Article
Oncology
Huei-Jean Huang, Hsiu-Jung Tung, Lan-Yan Yang, Angel Chao, Yun-Hsin Tang, Hung-Hsueh Chou, Wei-Yang Chang, Ren-Chin Wu, Chu-Chun Huang, Chiao-Yun Lin, Min-Jie Liao, Wei-Chun Chen, Cheng-Tao Lin, Min-Yu Chen, Kuan-Gen Huang, Chin-Jung Wang, Ting-Chang Chang, Chyong-Huey Lai
Summary: This observational study investigated the long-term outcomes and HPV genotype changes after conization for high-grade cervical intraepithelial neoplasia (HG-CIN). Results showed that active surveillance may reduce the severity of progression to cancer, and a majority of patients with recurrent CIN2+ had persistent type-specific HPV infections. Effective therapeutic vaccines for such cases are still needed.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Qing Cong, Yi Yu, Yu Xie, Yanyun Li, Long Sui
Summary: This study aims to determine the reasonable and optimal conization length for different types of cervical transformation zones (TZs) in order to achieve negative margin outcomes in surgery. The results show that a conization length of 10-15 mm is reasonable for TZ1 and TZ2 patients, while 17-25 mm is optimal for TZ3 patients to obtain more negative internal margins.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Nae Ry Kim, Zee Hae Baek, A. Jin Lee, Eun Jung Yang, Yung-Taek Ouh, Mi Kyung Kim, Seung-Hyuk Shim, Sun Joo Lee, Tae Jin Kim, Kyeong A. So
Summary: The study found that although there were no significant differences in residual disease and CIN recurrence between the GI-negative and GI-positive groups, GI-positive patients were more likely to receive additional surgical treatments. Careful consideration should be given to repeat surgery based on GI positivity to avoid overtreatment and surgical complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Andrea Ciavattini, Jacopo Di Giuseppe, Chiara Marconi, Luca Giannella, Giovanni Delli Carpini, Michela Paolucci, Mariasole Fichera, Rosa Pasqualina De Vincenzo, Giovanni Scambia, Maria Teresa Evangelista, Giorgio Bogani, Francesca Bertolina, Francesco Raspagliesi, Barbara Gardella, Arsenio Spinillo, Mattia Dominoni, Ermelinda Monti, Carlo Antonio Liverani, Paolo Vercellini, Maria Iorio, Domenico Vitobello, Rosalba Portuesi, Gianluigi Bresciani, Massimo Origoni, Francesco Cantatore, Antonio Maurizio Pellegri, Lorenzo Moriconi, Matteo Serri, Andrea Chiari, Francesco Sopracordevole, Maggiorino Barbero, Fabio Parazzini
Summary: There has been a significant increase in the number of hysterectomies performed for CIN in the past decade. However, this procedure carries risks of complications, the onset of vaginal lesions, and overtreatment, which highlights the importance of proper counseling before making a decision.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Malene Skorstengaard, Petra Hall Viborg, Ane Birgitte Telen Andersen, Berit Andersen, Mary Holten Bennetsen, Kirsten Marie Jochumsen, Tonje Johansen, Lise Grupe Larsen, Maja Ulrikka Bruun Laustsen, Rouzbeh Salmani, Reza Serizawa, Marianne Waldstrom, Elsebeth Lynge
Summary: This study assessed the outcomes of a one-time HPV screening in Danish women aged 70+. The study found that the prevalence of high-risk HPV in women aged 70-74 was 4.3%, and there were 5 cases of CIN2+ detected per 1000 screened women, with a recommended treatment threshold of CIN2.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Qing Wu, Yu Jiang, Jun Ding, Lihua Xia, Haiou Xu
Summary: This study investigated the predictors of residual disease in patients who underwent a hysterectomy following a LEEP for CIN 3. The results revealed that positive ECC, positive margin of LEEP samples, type III transformation zone, and HPV18 infection were reliable prognostic markers of residual disease.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Review
Immunology
Violante Di Donato, Giuseppe Caruso, Marco Petrillo, Evangelos Kontopantelis, Innocenza Palaia, Giorgia Perniola, Francesco Plotti, Roberto Angioli, Ludovico Muzii, Pierluigi Benedetti Panici, Giorgio Bogani
Summary: This meta-analysis demonstrated that adjuvant HPV vaccination is associated with a reduced risk of recurrent CIN 1+ and CIN 2+ after surgical treatment, based on the analysis of 11 selected studies.
Article
Oncology
Mingzhu Li, Chao Zhao, Yun Zhao, Jingran Li, Jingyuan Wang, Hongxue Luo, Zhijian Tang, Yan Guo, Lihui Wei
Summary: Objective: To investigate the predictive ability of PAX1 methylation (PAX1(m)) for the pathological upgrade of cervical intraepithelial neoplasia (CIN) before cold knife conization (CKC). Results: PAX1(m) was found to be a potential auxiliary marker in predicting the pathological upgrade of CIN.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Mingyu Jia, Chong Lan, Jumin Niu, Yin Liang
Summary: This study investigated the risk factors for pathological upgrading in conization specimens in Chinese women with Cervical Intraepithelial Neoplasia grade 2/3 (CIN2/3) aged 50 and above. Factors associated with upgrading included postmenopausal period >= 5 years, EGI, endocervical curettage, and HPV type 16/18.
