina Homayoonfal, Zatollah Asemi, Bahman Yousefi
Summary: Despite progress in cancer therapy, global cancer prevalence and mortality rates continue to rise. Long non-coding RNAs (lncRNAs) play undeniable roles in the incidence and development of various cancers. Phytochemicals have the potential to regulate lncRNAs and can be used as innovative approaches for cancer treatment and prevention.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Chemistry, Medicinal
Rana Shafabakhsh, Russel J. Reiter, Michael Aschner, Hamed Mirzaei, Zatollah Asemi
Summary: Globally, cervical cancer is the second most common cancer and the third main cause of death related to cancer in women. Chronic infection with human papilloma virus (HPV) can trigger cervical cancer by an interplay of various pathways and molecules. Cervical carcinoma is treatable in the early stages but poorly manageable at advanced stages, necessitating the identification of new therapeutic platforms. Resveratrol, a herb-based component, has shown anti-cancer activities and could have potential as a therapeutic agent for cervical cancer.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Review
Food Science & Technology
Lei Yan, Mostafa Vaghari-Tabari, Faezeh Malakoti, Soheila Moein, Durdi Qujeq, Bahman Yousefi, Zatollah Asemi
Summary: Various studies have shown that quercetin has beneficial therapeutic effects in various human diseases, including diabetes. Quercetin has significant anti-diabetic effects and may be helpful in lowering blood sugar and increasing insulin sensitivity. It also has positive effects in preventing and ameliorating diabetic complications, possibly due to its anti-inflammatory and anti-oxidant properties.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Raziyeh Salami, Marziyeh Salami, Alireza Mafi, Mohammad-Hossein Aarabi, Omid Vakili, Zatollah Asemi
Summary: The increasing prevalence of diabetes mellitus and related diseases has raised concerns globally. Controlling blood glucose levels is crucial in preventing and slowing down the development of diabetes-related complications. Incretins, gut-derived hormones, have been extensively used to treat type 2 diabetes mellitus. This review investigates the mechanisms and signaling pathways associated with the antidiabetic effects of incretins, and summarizes the outcomes of clinical trials evaluating their potential in diabetic patients.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Correction
Biochemistry & Molecular Biology
Maryam Maktabi, Mehri Jamilian, Zatollah Asemi
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Retraction
Biochemistry & Molecular Biology
Zahra Heidarzadeh, Mansooreh Samimi, Seyed Morteza Seifati, Mahmood Dehghani Ashkezari, Shahnaz Ahmadi, Samaneh Mahmoodi, Esmat Aghadavod, Mehri Jamilian, Zatollah Asemi
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Oncology
Amirhossein Davoodvandi, Sahand Sadeghi, Seyed Mohammad Amin Alavi, Seyedeh Shaghayegh Alavi, Ameneh Jafari, Haroon Khan, Michael Aschner, Hamed Mirzaei, Mehran Sharifi, Zatollah Asemi
Summary: Cancer is a serious health issue and drug therapy is commonly used for treatment. There is increasing interest in using natural compounds to overcome drug resistance and adverse reactions in cancer treatment. One such compound is berberine, which has a wide range of pharmacological activities and has shown anticancer effects on various gastrointestinal cancers. In this article, the therapeutic effects of berberine and its mechanisms on esophageal, gastric, colorectal, hepatocarcinoma, and pancreatic cancers are summarized.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Medicine, Research & Experimental
Seyed Mohammad Reza Hashemian, Amirhossein Sheida, Mohammad Taghizadieh, Mohammad Yousef Memar, Michael R. Hamblin, Hossein Bannazadeh Baghi, Javid Sadri Nahand, Zatollah Asemi, Hamed Mirzaei
Summary: Due to the lack of effective therapies for COVID-19, patients have to rely on supportive and nonspecific treatments. Certain proteins of SARS-CoV-2, such as 3 C-like protease (3CLpro) and major protease (Mpro), have been identified as potential targets for antiviral drugs. Nirmatrelvir, combined with ritonavir, has shown potent antiviral activity against SARS-CoV-2 variants, but there are still uncertainties regarding their efficacy, safety, and side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Alireza Mafi, Malihe Rezaee, Neda Hedayati, Sara Diana Hogan, Russel J. Reiter, Mohammad-Hossein Aarabi, Zatollah Asemi
Summary: Combined chemotherapy is an effective treatment for cancer patients, as it combines multiple therapeutic agents to target different aspects of cancer. 5-FU is a widely used chemotherapy agent, while melatonin has shown anti-cancer properties. This review aims to evaluate the role of melatonin as a complementary agent with 5-FU-based chemotherapy and identify their common signaling pathways.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Pathology
Mehran Sharifi, Nesa Rajabpoor Nikoo, Bita Badehnoosh, Rana Shafabakhsh, Reza Asemi, Russel J. Reiter, Zatollah Asemi
Summary: Endometriosis is a serious disease in women that has a significant financial burden similar to diabetes mellitus globally. It is associated with pelvic pain, decreased quality of life, and reduced work efficiency, as well as various clinical consequences including mood complaints and increased risks of inflammation, metabolic impairments, immunologic problems, and malignancies. Melatonin, a natural molecule with antioxidant and anti-inflammatory properties, has shown potential in limiting endometriosis by inhibiting proliferation, reducing oxidative stress and inflammation, inducing apoptosis, and inhibiting the growth of endometriotic tissue. However, further clinical trials are needed to confirm its efficacy.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Chemistry, Medicinal
Omid Reza Tamtaji, Reza Heidari-soureshjani, Zatollah Asemi, Ebrahim Kouchaki
Summary: The study aimed to investigate the effects of spirulina intake on cognitive function and metabolic status in patients with Alzheimer's disease (AD). A randomized, double-blind, controlled clinical trial was conducted involving 60 AD patients. The results showed that spirulina intake for 12 weeks significantly improved cognitive function and glucose homeostasis, while reducing high-sensitivity C-reactive protein levels. These findings suggest that spirulina may have beneficial effects in AD patients.
PHYTOTHERAPY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Alireza Mafi, Atoosa Keshavarzmotamed, Neda Hedayati, Zahra Yeganeh Boroujeni, Russel J. Reiter, Rohollah Mousavi Dehmordi, Mohammad Hossein Aarabi, Malihe Rezaee, Zatollah Asemi
Summary: Despite being mainly known as a regulator of circadian rhythm, melatonin has been found to play a notable role in other fundamental biological processes. It has been shown to have an inhibitory effect on tumor development, making it a potential adjunct agent for cancer treatment. In addition, melatonin has been found to impact the expression of non-coding RNAs (ncRNAs) in various disorders, including cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
