Article
Cardiac & Cardiovascular Systems
Cristina Trilla, Cristina Luna, Silvia De Leon Socorro, Leire Rodriguez, Aina Ruiz-Romero, Josefina Mora Brugues, Taysa Benitez Delgado, Marta Fabre, Alicia Martin Martinez, Sara Ruiz-Martinez, Elisa Llurba, Daniel Oros
Summary: This study aims to determine the predictive and preventive capacity of a universal first-trimester screening model for preeclampsia by determining PlGF levels in intermediate-risk patients. The screening model is expected to achieve similar diagnostic performance as universal determination of PlGF but at a lower economic cost.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Sylwia Slawek-Szmyt, Katarzyna Kawka-Paciorkowska, Aleksandra Cieplucha, Maciej Lesiak, Mariola Ropacka-Lesiak
Summary: Cardiovascular diseases (CVDs) are the top cause of death in women worldwide. Traditional risk factors and pregnancy-related complications both impact a woman's future CVD risk. Some pregnancy complications and CVDs may share common pathophysiological pathways.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Erika Bonacina, Manel Mendoza, Alba Farras, Pablo Garcia-Manau, Berta Serrano, Ivan Hurtado, Raquel Ferrer-Oliveras, Lidia Illan, Mireia Armengol-Alsina, Elena Carreras
Summary: In early-onset SGA and FGR, the sFlt-1/PlGF values can predict the time to delivery and may be used for planning fetal surveillance by reducing ultrasound frequency in cases with sFlt-1/PlGF < 38 and providing closer follow-up in cases with sFlt-1/PlGF > 85.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Medicine, General & Internal
Daniel Boron, Jakub Kornacki, Ewa Wender-Ozegowska
Summary: Intima-media thickness (IMT) measurement is a non-invasive method to assess arterial wall, and it is associated with atherosclerosis and endothelial dysfunction. Pre-existing conditions like diabetes, chronic hypertension, and obesity may impair the adaptation to pregnancy and influence fetal IMT. Increased fetal abdominal aorta IMT (aIMT) has been correlated with placental dysfunctions, which may lead to gestational hypertension, preeclampsia, and fetal growth restriction. Understanding the underlying pathomechanism is crucial for developing targeted therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Piotr Tousty, Magda Fraszczyk-Tousty, Anna Golara, Adrianna Zahorowska, Michal Slawinski, Sylwia Dzidek, Hanna Jasiak-Jozwik, Magda Nawceniak-Balczerska, Agnieszka Kordek, Ewa Kwiatkowska, Aneta Cymbaluk-Ploska, Andrzej Torbe, Sebastian Kwiatkowski
Summary: This study aimed to evaluate the implementation of low-dose acetylsalicylic acid (ASA) for the prevention of pregnancy-induced hypertension (PE) and fetal growth restriction (FGR) in a Polish population. The results showed that patients in the high-risk group were more likely to experience complications during pregnancy, including pre-eclampsia, fetal growth restriction, gestational diabetes, and cesarean section. The conclusion is that the first-trimester screening is crucial in identifying high-risk pregnancies, and ASA prophylaxis may have the most beneficial effect on these high-risk patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu'uhevaha J. Kaitu'u-Lino, Susan P. Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Lisa Hui, Natalie J. Hannan
Summary: Elevated levels of OLAH in the placenta may be associated with placental dysfunction in pregnancies complicated by preterm preeclampsia and fetal growth restriction. Further research is required to understand the role of OLAH in the placenta, and whether these changes are a maternal adaptation or consequence of disease.
Article
Biochemistry & Molecular Biology
Kayo Tanaka, Hiroaki Tanaka, Ryota Tachibana, Kento Yoshikawa, Takuya Kawamura, Sho Takakura, Hiroki Takeuchi, Tomoaki Ikeda
Summary: This study aimed to investigate the effects of tadalafil as an intrauterine treatment for fetal growth restriction (FGR). The results showed that tadalafil improved placental mTOR signaling and facilitated fetal growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Lauren T. Gallagher, Clyde J. Wright, Tanner Lehmann, Ludmila Khailova, Miguel Zarate, Bailey D. Lyttle, Kenneth W. Liechty, S. Christopher Derderian
Summary: Fetal growth restriction (FGR) is associated with impaired angiogenesis and chronic inflammation. Dysregulation of miR-15b and miR-146a gene expression in FGR is linked to aberrant angiogenesis and chronic inflammation, respectively. These findings provide insights into possible therapeutic targets for FGR.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Obstetrics & Gynecology
Gabriel A. Arenas, Nga Y. Tang, Ariel Mueller, Joana Lopes Perdigao, Harjot Kaur, Jacques S. Abramowicz, Kathryn Mussatt, Kiang-Teck J. Yeo, Sarosh Rana
Summary: In patients with fetal growth restriction, the soluble fms-like tyrosine kinase-1 to placental growth factor ratio may serve as a potential biomarker for identifying at risk patients for developing preeclampsia and subsequently preterm delivery. This study found that patients with a high ratio had a greater proportion of preeclampsia diagnosis, higher rates of preterm delivery, smaller neonatal birthweight, and a shorter time to delivery from testing to delivery compared to patients with a low ratio.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)
Article
Medicine, General & Internal
Ciara N. Murphy, Catherine A. Cluver, Susan P. Walker, Emerson Keenan, Roxanne Hastie, Teresa M. MacDonald, Natalie J. Hannan, Fiona C. Brownfoot, Ping Cannon, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: This study is the first to demonstrate significantly reduced SPINT1 levels in pregnancies with co-existing FGR and preeclampsia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Xianglan Peng, Dong He, Rui Peng, Jianyang Feng, Dunjin Chen, Hongkai Xie, Qixuan Li, Yitong Guo, Jiaxiong Zhou, Yang Chen, Hong He
Summary: IGFBP1 gene single nucleotide polymorphism is associated with preeclampsia susceptibility. The GG or AG genotypes are associated with a decreased risk of preeclampsia. Women in the preeclampsia group with the G allele have higher fetal birth weight, lower diastolic blood pressure, and lower levels of ALT and AST. Rs1065780A>G raises the level of IGFBP1 protein in plasma and decidua in the preeclampsia group.