Article
Oncology
Fl Sand, Kirsten Frederiksen, Susanne K. Kjaer
Summary: This study investigates the relationship between post-conization HPV status and surgical margins and the absolute risk of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). The results suggest that considering both HPV status and margin in risk assessment provides additional stratification compared to HPV status alone. Combined testing with HPV and margin status has higher sensitivity but lower specificity than HPV testing alone, which is important in high-risk populations.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Medicine, General & Internal
Yan Ge, Yongli Liu, Yun Cheng, Yanbo Liu
Summary: This study identified factors predicting recurrence in patients with high-grade CIN after cervical conization. Positive margins, histories of preterm birth, and complicating diseases were associated with increased risk of recurrence, while cone depth (>0.5 cm) was linked to lower recurrence risk.
Article
Virology
Daisuke Tamura, Wataru Sako, Rina Watanabe, Akihiro Shitara, Fumiko Saito, Misa Yamauchi, Akihiro Sugita, Akihiro Karube
Summary: In this retrospective cohort study, we found that the quantitatively measured area of CIN2/3 was closely associated with patient age, high-risk HPV status, especially single HPV16 infection, and uterine position.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Obstetrics & Gynecology
Alberto Agarossi, Giovanni Delli Carpini, Francesco Sopracordevole, Matteo Serri, Luca Giannella, Barbara Gardella, Marta Maestri, Anna Del Fabro, Matilde Sansone, Maria Grazia Fallani, Annalisa Pieralli, Maria Michela Fasolo, Cristina Mazzali, Andrea Ciavattini
Summary: This study found that HR-HPV positivity is a risk factor for recurrence after cervical excision in WLWH, while age older than 41 years is a risk factor for HR-HPV positivity. Therefore, women over 41 may benefit from more frequent follow-up visits. Future studies on HPV vaccination after treatment in WLWH may also be beneficial.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Ting Ding, Lin Li, Ruiqi Duan, Yun Chen, Bowen Yang, Mingrong Xi
Summary: This retrospective study evaluated the risk factors for recurrent high-grade cervical intraepithelial neoplasia after loop electrosurgical excision procedure (LEEP). High-risk HPV infection, margin status, baseline diagnosis, smoking, and immunosuppression were identified as significant independent risk factors for recurrence. HPV genotypes were associated with higher risk of recurrence.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Putora Katharina, Hornung Rene, Kinkel Janis, Fischer Tina, Putora Paul Martin
Summary: This study aimed to investigate guidelines on preterm birth, analyze decision-criteria, and identify consensus and discrepancies among these guidelines. The results showed that a shortened cervix and a history of preterm birth are relevant in singleton pregnancies. Most guidelines recommend progesterone treatment for cases with no history of preterm birth and with a shortened cervix.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Noa Grinberg, Reut Rotem, Hagit Diamant, Moshe Barg, Boaz Sheizaf, David Yohai, Adi Y. Weintraub
Summary: The study found no significant differences in the clinical presentation and microbiological features between pregnant patients with Bartholin gland abscess and nonpregnant patients. However, a significantly higher recurrence rate was noted in pregnant patients, although no adverse perinatal outcomes were observed.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Reut Rotem, Shira Bitensky, Gali Pariente, Ruslan Sergienko, Misgav Rottenstreich, Adi Y. Weintraub
Summary: The study found that prior cesarean delivery (CD) in the second stage of labor (non-progressive labor in the second stage - NPL2) is associated with a higher risk of third stage placental complications in the subsequent delivery compared to CD in the first stage of labor (NPL1). Parturients following CD due to NPL2 had significantly higher rates of manual removal of the placenta and adherent placenta in the subsequent delivery. Additionally, adherent placenta was independently associated with vaginal delivery following CD due to NPL2.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Ranit Hizkiyahu, Yael Baumfeld, Dorit Paz Levy, Talya Lanxner Battat, Majdi Imterat, Adi Y. Weintraub
Summary: This study found no association between vaginal Candida colonization during pregnancy and an increased risk of obstetrical tears.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Alla Saban, Ilana Shoham-Vardi, David Yohay, Adi Y. Weintraub
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2020)
Article
Obstetrics & Gynecology
Roy Kessous, Emad Matanes, Ido Laskov, Tamar Wainstock, Jeremie Abitbol, Amber Yasmeen, Shannon Salvador, Susie Lau, Walter H. Gotlieb
Summary: The study showed that patients with advanced ovarian cancer who received dose-dense weekly paclitaxel had significantly better progression-free survival compared to those who received standard 3-weekly chemotherapy. Although the overall survival was also better in the dose-dense group, the difference was not statistically significant. The dose-dense protocol was associated with higher rates of side effects but may be considered as a treatment alternative for advanced ovarian cancer patients.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Oncology
