Article
Infectious Diseases
Ian Boostrom, Yohan Bala, Jelena Minic Vasic, Jelena Gluvakov, Emmanuel Chanard, Andrew H. Barratt, Kirsty Sands, Edward Portal, Laurence Devigne, Lucy C. Jones, Owen B. Spiller
Summary: The study evaluated the accuracy, sensitivity and specificity of MYCOPLASMA IST3, showing promising results in detecting urogenital mycoplasma infections.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Immunology
Erica L. Plummer, Lenka A. Vodstrcil, Kaveesha Bodiyabadu, Gerald L. Murray, Michelle Doyle, Rosie L. Latimer, Christopher K. Fairley, Matthew Payne, Eric P. F. Chow, Suzanne M. Garland, Catriona S. Bradshaw
Summary: The study found that only Mycoplasma hominis was associated with symptoms/signs in nonpregnant women, specifically related to bacterial vaginosis. Ureaplasma species were not associated with symptoms/signs. Therefore, routine testing for Mycoplasma hominis, Ureaplasma urealyticum, and Ureaplasma parvum in nonpregnant women is not supported.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Can Wang, Jingshuang Wang, Juan Yan, Feng Chen, Ying Zhang, Xuelian Hu
Summary: This article reports four cases of peritoneal dialysis (PD)-associated peritonitis caused by Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum, along with a literature review. The four cases were female patients with recurrent culture-negative PD-associated peritonitis, which was related to menstruation. These pathogens were detected in the PD fluid of the patients using metagenomic next-generation sequencing. All four patients were cured by intraperitoneal tigecycline combined with oral azithromycin or minocycline. Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum should be given more attention in female patients with recurrent culture-negative PD-associated peritonitis, especially when it is related to menstruation, sexual intercourse, or urogenital tract operation. Moreover, metagenomic next-generation sequencing can provide a reasonable method to identify the pathogen for culture-negative PD-associated peritonitis.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Infectious Diseases
Mohammad H. Ahmadi
Summary: The global status of resistance to tetracyclines in Mycoplasma hominis and Ureaplasma species is relatively high and prevalent, with high levels of heterogeneity observed in all studies except for doxycycline resistance in M. hominis isolates. This highlights the importance of regional and local antibiotic susceptibility testing before treatment choice, as well as the development of newer generations of tetracyclines to prevent antibiotic misuse, emergence and spread of resistant strains, and treatment failure.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Obstetrics & Gynecology
Yasuhiro Miyoshi, Sachie Suga, So Sugimi, Nao Kurata, Hiroshi Yamashita, Ichiro Yasuhi
Summary: Vaginal colonization of Ureaplasma urealyticum/Mycoplasma hominis may predict preterm delivery in patients with threatened preterm birth or asymptomatic short cervix.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Infectious Diseases
Su Zhang, Ke Xu, Su-Xiao Liu, Xiao-Lan Ye, Ping Huang, Hong-Juan Jiang
Summary: This study investigated the prevalence of azithromycin-resistant U. urealyticum and M. hominis infections in pregnant women and explored the possible influencing factors and consequences of insensitive Mycoplasma infection. It was found that azithromycin-resistant cervical Mycoplasma infection in pregnant women was associated with a significantly increased incidence of adverse pregnancy outcomes.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Biology
Wei-wei Zheng, Wen-jing Zhang, Di Cui, Zheng-chao Nie, Bang-sheng Ding, Jiang-hua Cheng, Chuan-zhong Mei
Summary: The study revealed a high infection rate of Ureaplasma urealyticum and Mycoplasma hominis in the genitourinary tract of Chinese patients, primarily affecting individuals aged 21-40 years, with variations in antibiotic sensitivity.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Jingjing Luo, Xinan Wu, Xue Gang, Nana Zhang, Feifei Wang, Chengting Rong
Summary: This article reports a rare case of artificial joint infection caused by Mycoplasma hominis and Ureaplasma urealyticum. The patient recovered well after appropriate treatment, with no evidence of infection recurrence during the follow-up period.
Article
Medical Laboratory Technology
Lu-Qing Zheng, Qing-Yong Wang
Summary: We retrospectively reviewed reports of 4,166 female outpatients detected by the mycoplasma identification verification and antibiotic susceptibility kit from the last five years. Among them, more than 73.3% of cases with Ureaplasma urealyticum or Mycoplasma hominis single infection or co-infection with both species were susceptible to three tetracyclines and one macrolide (josamycin). Additionally, more than 84.8%, less than 4.4%, and less than 39.6% of the U. urealyticum, M. hominis, and co-infection cases, respectively, were susceptible to clarithromycin and roxithromycin. Four quinolones (ciprofloxacin, ofloxacin, sparfloxacin, and levofloxacin) and three macrolides (azithromycin, erythromycin, and acetylspiramycin) were active against less than 48.9% of the isolates. Furthermore, 77.8%, 18.4%, and 7.5% of the M. hominis, U. urealyticum, and co-infection cases, respectively, were susceptible to spectinomycin.