HYPERTENSION RESEARCH
(2023)
Article
Medicine, General & Internal
Jiao Yi, Lei Chen, Xianglian Meng, Yi Chen
Summary: This study aimed to identify factors affecting expectant management of early-onset preeclampsia and evaluate the correlation between expectant treatment and fetal growth restriction. The duration of 24-h proteinuria showed a negative correlation with expectant treatment, but expectant treatment could not improve the occurrence of fetal growth restriction.
ANNALS OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Eun Hui Joo, Young Ran Kim, Nari Kim, Jae Eun Jung, Seon Ha Han, Hee Young Cho
Summary: Oxidative stress, caused by the imbalance between ROS production and detoxification ability, is associated with pregnancy complications. Maintaining normal placental function and vascular network is crucial for a healthy pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jakub Staniczek, Maisa Manasar-Dyrbus, Agnieszka Drosdzol-Cop, Rafal Stojko
Summary: Beckwith-Wiedemann Syndrome (BWS) is an imprinting disorder characterized by overgrowth and susceptibility to embryonal tumors. The relationship between maternal complications such as HELLP syndrome and preeclampsia with the development of BWS in offspring is rarely documented. This case report highlights the complex nature of BWS and its potential association with maternal complications, as well as the atypical presence of fetal growth restriction and the absence of CDKN1C gene mutations in the newborn, which have not been previously reported in BWS cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Miguel A. Ortega, Oscar Fraile-Martinez, Cielo Garcia-Montero, Miguel A. Saez, Miguel Angel alvarez-Mon, Diego Torres-Carranza, Melchor alvarez-Mon, Julia Bujan, Natalio Garcia-Honduvilla, Coral Bravo, Luis G. Guijarro, Juan A. De Leon-Luis
Summary: The placenta is a crucial organ in pregnancy, with various functions. Understanding its development and role is essential for comprehending pregnancy and related diseases.
Article
Nutrition & Dietetics
Jessica Dawson, Martin Howell, Kirsten Howard, Katrina L. Campbell, Jonathan C. Craig, Allison Tong, Vincent W. Lee
Summary: An economic evaluation was conducted on a trial-based mobile phone text messaging intervention targeting dietary behaviors in hemodialysis patients, showing potential cost savings and improved dietary behaviors. Further larger-scale trials with longer follow-up are warranted.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Review
Obstetrics & Gynecology
Monica Zen, Rabbia Haider, David Simmons, Michael Peek, Christopher J. Nolan, Suja Padmanabhan, Shilpa Jesudason, Thushari Alahakoon, Ngai Wah Cheung, Vincent W. Lee
Summary: The effectiveness of aspirin prophylaxis for pre-eclampsia in women with pre-existing diabetes mellitus may be similar to those without diabetes mellitus. However, the current randomized data is insufficient, indicating a need for further studies in this high-risk group of women.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Article
Nursing
Sarah J. Melov, Nelma Galas, Julie Swain, Thushari Alahakoon, Vincent Lee, N. Wah Cheung, Terry McGee, Dharmintra Pasupathy, Justin McNab
Summary: This study investigated the impact of COVID-19 on maternity clinicians in a high-migrant population. The findings revealed that travel restrictions resulted in loss of important family support for migrant families, but partners often stepped up to fill the role of missing overseas relatives. In terms of clinical care, there was a shift towards prioritizing the health and safety of healthcare staff rather than optimizing patient care.