Roy Kessous, Michel D. Wissing, Ido Laskov, Jeremie Abitbol, Joanna Bitharas, Venkata R. Agnihotram, Amber Yasmeen, Shannon Salvador, Susie Lau, Walter H. Gotlieb
Summary: The study found that as the number of treatment lines increased, the response rate of ovarian cancer patients decreased, with most patients becoming refractory. The time interval from the previous line of chemotherapy was identified as the major clinical factor that predicts the beneficial effect of another line of treatment for patients with ovarian cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Obstetrics & Gynecology
Shira Bitensky, Gali Pariente, Reut Rotem, Ruslan Sergienko, Adi Yehuda Weintraub
Summary: This study found that women with prior cesarean delivery due to first stage non-progressive labor are more likely to develop hypertensive disorders of pregnancy and have a repeated cesarean delivery in subsequent pregnancies, while those with prior cesarean delivery due to second stage non-progressive labor are more likely to experience preterm birth in subsequent pregnancies.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Ella Pardo, Reut Rotem, Hannah Glinter, Miriam Erenberg, Lior Yahav, Zehava Yohay, David Yohay, Adi Y. Weintraub
Summary: This study aimed to evaluate the correlation between PFD symptoms during pregnancy and the duration of the SSL. By analyzing data from 200 women, it was found that there is a correlation between PFD symptoms during pregnancy and the duration of the SSL.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Yael Levine, Lior Yahav, Polina Schwarzman, David Yohai, Reli Hershkovitz, Adi Y. Weintraub
Summary: The study found a significant inverse association between endometrial thickness and MTX treatment criteria for ectopic pregnancy, with thicker endometrium being correlated with lower success rates of MTX treatment. This may serve as a useful tool in treatment selection for ectopic pregnancy.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Surgery
Miriam Erenberg, Reut Rotem, David Segal, Zehava Yohay, Inbal Idan, David Yohay, Adi Y. Weintraub
Summary: The study found that the use of adhesion barriers and hemostatic agents were independently associated with post-cesarean section infections. Further larger studies are needed to reinforce these findings, and careful consideration should be given to the use of these materials, re-evaluating their cost-effectiveness.
Article
Obstetrics & Gynecology
Elihai Haviv, Polina Schwarzman, Eli H. Bernstein, Tamar Wainstock, Adi Y. Weintraub, Elad Leron, Offer Erez
Summary: Open myomectomy is associated with a higher rate of cesarean delivery compared to laparoscopic myomectomy, with no significant differences noted between the two types of surgery in terms of other outcomes. No severe adverse maternal or neonatal outcomes were detected during the study.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Roy Kessous, Eyal Sheiner, Guy Beck Rosen, Joseph Kapelushnik, Tamar Wainstock
Summary: The study aimed to evaluate whether children born small for gestational age (SGA) have an increased risk for childhood neoplasms. The results showed that SGA children had a higher incidence of lymphoma, highlighting the long-term impact of being born SGA on the risk for childhood lymphoma.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Jan A. Deprest, Rufus Cartwright, Hans Peter Dietz, Luiz Gustavo Oliveira Brito, Marianne Koch, Kristina Allen-Brady, Jittima Manonai, Adi Y. Weintraub, John W. F. Chua, Romana Cuffolo, Felice Sorrentino, Laura Cattani, Judith Decoene, Anne-Sophie Page, Natalie Weeg, Glaucia M. Varella Pereira, Marina Gabriela M. C. Mori da Cunha de Carvalho, Katerina Mackova, Lucie Hajkova Hympanova, Pamela Moalli, Oksana Shynlova, Marianna Alperin, Maria Augusta T. Bortolini
Summary: Genetics, vaginal birth, and age are strongly etiologically linked to the development of pelvic organ prolapse (POP), while other factors may contribute to or protect against the risk.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Article
Multidisciplinary Sciences
Tamar Matyashov, Ella Pardo, Reut Rotem, Yael Lichtman, Maayan Elnir Katz, Adi Y. Weintraub, Amir Horev
Summary: The study found no significant association between striae gravidarum and perineal tears. This information can provide reassurance to pregnant women with striae gravidarum during antepartum consultations, even in severe cases.
Article
Medicine, General & Internal
Tal Shabtai, Eyal Sheiner, Tamar Wainstock, Arie Raziel, Roy Kessous
Summary: This study aimed to investigate the risk of childhood malignancy in twins conceived following infertility treatments. By comparing twins conceived by infertility treatments and those conceived spontaneously, a population-based retrospective cohort study found no significant differences in the rate and cumulative incidence of childhood malignancies between the two groups during the study period.
JOURNAL OF CLINICAL MEDICINE
(2023)