CLINICAL LABORATORY
(2023)
Article
Immunology
Amin Dehghan, Mohammad Reza Pourmand, Vahid Salimi, Firouzeh Akbari Asbagh, Abbas Rahimi Foroushani, Kaveh Sadeghi, Samaneh Hosseini Quchani
Summary: This study investigated the impact of CT, MH, and UU infections on semen quality and found that these infections significantly affect the quality and properties of male reproductive health.
MICROBIAL PATHOGENESIS
(2022)
Article
Infectious Diseases
Oliver Spiller-Boulter, Susanne Paukner, Ian Boostrom, Kirsty Sands, Edward A. R. Portal, Owen B. Spiller
Summary: Lefamulin, the first pleuromutilin antimicrobial available for human use, shows promising in vitro activity against Ureaplasma spp. and Mycoplasma hominis infections, regardless of intrinsic or acquired resistance to macrolides, lincosamides, and ketolides. Further exploration of its clinical efficacy in treating urogenital infections caused by these pathogens is warranted.
Article
Medicine, General & Internal
Bogdan Doroftei, Ovidiu-Dumitru Ilie, Theodora Armeanu, Emil Anton, Ioana Scripcariu, Radu Maftei
Summary: The prevalence of Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) among infertile women was 31.87%, with the most affected age group being women between thirty and thirty-five years old. The most efficient antibiotics in eradicating UU and MH were Pristinamycin and Josamycin, with other effective options including Doxycycline, Minocycline, Tetracycline, and Erythromycin.
MEDICINA-LITHUANIA
(2021)
Article
Microbiology
Jingjuan Song, Xuanlan Wu, Yingying Kong, Hong Jin, Ting Yang, Xinyou Xie, Jun Zhang
Summary: This study investigated the prevalence and antibiotic resistance profiles of Ureaplasma spp. and M. hominis in outpatients in Hangzhou, China, from 2013 to 2019. It found a high prevalence of Ureaplasma spp. compared to M. hominis and Ureaplasma spp./M. hominis, with distribution associated with sex and age. Josamycin, doxycycline, and tetracycline showed remarkable activity against these bacteria.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medical Laboratory Technology
Ruixiang Luo, Kang Xun, Lingli Zuo, Feifei Sha, Yun Chen, Nong Yu, Donghua Jin, Yuxian Xie, Meiling He, Fang Liu
Summary: This study investigated the infection and antimicrobial resistance of Ureaplasma urealyticum and Mycoplasma hominis in patients with genital tract diseases in Jiangsu, China. The results showed a high prevalence of U. urealyticum mono-infections and an increasing overall infection rate in the past 3 years. Females had a higher infection rate than males, and the main age group affected was 20-39. The antimicrobial resistance rates varied for different drugs, with lower resistance observed for gatifloxacin, josamycin, minocycline, and doxycycline, and higher resistance observed for azithromycin, clindamycin, roxithromycin, sparfloxacin, and ofloxacin. The antimicrobial resistance of U. urealyticum and M. hominis to these drugs has been changing in the past 3 years.
CLINICAL LABORATORY
(2022)
Article
Medical Laboratory Technology
Ruixiang Luo, Kang Xun, Lingli Zuo, Feifei Sha, Yun Chen, Nong Yu, Donghua Jin, Yuxian Xie, Meiling He, Fang Liu
Summary: This study aimed to investigate the infection and antimicrobial resistance of Ureaplasma urealyticum and Mycoplasma hominis in patients with genital tract diseases in Jiangsu, China. The results showed an increasing infection rate over the past 3 years, with higher rates in females and the 20-39 age group. U. urealyticum and M. hominis displayed relatively lower resistance rates to certain antibiotics, but higher resistance rates to others.
CLINICAL LABORATORY
(2021)
Article
Obstetrics & Gynecology
Hee-Sun Kim, Kyu-Min Lee, Sung Won Han, Geum Joon Cho, Han-Sung Hwang
Summary: This study found an association between pre-pregnancy body mass index and sensorineural hearing loss during pregnancy. However, SSNHL during pregnancy did not increase the risk during delivery or cause adverse perinatal outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Anesthesiology
Hee Jung Kim, Seung Ho Choi, Hayan Kwon, Eun Kyung Park, Ja-Young Kwon, Hyukjin Yang, Seung Hyun Kim
Summary: Compared with general anesthesia, spinal anesthesia mitigated the maximum arterial blood pressure during cesarean delivery and improved postoperative pain in patients with moyamoya disease.