Article
Urology & Nephrology
Andrew Mallett, Phoebe Jane Kearey, Anne Cameron, Helen G. Healy, Charles Denaro, Mark Thomas, Vincent W. Lee, Samantha Louise Stark, Maria Fuller, Zaimin Wang, Wendy E. Hoy
Summary: The study found a prevalence rate of 0.2% for Fabry disease among CKD patients. Using a multi-tiered screening strategy, cases of FD can be identified in the CKD population.
Article
Medicine, General & Internal
Sarah J. Melov, James Elhindi, Therese M. McGee, Vincent W. Lee, N. Wah Cheung, Seng Chai Chua, Justin McNab, Thushari Alahakoon, Dharmintra Pasupathy
Summary: This study investigated the impact of the COVID-19 pandemic on perinatal outcomes in an Australian population with a high migrant rate and low prevalence of COVID-19. The results showed an increase in cesarean section births and a reduction in spontaneous preterm births and small for gestational age infants during the COVID-19 period. Full breastfeeding rates at hospital discharge also decreased. However, there was no change in induction of labor rates.
Article
Urology & Nephrology
Sibel G. Bek, Simone Marschner, Kamal Sud, David W. Johnson, Clara K. Chow, Carmel Hawley, Helen Pilmore, Germaine Wong, Wai Lim, Vincent W. Lee
Summary: This study found that smoking is associated with increased rates of all-cause mortality, cardiovascular mortality, respiratory failure, chronic lung disease, and malignancy in dialysis patients. It also increases the risk of non-skin cancers, de novo vascular disease, and chronic lung disease.
Review
Urology & Nephrology
Daniel V. O'Hara, Tae Won Yi, Vincent W. Lee, Meg Jardine, Jessica Dawson
Summary: Non-adherence to medications is a critical challenge in the management of people with chronic kidney disease. This review examines the role of emerging digital health technologies in addressing adherence issues and provides practical strategies for clinicians to support medication adherence.
Review
Urology & Nephrology
Chau Wei Ling, Kamal Sud, Vincent W. Lee, Gregory M. Peterson, Connie Van, Syed Tabish Razi Zaidi, Rahul P. Patel, Ronald L. Castelino
Summary: This study reviewed the literature and reported cases of PD-associated peritonitis caused by Rothia spp. in Australia and New Zealand. It found that PD-associated peritonitis due to Rothia spp. is uncommon and antibiotic treatment for 3 weeks is associated with better outcomes.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Article
Urology & Nephrology
James Tang, Martin Howell, Vincent W. Lee, Chandana Guha, Amanda Dominello, Simon Roger, Karen Keung, Armando Teixeira-Pinto, Allison Tong, Germaine Wong
Summary: This study investigated the use and perspectives of eHealth among kidney transplant recipients in Australia, and found that eHealth interventions have the potential to improve posttransplant care. The use of eHealth was associated with eHealth literacy level and education.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Gastroenterology & Hepatology
Qi Cao, Ruifeng Wang, Zhiguo Niu, Titi Chen, Farhana Azmi, Scott A. Read, Jianwei Chen, Vincent W. S. Lee, Chunze Zhou, Sohel Julovi, Qingsong Huang, Yuan Min Wang, Malcolm R. Starkey, Guoping Zheng, Stephen I. Alexander, Jacob George, Yiping Wang, David C. H. Harris
Summary: The study demonstrates the importance of type 2 innate lymphoid cells (ILC2s) as regulators in a mouse model of liver ischaemia/reperfusion injury (IRI). Manipulation of macrophage and eosinophil phenotypes by ILC2s mitigates liver inflammation and injury during liver IRI. ILC2s have the potential to serve as a therapeutic tool for protecting against acute liver injury and can be translated to human liver disease.
Meeting Abstract
Urology & Nephrology
Chau Wei Ling, Kamal Sud, Vincent W. Lee, Connie Van, Gregory M. Peterson, Syed Tabish Razi Zaidi, Rahul P. Patel, Ronald L. Castelino
Meeting Abstract
Urology & Nephrology
Emily Qian, Kamal Sud, Vincent Lee
Meeting Abstract
Urology & Nephrology
Priyanka Sagar, Alexandra Munt, Sayanthooran Saravanabavan, James Elhindi, Beatrice Nguyen, Katrina Chau, David Harris, Vincent Lee, Kamal Sud, Nikki Wong, Gopala Rangan
Meeting Abstract
Urology & Nephrology
Sayanthooran Saravanabavan, Alexandra Munt, Sunil Badve, Neil Boudville, Helen Coolican, Susan Coulshed, Sheryl Foster, Mangalee Fernando, Imad Haloob, David Harris, Carmel Hawley, Jane Holt, Martin Howell, Karthik Kumar, David Johnson, Vincent Lee, Maureen Lonergan, Jun Mai, Simon Roger, Kamal Sud, Allison Tong, Vicente Torres, Eswari Vilayur, Gopala Rangan
Meeting Abstract
Urology & Nephrology
Thiveya Theivendran, Kamal Sud, Karen Byth, Vincent W. Lee