ANESTHESIA AND ANALGESIA
(2022)
Editorial Material
Gastroenterology & Hepatology
Ja-Young Kwon
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Obstetrics & Gynecology
Yeonseong Jeong, Yun Ji Jung, Eunjin Noh, Sungyeon Ha, Jeongeun Hwang, Geum Joon Cho, Min-Jeong Oh, Young-Han Kim
Summary: This population-based study shows that the occurrence rate of cerebrovascular disease (CVD) after delivery is higher in women with Moyamoya disease. Therefore, careful and long-term postpartum surveillance is required for these women.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Multidisciplinary Sciences
Min-A Kim, Eun-Ju Lee, Wookyeom Yang, Ha-Yeon Shin, Young-Han Kim, Jae-Hoon Kim
Summary: This study found differential gene expression between preterm birth and term birth, which is associated with oxidative stress and infection during pregnancy. The study also identified potential markers for the early identification of women at risk of having a spontaneous preterm birth.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Jeong Ha Wie, Se Jin Lee, Sae Kyung Choi, Yun Sung Jo, Han Sung Hwang, Mi Hye Park, Yeon Hee Kim, Jae Eun Shin, Ki Cheol Kil, Su Mi Kim, Bong Suk Choi, Hanul Hong, Hyun-Joo Seol, Hye-Sung Won, Hyun Sun Ko, Sunghun Na
Summary: This study developed an automated machine learning model to predict emergent cesarean section before onset of labor in term nulliparous women. Nine different machine learning methods were applied and compared, with logistic regression showing the best predictive performance. The model identified several significant variables for prediction of emergent cesarean section.
Article
Multidisciplinary Sciences
Sunwha Park, Young-Ah You, Young-Han Kim, Eunjin Kwon, AbuZar Ansari, Soo Min Kim, Gain Lee, Young Min Hur, Yun Ji Jung, Kwangmin Kim, Young Ju Kim
Summary: Ureaplasma and Prevotella colonization is associated with preterm birth, but not all colonizations cause it. This study found a positive correlation between Ureaplasma and other genera with preterm birth, and a negative correlation between Lactobacillus and term birth, similar to Prevotella. Balanced colonization between Lactobacillus and Ureaplasma and Prevotella is important to prevent preterm birth.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Sunwha Park, Jeongsup Moon, Nayeon Kang, Young-Han Kim, Young-Ah You, Eunjin Kwon, AbuZar Ansari, Young Min Hur, Taesung Park, Young Ju Kim
Summary: An association between the vaginal microbiome and preterm birth has been reported, but predicting premature birth using the microbiome is difficult due to high variability among individuals. This study used machine learning to select markers and develop a prediction algorithm that combines clinical information, improving the predictive power for preterm birth.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Eun-Jeong Jang, Young-Ju Kim, Han-Sung Hwang, Jeong Yee, Hye-Sun Gwak
Summary: This study found significant associations between single nucleotide polymorphisms in GNAS and RGS2 genes and ritodrine-induced adverse events. A risk scoring system was developed to identify high-risk patients.
Article
Medicine, General & Internal
Minjeong Nam, Mina Hur, Hanah Kim, Gun-Hyuk Lee, Mikyoung Park, Han-Sung Kwon, Han-Sung Hwang, In-Sook Sohn
Summary: This study established reference intervals for presepsin, KL-6, and SP-A levels and evaluated the influence of neonatal and maternal factors on these levels in umbilical cord blood. The levels showed non-parametric distributions and no significant differences were found based on the analyzed factors. The study also found a slight increase in KL-6 levels with gestational age.
Article
Immunology
Yun Ji Jung, Yeji Lee, Hayan Kwon, Hyoung-Pyo Kim, Han-Sung Kwon, Eunhyang Park, JoonHo Lee, Young-Han Kim, Yong-Sun Maeng, Ja-Young Kwon
Summary: In pre-eclampsia, decidual lymphatic endothelial cells (dLECs) induce the polarization of decidual macrophages into the proinflammatory M1 phenotype through the secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) via the NF-κB-dependent pathway.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
Hyungwoo Lee, Seung-Woo Yang, Yeji Kim, Hyunju Shin, Yong-Soo Seo, Min Jeong Oh, Sangbum Choi, Geum Joon Cho, Han-Sung Hwang
Summary: In this large cohort study, a history of pregnancy-induced hypertension was found to increase the risk of central serous chorioretinopathy, diabetic retinopathy, retinal vein occlusion, and hypertensive retinopathy in the long-term postpartum stage. These findings highlight the importance of understanding the relationship between pregnancy-induced hypertension and ocular diseases.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Medicine, General & Internal
Ji Hea Yu, Yun Ji Jung, Myung-Sun Kim, Sung-Rae Cho, Young-Han Kim
Summary: This study investigated the expression changes of NME4 in preeclampsia (PE) using trophoblast stem-like cells (TSLCs) from induced pluripotent stem cells (iPSCs) as a model of early pregnancy and peripheral blood mononuclear cells (PBMNCs) as a model of late preterm pregnancy. The results showed that NME4 was significantly downregulated in TSLCs but upregulated in PBMNCs of PE. This expression pattern may serve as a potential biomarker for early diagnosis of PE.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Peripheral Vascular Disease
Hyeon Chang Kim, Hokyou Lee, Hyeok-Hee Lee, Eunsun Seo, Eunji Kim, Jiyen Han, Ja-Young Kwon
Summary: The Korea Hypertension Fact Sheet 2021 provides an overview of hypertension magnitude and management in Korea. The report highlights the need for improved awareness and treatment in young adults and the increasing cases of hypertensive disorders during pregnancy.
CLINICAL HYPERTENSION
(2022)
